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公开(公告)号：EP1015039B1
公开(公告)日：2008-08-27
申请号：EP98928973.1
申请日：1998-06-10
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , McGREERY, Thomas , WU, Yunqiu
CPC classification number: A61K49/223 , A61K9/1271 , A61K41/0028 , A61K47/544
Abstract: The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery agents or blood substitutes.
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公开(公告)号：EP0831932B1
公开(公告)日：2004-05-06
申请号：EP96921486.5
申请日：1996-06-06
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , SHEN, Dekang , WU, Guanli
CPC classification number: B82Y5/00 , A61K49/0002 , A61K49/223 , A61K49/227 , A61K49/228
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33.发明授权IMPROVED METHODS FOR DIAGNOSTIC IMAGING USING A CONTRAST AGENT AND A VASODILATOR 失效用于诊断成像改进的过程中使用造影剂和血管扩张剂
公开(公告)号：EP0977597B1
公开(公告)日：2003-01-15
申请号：EP97940615.4
申请日：1997-08-26
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C.
CPC classification number: A61B5/411 , A61B5/201 , A61K49/223 , A61K49/227
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公开(公告)号：EP1037673A1
公开(公告)日：2000-09-27
申请号：EP98906695.6
申请日：1998-02-25
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C.
CPC classification number: A61K49/223 , A61K9/1271 , A61K41/0028 , A61K47/544 , Y10T428/2984
Abstract: The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.
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公开(公告)号：EP1015039A1
公开(公告)日：2000-07-05
申请号：EP98928973.1
申请日：1998-06-10
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , McGREERY, Thomas , WU, Yunqiu
CPC classification number: A61K49/223 , A61K9/1271 , A61K41/0028 , A61K47/544
Abstract: The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery agents or blood substitutes.
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Patent Agency Ranking
公开(公告)号：EP0981333A1
公开(公告)日：2000-03-01
申请号：EP98926033.6
申请日：1998-05-12
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C.
CPC classification number: A61K9/5123 , A61K9/0009 , A61K9/1075 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/145 , A61K9/146 , A61K41/0028 , A61K47/62 , A61K47/6925 , A61K49/223 , B82Y5/00
Abstract: The present invention is directed to targeted therapeutic delivery systems comprising a gas or gaseous precursor filled microsphere wherein said gas or gaseous precursor filled microsphere comprises an oil, a surfactant, and a therapeutic compound. Methods of preparing the targeted therapeutic delivery systems are also embodied by the present invention which comprise processing a solution comprising an oil and a surfactant in the presence of a gaseous precursor, at a temperature below the gel to liquid crystalline phase transition temperature of the surfactant to form gas or gaseous precursor filled microsphere, and adding to said microspheres a therapeutic compound resulting in a targeted therapeutic delivery system, wherein said processing is selected from the group consisting of controlled agitation, controlled drying, and a combination thereof.
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公开(公告)号：EP0923383A1
公开(公告)日：1999-06-23
申请号：EP97920281.0
申请日：1997-04-02
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , FRITZ, Thomas , MATSUNAGA, Terry , RAMASWAMI, VaradaRajan , YELLOWHAIR, David , WU, Guanli
CPC classification number: A61K9/1277 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K49/22 , A61K49/223 , A61K49/227 , A61M5/3145 , G01R33/5601
Abstract: Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
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38.发明授权IMPROVED METHODS FOR DIAGNOSTIC IMAGING INVOLVING THE USE OF A CONTRAST AGENT AND A CORONARY VASODILATOR 失效用于诊断成像方法的改进使用造影剂和冠状动脉扩张剂
公开(公告)号：EP1017425B1
公开(公告)日：2007-10-17
申请号：EP97938609.1
申请日：1997-08-26
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C.
IPC: A61K49/22
CPC classification number: A61B5/411 , A61B5/201 , A61K49/223 , A61K49/227
Abstract: Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.
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公开(公告)号：EP1039834B1
公开(公告)日：2005-09-28
申请号：EP98964127.9
申请日：1998-12-17
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , WU, Yunqiu
CPC classification number: A61K49/0002
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公开(公告)号：EP0983060A1
公开(公告)日：2000-03-08
申请号：EP98921109.9
申请日：1998-05-12
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C.
IPC: A61K9/10
CPC classification number: A61K9/0009 , A61K9/1272 , A61K9/145 , A61K9/146 , A61K9/5115 , A61K9/5146 , A61K9/5192 , A61K41/0028 , A61K47/6925 , B82Y5/00
Abstract: A solid porous matrix formed from a surfactant, a solvent, and a bioactive agent.
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