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公开(公告)号：WO1997040858A1
公开(公告)日：1997-11-06
申请号：PCT/US1997005908
申请日：1997-04-02
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： IMARX PHARMACEUTICAL CORP. , UNGER, Evan, C. , FRITZ, Thomas , MATSUNAGA, Terry , RAMASWAMI, VaradaRajan , YELLOWHAIR, David , WU, Guanli
IPC: A61K49/04
CPC classification number: A61K9/1277 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K49/22 , A61K49/223 , A61K49/227 , A61M5/3145 , G01R33/5601
Abstract: Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
Abstract translation: 冻干脂质组合物及其制备方法由本发明体现。 使用冻干的脂质组合物制备的充气微球在例如超声成像应用和治疗药物递送系统中是特别有用的。
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2.发明申请CONTAINER WITH MULTI-PHASE COMPOSITION FOR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开具有多相组合的容器用于诊断和治疗应用
公开(公告)号：WO1996008234A1
公开(公告)日：1996-03-21
申请号：PCT/US1995009392
申请日：1995-07-26
Applicant: IMARx PHARMACEUTICAL CORP.
IPC: A61K09/127
CPC classification number: A61K49/227 , A61K8/046 , A61K8/14 , A61K8/70 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/51 , A61K47/6925 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K2800/87 , A61M5/3145 , A61Q19/00 , G01R33/5601 , Y10T428/2984
Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
Abstract translation: 公开了一种容器，其包含水性脂质悬浮液和基本上与水稳定相分离的气相，其用于诸如超声和磁共振成像以及治疗应用的诊断成像。
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公开(公告)号：EP0923383A1
公开(公告)日：1999-06-23
申请号：EP97920281.0
申请日：1997-04-02
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , FRITZ, Thomas , MATSUNAGA, Terry , RAMASWAMI, VaradaRajan , YELLOWHAIR, David , WU, Guanli
CPC classification number: A61K9/1277 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K49/22 , A61K49/223 , A61K49/227 , A61M5/3145 , G01R33/5601
Abstract: Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
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Patent Agency Ranking4.发明授权
公开(公告)号：EP0788348B1
公开(公告)日：2004-07-14
申请号：EP95927429.1
申请日：1995-07-26
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , MATSUNAGA, Terry, O. , YELLOWHAIR, David
CPC classification number: A61K49/227 , A61K8/046 , A61K8/14 , A61K8/70 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/51 , A61K47/6925 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K2800/87 , A61M5/3145 , A61Q19/00 , G01R33/5601 , Y10T428/2984
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5.发明公开
公开(公告)号：EP0840570A2
公开(公告)日：1998-05-13
申请号：EP96938613.0
申请日：1996-06-06
Applicant: IMARx PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , McCREERY, Thomas , YELLOWHAIR, David , BARRETTE, Terrence, R.
IPC: A61K49 , A61B5 , A61B8 , A61K8 , A61K9 , A61K41 , A61K47 , A61Q19 , B01F3 , B01F11 , A61J3 , A61M5 , B01F15
CPC classification number: A61K49/22 , A61J3/00 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K2800/87 , A61M5/3145 , B01F3/04099 , B01F11/0025 , B01F13/0033 , B01F15/00435 , Y10S366/605
Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3°. The total length of travel around the figure-8 pattern is at least 0.7 cm.
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6.发明公开
公开(公告)号：EP0788348A1
公开(公告)日：1997-08-13
申请号：EP95927429.0
申请日：1995-07-26
Applicant: IMARX PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , MATSUNAGA, Terry, O. , YELLOWHAIR, David
CPC classification number: A61K49/227 , A61K8/046 , A61K8/14 , A61K8/70 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/51 , A61K47/6925 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K2800/87 , A61M5/3145 , A61Q19/00 , G01R33/5601 , Y10T428/2984
Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
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7.发明授权
公开(公告)号：EP0840570B1
公开(公告)日：2003-08-13
申请号：EP96938613.5
申请日：1996-06-06
Applicant: IMARx PHARMACEUTICAL CORP.
Inventor： UNGER, Evan, C. , McCREERY, Thomas , YELLOWHAIR, David , BARRETTE, Terrence, R.
CPC classification number: A61K49/22 , A61J3/00 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K2800/87 , A61M5/3145 , B01F3/04099 , B01F11/0025 , B01F13/0033 , B01F15/00435 , Y10S366/605
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公开(公告)号：EP0740528A1
公开(公告)日：1996-11-06
申请号：EP95908414.0
申请日：1994-11-30
Applicant: Imarx Pharmaceutical Corp.
Inventor： UNGER, Evan C. , MATSUNAGA, Terry , YELLOWHAIR, David
CPC classification number: A61K9/1271 , A61K8/14 , A61K8/70 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/6925 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61K2800/87 , A61M5/3145 , A61Q19/00 , Y10S436/829
Abstract: Gas and gaseous precursor filled microspheres (1), and foams thereof, provide novel topical and subcutaneous delivery vehicles for various active ingredients, including drugs and cosmetics (2).
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