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31.发明授权公开(公告)号：US10646519B2
公开(公告)日：2020-05-12
申请号：US15949808
申请日：2018-04-10
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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32.发明申请公开(公告)号：US20180360886A1
公开(公告)日：2018-12-20
申请号：US15949808
申请日：2018-04-10
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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33.发明申请公开(公告)号：US20180104282A1
公开(公告)日：2018-04-19
申请号：US15632142
申请日：2017-06-23
Applicant: Osiris Therapeutics, Inc.
Inventor： Steven Michael Sinclair , Alla Danilkovitch , Malathi Sathyamoorthy , Jin-Qiang Kuang , Sandeep Dhall , Anthony John Melchiorri
CPC classification number: A61K35/50 , A01N1/0221 , A01N1/0284 , A61F13/00 , A61K9/1682 , A61K9/19 , A61K35/32 , A61K35/36 , A61L27/3604 , A61L27/3608 , A61L27/362 , A61L27/3691
Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.
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公开(公告)号：US12268797B2
公开(公告)日：2025-04-08
申请号：US17681064
申请日：2022-02-25
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
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35.发明公开公开(公告)号：US20240050482A1
公开(公告)日：2024-02-15
申请号：US18101727
申请日：2023-01-26
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2502/025 , C12N2501/115
Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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Patent Agency Ranking
公开(公告)号：US11590172B2
公开(公告)日：2023-02-28
申请号：US16296463
申请日：2019-03-08
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana YOo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US11406735B2
公开(公告)日：2022-08-09
申请号：US14485210
申请日：2014-09-12
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
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公开(公告)号：US10828395B2
公开(公告)日：2020-11-10
申请号：US15298142
申请日：2016-10-19
Applicant: Osiris Therapeutics, Inc.
Inventor： Thomas E. Uveges , Jin-Qiang Kuang , Alla Danilkovitch , S. Michael Sinclair , Sandra D. Geraghty
Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.
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公开(公告)号：US20200069739A1
公开(公告)日：2020-03-05
申请号：US16296475
申请日：2019-03-08
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US10576104B2
公开(公告)日：2020-03-03
申请号：US14070035
申请日：2013-11-01
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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