公开(公告)号：ES2597436T3

公开(公告)日：2017-01-18

申请号：ES08834136

申请日：2008-09-26

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61K38/48 ,  A61K39/00 ,  A61P7/04 ,  C12N9/64

Abstract: Un derivado de fXa que es un polipéptido aislado que comprende la secuencia de aminoácidos de la SEQ ID NO. 12.

公开(公告)号：AU2014210620B2

公开(公告)日：2016-05-12

申请号：AU2014210620

申请日：2014-08-07

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61P7/02 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/715 ,  A61K31/727 ,  A61K38/36 ,  A61K38/48 ,  A61K39/00 ,  A61K39/395 ,  A61K47/48 ,  A61P7/04 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N5/10 ,  C12N9/64 ,  C12P21/00

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

公开(公告)号：HK1210443A1

公开(公告)日：2016-04-22

申请号：HK15111214

申请日：2015-11-13

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61P20060101 ,  A61K20060101 ,  A61K39/00

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa.The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

公开(公告)号：AU2009314153B2

公开(公告)日：2015-09-17

申请号：AU2009314153

申请日：2009-11-11

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA

IPC: A61K35/14 ,  A61K35/16 ,  A61K38/16 ,  A61K38/48 ,  A61P7/04

Abstract: The present invention relates to antidotes of anticoagulants targeting factor Xa which antidotes are used in combination with blood coagulating agents or other heparin antidotes to prevent or reduce bleeding in a subject. The antidotes described herein have reduced or no intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is or will be undergoing anticoagulant therapy with a factor Xa inhibitor.

公开(公告)号：AU2013375294A1

公开(公告)日：2015-08-27

申请号：AU2013375294

申请日：2013-03-13

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA ,  KARBARZ MARK ,  PANDEY ANJALI ,  CONLEY PAMELA B

IPC: C07K14/745 ,  A61K38/48 ,  A61K47/48 ,  C12N9/64

Abstract: The present disclosure relates to compositions and methods for the treatment of bleeding disorders, such as hemophilia A, hemophilia B, von Willebrand (vWF) disease, and factor XII deficiency, by reducing the circulating concentration of tissue factor pathway inhibitor (TFPI), with a factor Xa derivative.

公开(公告)号：CA2898975A1

公开(公告)日：2014-07-31

申请号：CA2898975

申请日：2013-03-13

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA ,  KARBARZ MARK ,  PANDEY ANJALI ,  CONLEY PAMELA B

IPC: A61K38/48 ,  A61K47/48 ,  C07K14/745 ,  C12N9/64

Abstract: The present disclosure relates to compositions and methods for the treatment of bleeding disorders, such as hemophilia A, hemophilia B, von Willebrand (vWF) disease, and factor XII deficiency, by reducing the circulating concentration of tissue factor pathway inhibitor (TFPI), with a factor Xa derivative.

公开(公告)号：AU2008304192B2

公开(公告)日：2014-05-15

申请号：AU2008304192

申请日：2008-09-26

Applicant: PORTOLA PHARM INC

Inventor： SINHA UMA ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  LU GENMIN

IPC: A61P7/02 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/715 ,  A61K31/727 ,  A61K38/36 ,  A61K38/48 ,  A61K39/00 ,  A61K39/395 ,  A61K47/48 ,  A61P7/04 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N5/10 ,  C12N9/64 ,  C12P21/00

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

公开(公告)号：NZ592837A

公开(公告)日：2012-10-26

申请号：NZ59283709

申请日：2009-11-11

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA

IPC: A61K38/48 ,  A61K35/14 ,  A61K35/16 ,  A61K38/16 ,  A61P7/04

Abstract: Provided is a pharmaceutical composition comprising (i) an isolated polypeptide comprising a specified amino acid sequence that has reduced procoagulant activity compared to wild-type factor Xa, (c) is capable of binding to a factor Xa inhibitor and (d) does not assemble into a prothrombinase complex, and (ii) a blood coagulating agent. The synergistic combination can be used to treat or prevent bleeding in a patient having anticoagulant therapy with fXa inhibitor.

公开(公告)号：SI3078743T1

公开(公告)日：2020-08-31

申请号：SI200832130

申请日：2008-09-26

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: C12N9/00 ,  A61K38/00 ,  A61K39/00 ,  A61P7/00

公开(公告)号：ZA201408921B

公开(公告)日：2020-08-26

申请号：ZA201408921

申请日：2014-12-04

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA

Abstract: Disclosed herein are methods and kits for purifying a serine protease. The methods entail loading the serine protease to a soybean trypsin inhibitor (STI) based affinity chromatograph, and eluting the serine protease with an elution buffer comprising an agent that disrupts interaction between the STI and the serine protease.