公开(公告)号：EA004591B1

公开(公告)日：2004-06-24

申请号：EA200200299

申请日：2002-03-27

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSLEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE

IPC: C07D295/18 ,  A61K31/40 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/5377 ,  A61K38/00 ,  A61P1/00 ,  A61P1/02 ,  A61P3/04 ,  A61P3/10 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07B57/00 ,  C07D207/16 ,  C07D231/04 ,  C07D233/06 ,  C07D233/48 ,  C07D277/04 ,  C07D277/06 ,  C07D277/10 ,  C07D295/22 ,  C07D403/12 ,  C07K5/062 ,  C07K5/078 ,  C07K5/087 ,  C07K5/097 ,  C07D295/185 ,  C07D295/26

Abstract: Соединениеформулы (I):вкоторойпредставляетсобой 5-членный, азотсодержащийгетероцикл,Rпредставляетсобойатомводородаилиалкильную, ацильную, пролильную, аланильную, гистидилпролильнуюилифенилаланилпролильнуюгруппу,Ak представляетсобойалкиленовуюцепьилигетероалкиленовуюцепь,Хпредставляетсобойодинарнуюсвязьилинеобязательнозамещеннуюфениленовуюгруппу,Rпредставляетсобойнеобязательнозамещеннуюалкильнуюгруппу (С-С)циклоалкильнуюгруппу, или -NRR, вкоторой Rи R, которыемогутбытьодинаковымиилиразличными, каждаяпредставляетсобойатомводорода, илилинейнуюилиразветвленную (С-С)алкильнуюгруппу, илисовместнос атомомазота, несущимих, образуютазотсодержащийгетероцикл,Y представляетсобойгруппу -NR-,Rпредставляетсобойатомводородаилигруппу, выбираемуюизалкила, (С-С)циклоалкилаи арила,R, Rи R, которыемогутбытьодинаковымиилиразличными, каждаяпредставляетсобойатомводородаилиалкильнуюгруппу, или Rи R, или Rи R, совместнос атомами, ихнесущими, образуютимидазолидиновоеилидигидробензимидазольноекольцо,ихоптическиеизомерыи ихаддитивныесолис фармацевтическиприемлемойкислотой.Лекарственныепрепараты.

公开(公告)号：EA004254B1

公开(公告)日：2004-02-26

申请号：EA200101230

申请日：2001-12-21

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04 ,  A61K31/443 ,  A61K31/4355

Abstract: Соединенияформулы (I)вкоторой Rпредставляетсобойатомводорода, атомгалогена, алкильнуюгруппуилиалкоксигруппу, Хпредставляетсобойатомкислорода, атомсерыилигруппу NR, вкоторой R представляетсобойатомводородаилиалкильнуюгруппу, Апредставляетсобойлюбуюизгрупп, описанныхв описании, ихизомеры, иихаддитивныесолис фармацевтическиприемлемойкислотойилиоснованием. Лекарственныепрепараты.

公开(公告)号：AU770168B2

公开(公告)日：2004-02-12

申请号：AU4378400

申请日：2000-06-30

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  BENOIST ALAIN ,  BONNET JACQUELINE ,  SBATINI MASSIMO ,  ATASSI GHANEM ,  PIERRE ALAIN

IPC: C07D307/77 ,  A61K31/4355 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/5377 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048

Abstract: N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives (I), their isomers and acid and base addition salts, their preparation and compositions containing them. N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives of formula (I), their isomers and acid and base addition salts, their preparation and compositions containing them: R1 = H, halogen, 1-6C alkyl or alkoxy; R2 = OH, 1-6C alkoxy, or NHOH; Ar1 = phenylene or biphenylene; X = O, S, NR, -OC- or a bond; R = H, or 1-6C alkyl; n = 0-6; Ar2 = phenyl substituted by heteroaryl, biphenyl substituted by heteroaryl, pyridinyl substituted by heteroaryl, or a heterocycle

公开(公告)号：HK1050357A1

公开(公告)日：2003-06-20

申请号：HK03101863

申请日：2003-03-14

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE

IPC: C07D295/18 ,  A61K31/40 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/5377 ,  A61K38/00 ,  A61P1/00 ,  A61P1/02 ,  A61P3/04 ,  A61P3/10 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07B57/00 ,  C07D207/16 ,  C07D231/04 ,  C07D233/06 ,  C07D233/48 ,  C07D277/04 ,  C07D277/06 ,  C07D277/10 ,  C07D295/22 ,  C07D403/12 ,  C07K5/062 ,  C07K5/078 ,  C07K5/087 ,  C07K5/097 ,  C07D ,  A61P ,  A61K

Abstract: Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. ring A = a 5 membered nitrogen heterocycle that may be substituted by cyano; R1 = H, 1-6C alkyl or acyl, prolyl, alanyl, histidylprolyl, or phenylalanylprolyl; Ak = 1-6C alkylene or heteroalkylene; X = a bond or phenylene optionally substituted by one or more groups selected from halogens, 1-6C alkyl, alkoxy or polyhaloalkyl, or OH; R2 = 1-6C alkyl (optionally substituted by one or more groups selected from aryl, 1-6C alkylsulfonyl, 3-7C cycloalkylsulfonyl, 3-7C cycloalkyl, and halogen), 3-10C cycloalkyl, or a group -NR2aR2b; R2a and R2b = H, 1-6C alkyl, or together with the N atom they form a nitrogen heterocycle; Y = -NR3, -NH-CH=N-, -C(=NH)-NH-, or -NR4-C(=NR5)-NR6-; R3 = H, 1-6C alkyl, 3-7C cycloalkyl, or aryl; R4, R5, R6 = H, 1-6C alkyl; or R4 and R6 together, or R5 and R6 together = imidazolidine or dihydrobenzimidazole in which the term nitrogen heterocycle encompasses a monocyclic saturated ring of 5 - 7 members having 1 - 3 heteroatoms at least one of which is N and others may be N, O or S, and the term 1-6c alkylene encompasses a group that may be straight or branched and one methylene group may be replaced by an atom or O or S.

公开(公告)号：DE60002395D1

公开(公告)日：2003-06-05

申请号：DE60002395

申请日：2000-06-30

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  BONNET JACQUELINE ,  SABATINI MASSIMO ,  ATASSI GHANEM ,  PIERRE ALAIN

IPC: C07D307/77 ,  A61K31/4355 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/5377 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048

Abstract: N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives (I), their isomers and acid and base addition salts, their preparation and compositions containing them. N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives of formula (I), their isomers and acid and base addition salts, their preparation and compositions containing them: R1 = H, halogen, 1-6C alkyl or alkoxy; R2 = OH, 1-6C alkoxy, or NHOH; Ar1 = phenylene or biphenylene; X = O, S, NR, -OC- or a bond; R = H, or 1-6C alkyl; n = 0-6; Ar2 = phenyl substituted by heteroaryl, biphenyl substituted by heteroaryl, pyridinyl substituted by heteroaryl, or a heterocycle

公开(公告)号：FR2821842B1

公开(公告)日：2003-05-09

申请号：FR0103068

申请日：2001-03-07

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  LEFOULON FRANCOIS ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON ,  BRIDON DOMINIQUE ,  EZRIN ALAN ,  HOLMES DARREN ,  HUANG XICAI

IPC: A61P35/00 ,  C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  C07D471/14

公开(公告)号：HU0201646A2

公开(公告)日：2003-02-28

申请号：HU0201646

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： BENOIST ALAIN ,  BOULANGER MICHELLE ,  HUSSON-ROBERT BERNADETTE ,  LEVENS NIGEL ,  DE NANTEUIL GUILLAUME ,  NOSJEAN OLIVIER ,  PORTEVIN BERNARD

IPC: A61K31/40 ,  C07D295/10 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：ZA200202525B

公开(公告)日：2002-10-24

申请号：ZA200202525

申请日：2002-03-28

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE

IPC: C07D295/18 ,  A61K31/40 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/5377 ,  A61K38/00 ,  A61P1/00 ,  A61P1/02 ,  A61P3/04 ,  A61P3/10 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07B57/00 ,  C07D207/16 ,  C07D231/04 ,  C07D233/06 ,  C07D233/48 ,  C07D277/04 ,  C07D277/06 ,  C07D277/10 ,  C07D295/22 ,  C07D403/12 ,  C07K5/062 ,  C07K5/078 ,  C07K5/087 ,  C07K5/097 ,  C07D ,  A61K ,  A61P

Abstract: Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. Sulfonated amino acid derivatives (I), their optical isomers and acid addition salts, are new. ring A = a 5 membered nitrogen heterocycle that may be substituted by cyano; R1 = H, 1-6C alkyl or acyl, prolyl, alanyl, histidylprolyl, or phenylalanylprolyl; Ak = 1-6C alkylene or heteroalkylene; X = a bond or phenylene optionally substituted by one or more groups selected from halogens, 1-6C alkyl, alkoxy or polyhaloalkyl, or OH; R2 = 1-6C alkyl (optionally substituted by one or more groups selected from aryl, 1-6C alkylsulfonyl, 3-7C cycloalkylsulfonyl, 3-7C cycloalkyl, and halogen), 3-10C cycloalkyl, or a group -NR2aR2b; R2a and R2b = H, 1-6C alkyl, or together with the N atom they form a nitrogen heterocycle; Y = -NR3, -NH-CH=N-, -C(=NH)-NH-, or -NR4-C(=NR5)-NR6-; R3 = H, 1-6C alkyl, 3-7C cycloalkyl, or aryl; R4, R5, R6 = H, 1-6C alkyl; or R4 and R6 together, or R5 and R6 together = imidazolidine or dihydrobenzimidazole in which the term nitrogen heterocycle encompasses a monocyclic saturated ring of 5 - 7 members having 1 - 3 heteroatoms at least one of which is N and others may be N, O or S, and the term 1-6c alkylene encompasses a group that may be straight or branched and one methylene group may be replaced by an atom or O or S.

公开(公告)号：ZA200110517B

公开(公告)日：2002-07-11

申请号：ZA200110517

申请日：2001-12-21

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04 ,  C07D ,  A61K

Abstract: 5-Sulfonyl-2-(4-pyridinyl)-benzofuran, benzothiophene or indole derivatives (I), containing a hydroxamic acid function, are new. Benzofuran, benzothiophene or indole derivatives of formula (I) and their isomers, N-oxides and acid or base addition salts are new. R1 = H, halo, 1-6C alkyl or 1-6C alkoxy; X = O, S or NR; R = H or 1-6C alkyl; A = N-hydroxy-carboxamido-substituted tetrahydrofuropyridine, thiomorpholine or tetrahydropyranylmethyl group of formula (i)-(iii); Ra = H, halo, 1-6C alkyl or 1-6C alkoxy; Rb, Rc = H or 1-6C alkyl; and n = 0-2. An Independent claim is also included for the preparation of (I).

公开(公告)号：CY1106878T1

公开(公告)日：2012-09-26

申请号：CY071101205

申请日：2007-09-19

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  COMBETTES MURIELLE ,  HARLEY ELIZABETH

IPC: C07D295/18 ,  C07D405/12 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/426 ,  A61K31/427 ,  A61K31/438 ,  A61P3/10 ,  A61P43/00 ,  C07D207/06 ,  C07D207/10 ,  C07D207/16 ,  C07D277/06 ,  C07D277/12 ,  C07D295/185 ,  C07D311/96 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D417/12

Abstract: Ένωσητύπου (Ι):