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公开(公告)号:DE69921367D1
公开(公告)日:2004-11-25
申请号:DE69921367
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: TURNER HOWARD , DALES G CAMERON , VAN ERDEN LYNN , VAN BEEK JOHANNES A M , HAJDUK DAMIAN A , NIELSEN RALPH B , MANSKY PAUL , MATSIEV LEONID , WANG PEI , MCFARLAND ERIC
IPC: B01J19/18 , B01F13/06 , B01F13/08 , B01F15/00 , B01J19/00 , B01J19/26 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/25 , G01N35/10 , G05B23/02 , G05D21/00 , B01F7/16
Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号:CA2381014C
公开(公告)日:2003-07-08
申请号:CA2381014
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: MATSIEV LEONID , TURNER HOWARD , DALES G CAMERON , WANG PEI , VAN ERDEN LYNN , MANSKY PAUL , MCFARLAND ERIC , NIELSEN RALPH B , HAJDUK DAMIAN A , VAN BEEK JOHANNES A M
Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
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公开(公告)号:AT241427T
公开(公告)日:2003-06-15
申请号:AT99942147
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: TURNER HOWARD , DALES G CAMERON , VAN ERDEN LYNN , VAN BEEK JOHANNES A M , HAJDUK DAMIAN A , NIELSEN RALPH B , MANSKY PAUL , MATSIEV LEONID , WANG PEI , MCFARLAND ERIC
IPC: B01J19/18 , B01F13/06 , B01F13/08 , B01F15/00 , B01J19/00 , B01J19/26 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/25 , G01N35/10 , G05B23/02 , G05D21/00
Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号:DE69708331T2
公开(公告)日:2002-07-11
申请号:DE69708331
申请日:1997-07-22
Applicant: SYMYX TECHNOLOGIES INC
Inventor: WEINBERG HENRY W , MCFARLAND ERIC , GOLDWASSER ISY , BOUSSIE THOMAS , TURNER HOWARD , BEEK JOHANNES A M VAN , MURPHY VINCE , POWERS TIMOTHY
IPC: B01J23/22 , B01J19/00 , B01J31/16 , B01J31/22 , B01J37/00 , C07B61/00 , C07C249/02 , C07C251/08 , C07C251/16 , C07D213/53 , C07F15/00 , C07F15/04 , C07F17/00 , C07F19/00 , C08F4/00 , C08F4/60 , C08F4/70 , C08F10/00 , C08F110/02 , C40B40/04 , C40B40/18 , C40B50/00 , C40B60/14 , G01N1/10 , G01N21/64 , G01N29/24 , G01N29/34 , G01N29/44
Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.
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公开(公告)号:DE69708928T2
公开(公告)日:2002-06-20
申请号:DE69708928
申请日:1997-07-22
Applicant: SYMYX TECHNOLOGIES INC
Inventor: WEINBERG HENRY W , MCFARLAND ERIC , GOLDWASSER ISY , BOUSSIE THOMAS , TURNER HOWARD , BEEK JOHANNES A M VAN , MURPHY VINCE , POWERS TIMOTHY
IPC: B01J23/22 , B01J19/00 , B01J31/16 , B01J31/22 , B01J37/00 , C07B61/00 , C07C249/02 , C07C251/08 , C07C251/16 , C07D213/53 , C07F15/00 , C07F15/04 , C07F17/00 , C07F19/00 , C08F4/00 , C08F4/60 , C08F4/70 , C08F10/00 , C08F110/02 , C40B40/04 , C40B40/18 , C40B50/00 , C40B60/14 , G01N1/10 , G01N21/64 , G01N29/24 , G01N29/34 , G01N29/44
Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.
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公开(公告)号:DK0985678T3
公开(公告)日:2002-04-02
申请号:DK99203630
申请日:1997-07-22
Applicant: SYMYX TECHNOLOGIES INC
Inventor: MCFARLAND ERIC , TURNER HOWARD , BEEK JOHANNES A M VAN , MURPHY VINCE , POWERS TIMOTHY , WEINBERG HENRY W , BOUSSIE THOMAS , GOLDWASSER ISY
IPC: B01J23/22 , B01J19/00 , B01J31/16 , B01J31/22 , B01J37/00 , C07B61/00 , C07C249/02 , C07C251/08 , C07C251/16 , C07D213/53 , C07F15/00 , C07F15/04 , C07F17/00 , C07F19/00 , C08F4/00 , C08F4/60 , C08F4/70 , C08F10/00 , C08F110/02 , C40B40/04 , C40B40/18 , C40B50/00 , C40B60/14 , G01N1/10 , G01N21/64 , G01N29/24 , G01N29/34 , G01N29/44
Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.
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公开(公告)号:DK0983983T3
公开(公告)日:2002-03-25
申请号:DK99203631
申请日:1997-07-22
Applicant: SYMYX TECHNOLOGIES INC
Inventor: MCFARLAND ERIC , TURNER HOWARD , BEEK JOHANNES A M VAN , MURPHY VINCE , POWERS TIMOTHY , WEINBERG HENRY W , BOUSSIE THOMAS , GOLDWASSER ISY
IPC: B01J23/22 , B01J19/00 , B01J31/16 , B01J31/22 , B01J37/00 , C07B61/00 , C07C249/02 , C07C251/08 , C07C251/16 , C07D213/53 , C07F15/00 , C07F15/04 , C07F17/00 , C07F19/00 , C08F4/00 , C08F4/60 , C08F4/70 , C08F10/00 , C08F110/02 , C40B40/04 , C40B40/18 , C40B50/00 , C40B60/14 , G01N1/10 , G01N21/64 , G01N29/24 , G01N29/34 , G01N29/44
Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.
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公开(公告)号:DK0978499T3
公开(公告)日:2002-03-04
申请号:DK99203632
申请日:1997-07-22
Applicant: SYMYX TECHNOLOGIES INC
Inventor: MCFARLAND ERIC , TURNER HOWARD , BEEK JOHANNES A M VAN , MURPHY VINCE , POWERS TIMOTHY , WEINBERG HENRY W , BOUSSIE THOMAS , GOLDWASSER ISY
IPC: B01J23/22 , B01J19/00 , B01J31/16 , B01J31/22 , B01J37/00 , C07B61/00 , C07C249/02 , C07C251/08 , C07C251/16 , C07D213/53 , C07F15/00 , C07F15/04 , C07F17/00 , C07F19/00 , C08F4/00 , C08F4/60 , C08F4/70 , C08F10/00 , C08F110/02 , C40B40/04 , C40B40/18 , C40B50/00 , C40B60/14 , G01N1/10 , G01N21/64 , G01N29/24 , G01N29/34 , G01N29/44
Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.
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公开(公告)号:DE69709179D1
公开(公告)日:2002-01-24
申请号:DE69709179
申请日:1997-07-22
Applicant: SYMYX TECHNOLOGIES INC
Inventor: WEINBERG HENRY W , MCFARLAND ERIC , GOLDWASSER ISY , BOUSSIE THOMAS , TURNER HOWARD , BEEK JOHANNES A M VAN , MURPHY VINCE , POWERS TIMOTHY
IPC: B01J23/22 , B01J19/00 , B01J31/16 , B01J31/22 , B01J37/00 , C07B61/00 , C07C249/02 , C07C251/08 , C07C251/16 , C07D213/53 , C07F15/00 , C07F15/04 , C07F17/00 , C07F19/00 , C08F4/00 , C08F4/60 , C08F4/70 , C08F10/00 , C08F110/02 , C40B40/04 , C40B40/18 , C40B50/00 , C40B60/14 , G01N1/10 , G01N21/64 , G01N29/24 , G01N29/34 , G01N29/44
Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.
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公开(公告)号:AT210108T
公开(公告)日:2001-12-15
申请号:AT99203630
申请日:1997-07-22
Applicant: SYMYX TECHNOLOGIES INC
Inventor: WEINBERG HENRY W , MCFARLAND ERIC , GOLDWASSER ISY , BOUSSIE THOMAS , TURNER HOWARD , BEEK JOHANNES A M VAN , MURPHY VINCE , POWERS TIMOTHY
IPC: B01J23/22 , B01J19/00 , B01J31/16 , B01J31/22 , B01J37/00 , C07B61/00 , C07C249/02 , C07C251/08 , C07C251/16 , C07D213/53 , C07F15/00 , C07F15/04 , C07F17/00 , C07F19/00 , C08F4/00 , C08F4/60 , C08F4/70 , C08F10/00 , C08F110/02 , C40B40/04 , C40B40/18 , C40B50/00 , C40B60/14 , G01N1/10 , G01N21/64 , G01N29/24 , G01N29/34 , G01N29/44
Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.
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