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公开(公告)号：CA3071058A1
公开(公告)日：2010-09-23
申请号：CA3071058
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D307/83 , C07C68/06 , C07D215/56
Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 2; in the presence of a coupling agent.
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公开(公告)号：CA2756031A1
公开(公告)日：2010-09-23
申请号：CA2756031
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.
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公开(公告)号：CA2852991C
公开(公告)日：2019-12-31
申请号：CA2852991
申请日：2012-11-08
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , LITTLER BENJAMIN JOSEPH , CHOUDHURY ANUSUYA , HARRISON CRISTIAN L , VELURI RAVIKANTH , RYAN MICHAEL P , JIANG LICONG , LUSS-LUSIS EDUARD
IPC: C07D405/12 , A61K31/405 , A61K31/553 , A61P1/00 , A61P3/00 , A61P11/00 , A61P25/00 , A61P27/00 , A61P35/00 , C07D405/14 , C07D498/04
Abstract: Compounds of the present invention, are presented by the following formula: or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, Y and R4 are as described herein, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：AU2018204671A1
公开(公告)日：2018-07-12
申请号：AU2018204671
申请日：2018-06-27
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA J , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP GUERETTE DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X H R2 Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.
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35.发明专利
公开(公告)号：ES2654414T3
公开(公告)日：2018-02-13
申请号：ES14182117
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT LANGILLE BOBBIANA , TRUDEAU MARTIN , ROPER STEFANIE , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: Un proceso para la preparación de un compuesto de Fórmula 8 **(Ver fórmula)** que comprende nitrar un compuesto de Fórmula 7 usando una mezcla de ácido sulfúrico y ácido nítrico en presencia de diclorometano **(Ver fórmula)** en el que PG es un grupo protector y R2 y R4 son cada uno terc-butilo, y en el que el compuesto nitro de Fórmula 8 se purifica por cristalización, en el que PG es propoxiformilo, metanosulfonilo, 4-nitro-benzoílo, etoxiformilo, butoxiformilo, t-butoxiformilo, i-propoxiformilo o metoxiformilo.
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Patent Agency Ranking
公开(公告)号：ME02650B
公开(公告)日：2017-06-20
申请号：MEP201772
申请日：2012-11-08
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , LITTLER BENJAMIN JOSEPH , CHOUDHURY ANUSUYA , HARRISON CRISTIAN , VELURI RAVIKANTH , RYAN MICHAEL P , JIANG LICONG , LUSS-LUSIS EDUARD
IPC: A61K31/405 , A61K31/553 , A61P1/00 , A61P3/00 , A61P11/00 , A61P25/00 , A61P27/00 , A61P35/00 , C07D405/12 , C07D405/14 , C07D498/04
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公开(公告)号：LT2776427T
公开(公告)日：2017-04-10
申请号：LT12794811
申请日：2012-11-08
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , LITTLER BENJAMIN JOSEPH , CHOUDHURY ANUSUYA , HARRISON CRISTIAN , VELURI RAVIKANTH , RYAN MICHAEL P , JIANG LICONG , LUSS-LUSIS EDUARD
IPC: C07D405/12 , A61K31/405 , A61K31/553 , A61P1/00 , A61P3/00 , A61P11/00 , A61P25/00 , A61P27/00 , A61P35/00 , C07D405/14 , C07D498/04
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38.发明专利
公开(公告)号：CY1116954T1
公开(公告)日：2017-04-05
申请号：CY151101043
申请日：2015-11-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: ΗεφεύρεσηπαρέχειμίαμέθοδογιατηνπαρασκευήμίαςένωσηςΤύπου 1•πουπεριλαμβάνεισύζευξηενόςκαρβοξυλικούοξέοςΤύπου 2 μεμίαανιλίνηΤύπου 3•παρουσίαενόςπαράγοντασύζευξης.
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39.发明专利
公开(公告)号：SI2408750T1
公开(公告)日：2015-11-30
申请号：SI201031042
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/00
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40.发明专利
公开(公告)号：HRP20151137T1
公开(公告)日：2015-11-20
申请号：HRP20151137
申请日：2015-10-27
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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