公开(公告)号：LT3345625T

公开(公告)日：2021-02-10

申请号：LT17204189

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/47

公开(公告)号：PL2328618T3

公开(公告)日：2018-06-29

申请号：PL09789125

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/47

公开(公告)号：HRP20180328T1

公开(公告)日：2018-04-20

申请号：HRP20180328

申请日：2018-02-22

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/47

公开(公告)号：CA2733908C

公开(公告)日：2017-05-30

申请号：CA2733908

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N- [2,4-Bis( 1, 1-dimethylethyl)-5 -hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, and a polymer, wherein Compound 1 is present in an amount of about 80% by weight of the solid dispersion.

公开(公告)号：BRPI0916877A2

公开(公告)日：2016-02-10

申请号：BRPI0916877

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： GROSSI ALFREDO ,  YOUNG CHRISTOPHER ,  OVERHOFF KIRK ,  DINEHART KRIK ,  VERWIJS MARINUS JACOBUS ,  BOTFIELD MARTYN ,  HURTER PATRICIA ,  GROOTENHUIS PETER D J ,  ROWE WILLIAM

IPC: A61K47/32

公开(公告)号：NZ591535A

公开(公告)日：2012-12-21

申请号：NZ59153509

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D

IPC: A61K47/32 ,  A61K9/42 ,  A61K31/47

Abstract: Disclosed is a pharmaceutical composition comprising: a solid dispersion of substantially amorphous N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), hydroxypropylmethylcellulose acetate succinate and sodium lauryl sulfate, microcrystalline cellulose, lactose, sodium croscarmellose, SLS, colloidal silicon dioxide, magnesium stearate.

公开(公告)号：NZ586272A

公开(公告)日：2012-05-25

申请号：NZ58627208

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  YOUNG CHRISTOPHER

IPC: A61K31/00 ,  A61K9/00 ,  A61K9/10

Abstract: Disclosed is an aqueous formulation comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid, water, and a viscosity agent, wherein the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid is characterized by one or more peaks at 15.2 to 15.6 degrees, 16.1 to 16.5 degrees, and 14.3 to 14.7 degrees in an X-ray powder diffraction obtained using Cu K alpha radiation. The viscosity agent is selected from the group consisting of methyl cellulose, sodium carboxymethylcellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, sodium alginate, polyacrylate, povidone, acacia, guar gum, xanthan gum, tragacanth, and magnesium aluminium silicate. The composition can further comprise a surfactant. Also disclosed is an oral formulation, the use of the formulation in the manufacture of a medicament for treating cystic fibrosis and a kit comprising the formulation and instructions for use.

公开(公告)号：CL2011000642A1

公开(公告)日：2011-11-25

申请号：CL2011000642

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： YOUNG CHRISTOPHER

IPC: A61K9/48 ,  A61P1/00 ,  A61P3/00

Abstract: Unidad de dosificación que comprende 25 a 400 mg del ácido 3-(6-(1-(2,2-difluorobenzeno[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico; y su uso en la fibrosis quística.

公开(公告)号：MX2010006238A

公开(公告)日：2010-08-11

申请号：MX2010006238

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZSHOKRI ALI ,  YOUNG CHRISTOPHER

IPC: A61K31/443 ,  A61P43/00

Abstract: La presente invención se relaciona con formulaciones del ácido 3-(6-(1-(2,2-difluorobenzo [d][1,3] dioxol-5-il) ciclopropancarboxamido) -3 metilpiridin-2-il) benzoico, empaques o kits farmacéuticos de las mimas y métodos para el tratamiento con las mismas.

公开(公告)号：AU2008335439A1

公开(公告)日：2009-06-18

申请号：AU2008335439

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： YOUNG CHRISTOPHER ,  KESHAVARZ-SHOKRI ALI

IPC: A61K9/10 ,  A61K9/00 ,  A61K31/00

Abstract: The present invention relates to formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid, pharmaceutical packs or kits thereof, and methods of treatment therewith.