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1.发明申请PHARMACEUTICAL COMPOSITION OF N- [2,4-BIS (1, 1 -DIMETHYLETHYL) - 5 - HYDROXYPHENYL] - 1, 4 - DIHYDRO - 4 - OXOQUINOLINE - 3 - CARBOXAMIDE AND ADMINISTRATION THEREOF 审中-公开N- [2,4-BIS（1,1-二甲基）-5-羟基苯基] -1,4-二氢-4-氧杂喹啉-3-羧酰胺的药物组合物及其施用方法
公开(公告)号：WO2010019239A3
公开(公告)日：2011-05-26
申请号：PCT/US2009004629
申请日：2009-08-13
Applicant: VERTEX PHARMA , ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
IPC: A61K47/32
CPC classification number: A61K9/1652 , A61K9/1635 , A61K9/2054 , A61K9/282 , A61K31/47
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- 3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
Abstract translation: 本发明涉及包含N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法 本发明的药物组合物和本发明的药物组合物的给药方法。
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公开(公告)号：AU2021381509A1
公开(公告)日：2023-06-22
申请号：AU2021381509
申请日：2021-11-17
Applicant: VERTEX PHARMA
Inventor： SHI YI , LAI MEI-HSIU , MEDEK ALES , HU KAN-NIAN , SONG ZHENGTIAN , TORRICO GUZMAN ELISA , SOKOLOWSKY KATHLEEN , GIROUX SIMON , LIU SIYING , OVERHOFF KIRK , RODAY SETU , SAWANT RUPA , SPOSATO MARISA
IPC: A61P1/16 , A61K31/416 , A61K31/4162 , A61P11/00 , C07D487/04
Abstract: Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and methods of using and preparing the same for treatment of alpha-1 antitrypsin deficiency (AATD).
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公开(公告)号：HUE053357T2
公开(公告)日：2021-06-28
申请号：HUE17204189
申请日：2009-08-13
Applicant: VERTEX PHARMA
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公开(公告)号：LT3345625T
公开(公告)日：2021-02-10
申请号：LT17204189
申请日：2009-08-13
Applicant: VERTEX PHARMA
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公开(公告)号：CY1121572T1
公开(公告)日：2020-05-29
申请号：CY191100385
申请日：2019-04-08
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: ΗπαρούσαεφεύρεσηαφοράσεφαρμακευτικέςσυνθέσειςπουπεριλαμβάνουνδιασποράστερεούτουΝ-[2,4-Δις(1,1-διμεθυλαιθυλ)-5-υδροξυφαινυλ]-1,4-διυδρο-4-οξοκινολινο-3 καρβοξαμιδίου, μεθόδουςβιομηχανικήςκατασκευήςφαρμακευτικώνσυνθέσεωντηςπαρούσαςεφεύρεσηςκαιμεθόδουςχορήγησηςφαρμακευτικώνσυνθέσεωντηςπαρούσαςεφεύρεσης.
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Patent Agency Ranking
公开(公告)号：SI2464337T1
公开(公告)日：2019-05-31
申请号：SI201031871
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：HRP20190660T1
公开(公告)日：2019-05-31
申请号：HRP20190660
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：PL2328618T3
公开(公告)日：2018-06-29
申请号：PL09789125
申请日：2009-08-13
Applicant: VERTEX PHARMA
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公开(公告)号：HRP20180328T1
公开(公告)日：2018-04-20
申请号：HRP20180328
申请日：2018-02-22
Applicant: VERTEX PHARMA
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公开(公告)号：CA2733908C
公开(公告)日：2017-05-30
申请号：CA2733908
申请日：2009-08-13
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
IPC: A61K47/32
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N- [2,4-Bis( 1, 1-dimethylethyl)-5 -hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, and a polymer, wherein Compound 1 is present in an amount of about 80% by weight of the solid dispersion.
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