公开(公告)号：US20110133101A1

公开(公告)日：2011-06-09

申请号：US12987736

申请日：2011-01-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G01J1/58 ,  G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00117 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086 ,  G02B6/29362 ,  G02B21/16

Abstract: An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber.

Abstract translation: 一种成像装置，包括包括至少一个用于发射至少一个激发光束的发射器的照明模块，包括图像引导件的扫描和注射模块，其近端和远端由多根光纤连接， 扫描和注射光学系统，被配置为将至少一个激发光束从图像引导件的近端交替地注入到图像引导件的光纤中，以及检测模块，包括至少一个检测器，用于检测在 图像引导件的远端。 照明模块和检测模块中的至少一个通过共轭光纤与扫描和注入模块光学共轭。

公开(公告)号：US20090097806A1

公开(公告)日：2009-04-16

申请号：US12249665

申请日：2008-10-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

Abstract: An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.

Abstract translation: 一种成像装置包括：照明模块，包括至少一个用于发射至少一个激发光束的发射器; 扫描和注射模块，包括图像引导件，其近端和远端由多根光纤连接; 扫描和注射光学系统，被配置为从所述图像引导件的近端交替地将所述至少一个激发光束注入到所述图像引导件的光纤中; 检测模块，包括用于检测在图像引导件的远端处收集的光通量的检测器，其中照明模块和检测模块中的至少一个使用共轭光纤与扫描和注射模块光学共轭。

公开(公告)号：US07289204B2

公开(公告)日：2007-10-30

申请号：US10476425

申请日：2002-05-02

Applicant: Hans Ole Nielsen ,  Jan H. Hansen ,  Kim P. Hansen

Inventor： Hans Ole Nielsen ,  Jan H. Hansen ,  Kim P. Hansen

IPC: G01J3/30

CPC classification number: G01N21/6408 ,  G01N21/7703 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6434 ,  G01N2021/6484 ,  G01N2201/086

Abstract: An apparatus and devices for measuring fluorescence lifetimes of fluorescence sensors for one or more analytes, the apparatus comprising (c) one or more reference systems (3,6,7), said reference systems each comprising one or more reference light sources (3) and being adapted to receive one or more excitation signals (1a), to produce reference optical signals (6b) in response thereto, and to produce one or more electrical reference output signals (7b) in response to one or more excitation signals (1a); and (d) or more phase detectors (10), said phase detections being adapted to detect one or more delays of said one or more electrical output signals of said one or more fluorescence sensor systems and said one or more reference systems, and to produce one or more phase output signals; and a method of measuring concentration of one or more analytes using such apparatus and/or devices.

Abstract translation: 一种用于测量一种或多种分析物的荧光传感器的荧光寿命的装置和装置，所述装置包括（c）一个或多个参考系统（3,6,7），所述参考系统各自包括一个或多个参考光源（3） 并且适于接收一个或多个激励信号（1a）以响应于此产生参考光信号（6b），并响应于一个或多个激励信号产生一个或多个电参考输出信号（7b） （1 a）; 和（d）或更多相位检测器（10），所述相位检测器适于检测所述一个或多个荧光传感器系统和所述一个或多个参考系统的所述一个或多个电输出信号的一个或多个延迟，并且产生 一个或多个相位输出信号; 以及使用这种装置和/或装置测量一种或多种分析物的浓度的方法。

公开(公告)号：US5994707A

公开(公告)日：1999-11-30

申请号：US819050

申请日：1997-03-18

Applicant: Edgar A. Mendoza ,  James E. Sorenson ,  Robert A. Lieberman ,  Thomas C. Forrester

Inventor： Edgar A. Mendoza ,  James E. Sorenson ,  Robert A. Lieberman ,  Thomas C. Forrester

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0245 ,  G01N2201/086

Abstract: A low cost portable fiber optic fluorometer is packaged as a personal computer peripheral and is based on interchangeable modules. One embodiment of the fluorometer comprises an excitation source, a detector, a signal processor, frequency source, wavelength selector, and an optical interface. The optical interface is exclusively fiber optic-based, thereby simplifying optical alignment and reducing the cost of the fluorometer. In another embodiment, the excitation source is an inexpensive monochromatic excitation source. In this case, the monochromatic excitation source and the first wavelength selector are preferably removable and replaceable, so that the fluorometer is advantageously able to generate different excitation wavelengths and detect different emission wavelengths. A fluorescence measurement method comprises the steps of generating an excitation signal; transmitting the excitation signal to a system under study which, in response, generates an emission signal; and detecting both the excitation signal and the emission signal with the fluorometer, and then using the detected excitation signal as a reference signal to calibrate the fluorometer and to nullify distortion errors in the emission signal. The use of the excitation signal as a reference signal provides an advantageously simple way to calibrate the fluorometer and to nullify distortion errors in the emission signal. An alternative method allows the precise shapes of the emission signal and the excitation signal to be profiled. The fluorometry method and apparatus can both advantageously be used for performing both direct fluorescence lifetime measurements and for performing phase fluorometry.

Abstract translation: 低成本便携式光纤荧光计作为个人计算机外围设备封装，并且基于可互换的模块。 荧光计的一个实施例包括激发源，检测器，信号处理器，频率源，波长选择器和光学接口。 光接口仅仅是基于光纤的，从而简化了光学对准并降低了荧光计的成本。 在另一个实施例中，激发源是便宜的单色激发源。 在这种情况下，单色激发源和第一波长选择器优选是可移除和可更换的，使得荧光计有利地能够产生不同的激发波长并检测不同的发射波长。 荧光测量方法包括产生激励信号的步骤; 将激励信号传输到被研究的系统，其响应地产生发射信号; 并用荧光计检测激发信号和发射信号，然后使用检测到的激发信号作为参考信号来校准荧光计，并消除发射信号中的失真误差。 使用激励信号作为参考信号提供校准荧光计并消除发射信号中的失真误差的有利的简单方式。 替代方法允许对发射信号和激励信号的精确形状进行轮廓分析。 荧光测定方法和装置可以有利地用于进行直接荧光寿命测量和用于进行相位荧光测定。

公开(公告)号：US5287168A

公开(公告)日：1994-02-15

申请号：US72668

申请日：1993-06-07

Applicant: David Poucher ,  Chilengi Madhusudhan ,  Joaquin M. Otero

Inventor： David Poucher ,  Chilengi Madhusudhan ,  Joaquin M. Otero

IPC: G01N21/27 ,  G01N21/59 ,  G01N21/85 ,  G01N21/53 ,  G01N21/09

CPC classification number: G01N21/8507 ,  G01N2201/086 ,  G01N2201/0866

Abstract: The sensor system monitors solutes in a liquid stream by analyzing the amount of light absorbed in a liquid in a particular wavelength band. The sensor system is arranged for selectability of the type of fiber used for transmission and adjustability of the liquid gap length in the liquid so that individual installations can be arranged with optimum characteristics for sensing particular chemical species in solution by absorption spectroscopy.

Abstract translation: 传感器系统通过分析在特定波长带中的液体中吸收的光量来监测液体流中的溶质。 传感器系统被布置用于可选择性的用于传输的纤维类型和液体间隙长度在液体中的可调节性，使得各个装置可以布置成具有用于通过吸收光谱检测溶液中的特定化学物质的最佳特性。

公开(公告)号：WO2009143217A1

公开(公告)日：2009-11-26

申请号：PCT/US2009/044633

申请日：2009-05-20

Applicant: WATERS TECHNOLOGIES CORPORATION ,  JEANNOTTE, Anthony ,  LEVEILLE, Michael, J. ,  DENECKE, Frank

Inventor： JEANNOTTE, Anthony ,  LEVEILLE, Michael, J. ,  DENECKE, Frank

IPC: G01N1/10

CPC classification number: G01N21/05 ,  G01N35/1095 ,  G01N2021/0346 ,  G01N2201/024 ,  G01N2201/08 ,  G01N2201/086

Abstract: A flow cell for a photometric device includes a module having a body with a distal face defining an annular channel. The body also defines an axial central passage and an axial flow channel. A second module has a body with a proximal face defining an annular channel. The second body also defines an axial flow channel in fluid communication with the first axial flow channel. A light guiding member is within the central passage for exposing a fluid in the flow channels of the modules. An assembly seals an interface between the distal and proximal faces such that the fluid does not leak from the flow channels. The assembly has a metal gasket between the distal and proximal faces, the metal gasket defining a flow path between the flow channels, a first sealing member in the first annular channel and a second sealing member in the second annular channel.

Abstract translation: 用于光度测量装置的流动池包括具有主体的模块，该主体具有限定环形通道的远端面。 主体还限定轴向中心通道和轴向流动通道。 第二模块具有主体，其具有限定环形通道的近端面。 第二主体还限定与第一轴向流动通道流体连通的轴向流动通道。 导光构件在中央通道内部，用于暴露模块的流动通道中的流体。 组件密封远端和近端面之间的界面，使得流体不会从流动通道泄漏。 该组件在远端和近端面之间具有金属垫圈，金属垫圈限定了流动通道之间的流动路径，第一环形通道中的第一密封构件和第二环形通道中的第二密封构件。

公开(公告)号：WO98041845A1

公开(公告)日：1998-09-24

申请号：PCT/US1998/005463

申请日：1998-03-18

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0245 ,  G01N2201/086

Abstract: A low cost portable fiber optic fluorometer (20) is packaged as a personal computer peripheral and is based on interchangeable modules. One embodiment of the fluorometer includes an excitation source (25), a detector (26), a signal processor, a frequency source (23), a wavelength selector (24), and an optical interface (21, 22). The optical interface is exclusively fiber optic-based, simplifying optical alignment and reducing the cost of the fluorometer. The excitation source may be an inexpensive monochromatic excitation source. In this case, the monochromatic excitation source and the wavelength selector (24) are preferably removable and replaceable, so that the fluorometer is advantageously able to generate different excitation wavelengths and detect different emission wavelengths. The fluorometry apparatus can advantageously be used for performing both direct fluorescence lifetime measurements and for performing phase fluorometry.

Abstract translation: 低成本便携式光纤荧光计（20）被封装为个人计算机外围设备，并且基于可互换的模块。 荧光计的一个实施例包括激发源（25），检测器（26），信号处理器，频率源（23），波长选择器（24）和光学接口（21,22）。 光学接口仅仅是基于光纤的，简化了光学对准并降低了荧光计的成本。 激发源可以是便宜的单色激发源。 在这种情况下，单色激发源和波长选择器（24）优选是可移除和可更换的，使得荧光计有利地能够产生不同的激发波长并检测不同的发射波长。 荧光测定装置可以有利地用于进行直接荧光寿命测量和进行相位荧光测定。

公开(公告)号：WO2015048935A1

公开(公告)日：2015-04-09

申请号：PCT/CZ2014/000095

申请日：2014-09-01

Applicant: VYSOKÉ UČENI TECHNICKÉ V BRNĚ

Inventor： ΝOVOΤΝÝ, Jan ,  KAISER, Josef ,  PROČEK, Jan ,  BRADA, Michal ,  PETRILAK, Michal ,  KŘUPKA, Ivan

IPC: G01N21/71

CPC classification number: G01N21/718 ,  G01N21/17 ,  G01N2021/1793 ,  G01N2201/024 ,  G01N2201/086

Abstract: A modular device for remote chemical material analysis with a basic function unit which is formed with a transport module (2), which is partly equipped with a mobile frame construction which is set up with at least a power supply (21) of the laser, a detection system (22), designed for plasma radiation dispersion according to the wavelength and its record, a control and evaluation block (23) in the form of PC and a control electronic block (24) and partly is connected with a laser module (4) which contains a laser head (41), which serves as a source of laser pulses, where the essence of the invention is that the laser module (4) is equipped with a laser beam router (42) of optional routing of laser pulses either into a stand-off module (6) when analyzed with a "Stand-Off LIBS" method or into a fiber module (8) when analyzed with a "Remote LIBS" method.

Abstract translation: 一种用于远程化学材料分析的模块化装置，具有形成有运输模块（2）的基本功能单元，所述运输模块部分地配备有至少设置有所述激光器的电源（21）的移动框架结构， 根据波长及其记录设计用于等离子体辐射色散的检测系统（22），PC和控制电子块（24）形式的控制和评估块（23），并且部分地与激光模块（ 4），其包含用作激光脉冲源的激光头（41），其中本发明的实质是激光模块（4）配备有激光束路由器（42），激光束路由器（42）可选地布置激光脉冲 当用“远程LIBS”方法分析时，当用“Stand-off LIBS”方法分析或者进入光纤模块（8）时，进入待机模块（6）。

公开(公告)号：WO2009053632A2

公开(公告)日：2009-04-30

申请号：PCT/FR2008/051845

申请日：2008-10-10

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE, Bertrand ,  LACOMBE, François ,  BOULAROT, Nicolas ,  DOUSSOUX, François ,  LAVILLONNIERE, Nicolas

IPC: G01N21/64 ,  A61B1/07 ,  G02B21/00 ,  A61B1/00 ,  G01N21/63 ,  A61B5/00 ,  G02B26/10 ,  G02B23/14

CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

Abstract: La présente invention concerne un dispositif d'imagerie, comprenant: un module d'illumination (1) comprenant des moyens pour émettre au moins un faisceau d'excitation; un module de balayage et d'injection (2) comprenant un guide d'image (3) dont deux extrémités respectivement proximale (3a) et distale (3b) sont reliées par une pluralité de fibres optiques, et des moyens (6) de balayage et d'injection agencés pour injecter l'au moins un faisceau d'excitation tour à tour dans une fibre du guide d'image (3) et du côté proximal (3a) du guide; un module de détection (4) comprenant des moyens pour détecter un flux lumineux (14) collecté à l'extrémité distale (3b) du guide. Au moins un parmi le module d'illumination (1) et le module de détection (4) est conjugué optiquement au module de balayage et d'injection (2) par une fibre optique de conjugaison (5, 7). L'utilisation de fibres de conjugaison (5, 7) permet d'améliorer la maintenance, la réparation et la mise à jour du dispositif, et peut en outre permettre de réaliser un filtrage modal du faisceau d'excitation et d'assurer la confocalité du dispositif.

Abstract translation: 本发明涉及一种成像装置，包括：照明模块（1），包括用于发射至少一个激发光束的装置; 包括图像波导（3）的扫描/注射模块（2），其分别的近端（3a）和远端（3b）的两端通过多根光纤连接，扫描/注入 设计成将至少一个激发光束依次注入图像波导（3）的光纤然后进入所述波导的近侧（3a）的装置（6）和包括用于检测光的装置的检测模块（4） 在波导的远端（3b）处收集的通量（14）。 至少照明模块（1）或检测模块（4）经由共轭光纤（5,7）与扫描/注入模块（2）光学共轭。 使用共轭纤维（5,7）能够改善设备的维护，修理和更新。 它还可以实现激发光束的模态滤波，并确保器件是共焦的。

公开(公告)号：US12117389B2

公开(公告)日：2024-10-15

申请号：US17487722

申请日：2021-09-28

Applicant: Cytiva Sweden AB

Inventor： Henrik Svanberg ,  Hanno Ehring ,  Erik Nils Ostlund

IPC: G01N21/05 ,  G02B6/36 ,  G02B6/38 ,  G02B6/42

CPC classification number: G01N21/05 ,  G02B6/3616 ,  G02B6/3644 ,  G02B6/3825 ,  G02B6/3861 ,  G02B6/4219 ,  G01N2021/052 ,  G01N2201/0664 ,  G01N2201/0668 ,  G01N2201/0813 ,  G01N2201/086 ,  G02B6/36

Abstract: The present invention relates to an optical flow cell for a measuring device, having an input light guide with a light exit surface, an output light guide with a light entrance surface, said input light guide and output light guide being integrated with a holder to form an optical flow cell, and wherein the holder extends along a first axis and has a through hole for receiving a flow of a sample fluid, said through hole being transversal to said first axis, and the input light guide and output light guide further are arranged in said holder so that the light exit surface and the light entrance surface extend into said through hole and are arranged to be in optical alignment with each other and at a first distance from each other. The invention also relates to a measuring device having at least one optical flow cell.