公开(公告)号：WO1998024791A1

公开(公告)日：1998-06-11

申请号：PCT/US1997022279

申请日：1997-12-04

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F. ,  WENDT, Michael, D. ,  HAIGHT, Anthony, R. ,  ZHANG, Weijiang

IPC: C07D491/04

CPC classification number: C07D491/04

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1肾上腺素受体并治疗BPH的方法。

公开(公告)号：WO1998022450A1

公开(公告)日：1998-05-28

申请号：PCT/US1997021080

申请日：1997-11-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BONK, Peter, J.

IPC: C07D263/48

CPC classification number: C07D263/48

Abstract: The present invention relates to the production of pemoline (2-imino-5-phenyl-4-oxazilidinone) and its intermediates, reacting a cyanamide containing compound in a sodium alkoxide solution to form a reaction mixture. The reaction mixture is then added to an alkyl mandelate-solvent solution. The resultant reaction mixture is then acidified to a pH of 6.0 or less to precipitate a pemoline product.

Abstract translation: 本发明涉及制备糠基（2-亚氨基-5-苯基-4-恶唑烷酮）及其中间体，使含氰胺的化合物在醇钠溶液中反应形成反应混合物。 然后将反应混合物加入到扁桃酸丁酯溶剂溶液中。 然后将所得反应混合物酸化至pH 6.0以下，沉淀出苯甲醇产物。

公开(公告)号：WO1998020352A2

公开(公告)日：1998-05-14

申请号：PCT/US1997020075

申请日：1997-11-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GORDON, Julian

IPC: G01N33/543

CPC classification number: G01N1/405 ,  B01J3/006 ,  B01L3/502 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5635 ,  G01N1/4077 ,  G01N33/53 ,  G01N2001/007 ,  G01N2001/4088 ,  Y10T436/25375 ,  Y10T436/255

Abstract: A method and apparatus for collecting a binding member of interest from a liquid specimen utilize a collection receptacle in which the specimen is deposited, with an affinity-filter media being placed in communication with a discharge port in the collection receptacle and a transfer device for drawing specimen from the collection receptacle and through the filter for capturing the binding member of interest. The collection receptacle, affinity-filter media and carrier therefor and the transfer device may be supplied in kit form for use in a clinical environment. A hypobaric vessel may be used and the transfer device and this vessel may also serve as a disposal receptacle for the liquid specimen passed through the filter media.

Abstract translation: 用于从液体样品收集感兴趣的结合构件的方法和装置利用其中沉积样本的收集容器，亲和过滤介质被放置成与收集容器中的排出口连通，以及用于绘制的传送装置 来自收集容器的样本和用于捕获感兴趣的结合构件的过滤器。 收集容器，亲和过滤介质及其载体以及转移装置可以以套件形式提供，以用于临床环境。 可以使用低压容器，并且转移装置和该容器也可以用作通过过滤介质的液体样品的处理容器。

公开(公告)号：WO1998018945A1

公开(公告)日：1998-05-07

申请号：PCT/US1997019836

申请日：1997-10-31

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12N15/63

CPC classification number: C07K16/3015 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Abstract translation: 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，称为BS106并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合BS106编码的多肽或蛋白质的抗体，以及预防组织特异性BS106多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：WO1998015657A1

公开(公告)日：1998-04-16

申请号：PCT/US1997018290

申请日：1997-10-08

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  COHEN, Maurice ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C12Q01/68

CPC classification number: C07K14/82 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57434

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS 112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS 112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS 112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS 112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumours or metastases.

Abstract translation: 描述了一组由其编码的连续和部分重叠的RNA序列和多肽，称为PS 112并从前列腺组织转录。 还公开了表示PS 112的连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和状况（例如前列腺癌）的倾向。 还提供了特异性结合PS 112编码的多肽或蛋白质的抗体，以及预防组织特异性PS 112多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

公开(公告)号：WO1998010665A1

公开(公告)日：1998-03-19

申请号：PCT/US1997016081

申请日：1997-09-11

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SUH, John, D. ,  OSTROM, Karin, M. ,  NDIFE, Louis, I. ,  ANLOAGUE, Paul, S. ,  CHURMA, James, N. ,  DAAB-KRZYKOWSKI, Andre ,  JOHNS, Paul, W. ,  GARCIA, Diane, M. ,  MAZER, Terrence, B. ,  MEI, Fu-I

IPC: A23J03/14

CPC classification number: A23J3/16 ,  A23J3/14 ,  A23L5/273 ,  A23L11/34

Abstract: The present invention relates generally to a process of isolating isoflavones/phytoestrogens from a plant protein and producing plant proteins for use in nutritional products that have reduced levels of phytoestrogens, manganese and/or nucleotides. More specifically, this invention is directed to a process of using ion exchange technology to remove phytoestrogens, manganese or nucleotides from plant proteins. Either the removed phytoestrogens or the treated plant protein may be retained for further processing. The phytoestrogens have utility as pharmaceuticals. The treated plant protein has utility in nutritional products. This invention is also directed to isoflavones prepared by the process, to plant protein products resulting from the inventive process, and to nutritional products that use the plant protein product as a source of amino nitrogen.

Abstract translation: 本发明一般涉及从植物蛋白中分离异黄酮/植物雌激素并产生植物蛋白的方法，所述植物蛋白用于具有降低的植物雌激素，锰和/或核苷酸水平的营养产品。 更具体地，本发明涉及使用离子交换技术从植物蛋白中去除植物雌激素，锰或核苷酸的方法。 被去除的植物雌激素或经处理的植物蛋白质可被保留用于进一步处理。 植物雌激素作为药物具有实用性。 经处理的植物蛋白质可用于营养产品。 本发明还涉及通过该方法制备的异黄酮，用于植入由本发明方法产生的蛋白质产物，以及使用植物蛋白产物作为氨基氮源的营养产品。

公开(公告)号：WO1998007753A1

公开(公告)日：1998-02-26

申请号：PCT/US1997014666

申请日：1997-08-19

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Steven, D.

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K39/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K2319/00

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as mammaglobin and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to mammaglobin-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific mammaglobin polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Abstract translation: 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，被称为乳腺球蛋白并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合乳腺球蛋白编码的多肽或蛋白质的抗体，以及预防组织特异性乳腺球蛋白多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

公开(公告)号：WO1998000410A1

公开(公告)日：1998-01-08

申请号：PCT/US1997008506

申请日：1997-05-19

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OLIVER, Patricia, A. ,  COOPER, Arthur, J. ,  LALLAMAN, John, E. ,  LANDGRIDGE, Denton, C. ,  TIEN, Jieh-Heh, J.

IPC: C07D277/28

CPC classification number: C07D277/28

Abstract: A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-amino acid derivatives.

Abstract translation: 公开了制备N - （（N-甲基-N - （（2-异丙基-4-噻唑基）甲基）氨基）羰基） - 氨基酸衍生物的方法。

公开(公告)号：WO1997041256A2

公开(公告)日：1997-11-06

申请号：PCT/US1997007014

申请日：1997-04-25

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GRANADOS, Edward, N. ,  BOUMA, Stanley, R. ,  CARRINO, John, J. ,  SOLOMON, Natalie, A.

IPC: C12Q01/68

CPC classification number: C12Q1/6825 ,  C12Q2563/173 ,  C12Q2537/143 ,  C12Q2521/301

Abstract: Provided herein are methods for detecting multiple target nucleic acid sequences in a test sample. Also provided is a hybridization platform useful for detecting multiple target sequences in a test sample. The hybridization platform comprises a solid support material having a defined pattern of capture probes immobilized thereon.

Abstract translation: 本文提供了用于在测试样品中检测多个靶核酸序列的方法。 还提供了可用于检测测试样品中的多个靶序列的杂交平台。 杂交平台包含具有固定在其上的捕获探针的限定图案的固体支持材料。

公开(公告)号：WO1997041100A1

公开(公告)日：1997-11-06

申请号：PCT/US1997004981

申请日：1997-03-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BROOKS, C., D., W. ,  CRAIG, Richard, A. ,  GUNN, David, E. ,  KOLASA, Teodozyj ,  MOORE, Jimmie, L. ,  STEWART, Andrew, O.

IPC: C07D209/12

CPC classification number: C07D213/30 ,  C07C317/22 ,  C07C323/19 ,  C07C2602/08 ,  C07D209/12 ,  C07D257/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

Abstract: The present invention provides a class of substituted indole and indene iminoxy derivatives of formulae (I), (II) and (III) which inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states.

Abstract translation: 本发明提供一类抑制白三烯生物合成的式（I），（II）和（III）的吲哚和茚亚氨基衍生物，并且可用于治疗过敏性和炎性疾病状态。