公开(公告)号：DK2654793T3

公开(公告)日：2017-12-18

申请号：DK11852145

申请日：2011-12-21

Applicant: LEIDOS INC

Inventor： DRESIOS JOHN ,  GRIFFEY RICHARD

IPC: G01N33/50 ,  G01N33/567

公开(公告)号：AU2011205219B2

公开(公告)日：2011-11-24

申请号：AU2011205219

申请日：2011-08-09

Applicant: UNIV GEORGETOWN ,  LEIDOS INC

Inventor： CURRIE JOHN F ,  MAKARAND PARANJAPE ,  PECK CARL C ,  WHITE ROBERT C ,  SCHNEIDER THOMAS W

IPC: A61B5/00 ,  G01N1/10 ,  G01N33/48 ,  G01N33/53 ,  G01N37/00

Abstract: Abstract The present invention pertains to a system and method for transdennal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for: (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector. 7 7 --- - - - h. ILn -Lk. -

公开(公告)号：AU2010200890C1

公开(公告)日：2011-09-01

申请号：AU2010200890

申请日：2010-03-10

Applicant: UNIV GEORGETOWN ,  LEIDOS INC

Inventor： CURRIE JOHN F ,  MAKARAND PARANJAPE ,  PECK CARL C ,  WHITE ROBERT C ,  SCHNEIDER THOMAS W

IPC: A61B5/00 ,  G01N33/48 ,  G01N1/10 ,  G01N33/53 ,  G01N37/00

Abstract: Abstract The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for: (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector. C ) C r---4 If)

公开(公告)号：AU2022215566A9

公开(公告)日：2025-01-30

申请号：AU2022215566

申请日：2022-02-02

Applicant: GEOVAX INC ,  LEIDOS INC

Inventor： HAUSER MARY JO ,  DOMI ARBAN ,  GUTIERREZ GABRIEL ,  PANNUCCI JAMES ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY ,  BUONTEMPO PETER ,  BROWNE CECILLE

IPC: A61K35/768 ,  C12N15/86 ,  C12N15/87 ,  C12N15/90

Abstract: The invention provides virus-based expression vectors comprising immune-checkpoint inhibitor inserts for use as effective adjuvants in enhancing T-cell priming to an antigen in a host during a vaccination regimen. In particular, the compositions described herein are novel recombinant modified vaccinia Ankara (MVA) viral constructs encoding one or more peptides which, upon administration, are expressed in a multimer conformation and subsequently cleaved and secreted from the cell. Such peptides are capable of downregulating an immune checkpoint pathway, for example, by inhibiting the activation of programmed-cell death protein 1 (PD-1), programed cell death ligand 1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), or another immune checkpoint regulator, or a combination thereof. When used in concert with the administration of an antigen during a vaccination strategy, the immune checkpoint expressing MV A viral construct provides significantly improved antigen-specific CD8+ T cell expansion, increased antigenic responses, and improved vaccination efficacy.

公开(公告)号：AU2019263158B2

公开(公告)日：2023-12-14

申请号：AU2019263158

申请日：2019-04-30

Applicant: LEIDOS INC

Inventor： CHRISTIAN NOAH PETER

IPC: H01J49/04

Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

公开(公告)号：AU2020279371A1

公开(公告)日：2021-12-23

申请号：AU2020279371

申请日：2020-05-21

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY W ,  PANNUCCI JAMES ,  MANSOUR MARC

IPC: A61P35/00 ,  A61P25/28 ,  C07K7/00

Abstract: This disclosure provides peptides which bind to LAG3 and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.

公开(公告)号：AU2019299339A1

公开(公告)日：2021-01-21

申请号：AU2019299339

申请日：2019-07-01

Applicant: LEIDOS INC

Inventor： CHAPPELL STEPHEN A ,  MAURO VINCENT P ,  DRESIOS JOHN

IPC: C12P21/00 ,  C07H21/04 ,  C12N15/00 ,  C12P21/04 ,  C12P21/06 ,  C12Q1/68

Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.

公开(公告)号：AU2018410849A1

公开(公告)日：2020-09-10

申请号：AU2018410849

申请日：2018-02-28

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PANNUCCI JAMES ,  AYALA RAMSES

IPC: A61K38/10 ,  A61K38/16 ,  A61K48/00 ,  A61P17/00 ,  A61P17/02 ,  A61P31/00 ,  A61P31/04 ,  A61P35/00 ,  A61Q5/00 ,  A61Q19/02 ,  C12N15/00

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor programmed death 1 (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

公开(公告)号：CA3104859A1

公开(公告)日：2020-01-09

申请号：CA3104859

申请日：2019-07-01

Applicant: LEIDOS INC

Inventor： CHAPPELL STEPHEN A ,  MAURO VINCENT P ,  DRESIOS JOHN

IPC: C12P21/00 ,  C07H21/04 ,  C12N15/00 ,  C12P21/04 ,  C12P21/06 ,  C12Q1/68

Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.

公开(公告)号：CA3091414A1

公开(公告)日：2019-09-06

申请号：CA3091414

申请日：2018-02-28

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PANNUCCI JAMES ,  AYALA RAMSES

IPC: A61K38/10 ,  A61K38/16 ,  A61K48/00 ,  A61P17/00 ,  A61P17/02 ,  A61P31/00 ,  A61P31/04 ,  A61P35/00 ,  A61Q5/00 ,  A61Q19/02 ,  C12N15/00

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor programmed death 1 (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.