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    NEW PHARMACEUTICAL COMPOSITION FOR PROTECTING GASTRODUODENAL MUCOSA
    46.
    发明专利
    NEW PHARMACEUTICAL COMPOSITION FOR PROTECTING GASTRODUODENAL MUCOSA 失效

    公开(公告)号：JPH04321629A

    公开(公告)日：1992-11-11

    申请号：JP1683391

    申请日：1991-01-18

    Applicant: SCLAVO SPA

    Inventor： RUKA PARENTE ,  KENISU MAGURITSUJI ,  JIYON WARESU ,  KIYASARIN KIINAN

    IPC: A61K38/00 ,  A61K31/60 ,  A61K38/20 ,  A61P1/04

    Abstract: PURPOSE: To prepare a gastroduodenal protector for treating benign relapsing and postoperative ulcers comprising a human interleukin-1β (IL-1β) as an active ingredient. CONSTITUTION: This pharmaceutical composition comprises a compound having an amino acid sequence corresponding to an amino acid sequence of a human IL-1β, e.g. a recombinant human IL-1β or a human IL-1β isolated from a human leukocyte as an active ingredient. The human IL-1β is prepared as a dosage form suitable for oral, intravenous or parenteral administration and the daily dose of the compound contained in the pharmaceutical preparation is usually 0.1-10μg based on 1kg body weight. In the case of the oral administration, the compound is formulated in combination with a nonsteroidal antiinflammatory agent selected from salicylic acid, indomethacin, ibuprofen and piroxicam in a therapeutically effective amount in order to antagonize the gastrolesive effects of the human IL-1β.

    BUFFER CONTAINING COLLAGENASE, ITS PREPARATION AND USE AS HUMAN-SERUM DILUTION
    47.
    发明专利
    BUFFER CONTAINING COLLAGENASE, ITS PREPARATION AND USE AS HUMAN-SERUM DILUTION 失效

    公开(公告)号：JPH04232463A

    公开(公告)日：1992-08-20

    申请号：JP16620191

    申请日：1991-06-12

    Applicant: SCLAVO SPA

    Inventor： PAORO FUABURITSUTSUI ,  FURANCHIESUKO DOTSUNIINI

    IPC: C12Q1/37 ,  C12Q1/42 ,  G01N33/53 ,  G01N33/531 ,  G01N33/564 ,  G01N33/569 ,  G01N33/573

    Abstract: PURPOSE: To make it possible to bond IgM and the like by the operation of collagenase contained by using buffer solution having specific pH and containing collagenase existing in specific concentration with TV type collagnase to dilute serum. CONSTITUTION: Buffer liquid contains collagenase, has a pH of 7.0 to 7.4 so that the collagenase is IV type collagenase, which is existed in concentration of 1000 to 3000 U/l. The liquid contains, for example, 1.09g/1 of sodium biphosphate anhydride, 0.37g/l of sodium phosphate hydride, 8.5g/l of sodium chloride, 10g/l of borine serum albumin, 0.5g/l of Brij 35, 0.5/l of aggregate human IgG, 1500U/l of collagenase IV, and 1.00g/l of sodium azide. When the liquid is used to dilute serum, the collagnase enzyme contained therein is operated at the amino acid sequence of Clq capable of bonding IgM and the like.

    ANHYDROUS PHARMACEUTICAL PREPARATION AND ITS DOSAGE FORM FOR RECTAL ADMINISTRATION OF CALCITONIN
    49.
    发明专利
    ANHYDROUS PHARMACEUTICAL PREPARATION AND ITS DOSAGE FORM FOR RECTAL ADMINISTRATION OF CALCITONIN 失效

    公开(公告)号：JPH03190824A

    公开(公告)日：1991-08-20

    申请号：JP30895790

    申请日：1990-11-16

    Applicant: SCLAVO SPA

    Inventor： FUIRITSUPO RATSUTANTSUI ,  RITSUKARUDO BUANNI

    IPC: A61K9/08 ,  A61K9/48 ,  A61K38/23 ,  A61K47/10 ,  A61K47/34 ,  A61K47/42 ,  A61P3/00

    Abstract: PURPOSE: To obtain a stable pharmaceutical preparation suitable for preparation of capsules for rectal administration by dispersing calcitonin and, as necessary, as stabilizer into a liquid vehicle comprising polyethylene glycol and a polyhydric alcohol. CONSTITUTION: This pharmaceutical preparation is obtained by dispersing (C) calcitonin in an amount of 20-800IU, preferably 50-500IU based on 1ml preparation, and necessary, (D) a stabilizer, preferably albumin in an amount of 0.01-1.2mg, preferably 0.05-1.0mg based on 1IU component C into a uniform liquid vehicle comprising (A) polyethylene glycol in an amount of >=75wt.%, especially >=85wt.% based on total weight of the preparation and (B) an alcohol having at least two hydroxy groups, preferably propylene glycol, ethylene glycol, sorbitol, especially glycerol in an amount of

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