Abstract:
PURPOSE: A composition containing mesenchymal stem cells for treating autoimmune diseases is provided to improve immunity and to prevent dermatitis which is a side effect of a steroid formulation, thereby being used as a safety therapeutic agent for treating autoimmune diseases. CONSTITUTION: A composition for treating autoimmune diseases contains mesenchymal stem cells. The composition treats autoimmune diseases by promoting the generation or activation of regulatory B cells or suppressing the generation of antibody producing B cells. The regulatory B cells are B reg or B10 cells. The B cells are CD19+CD1d+CD5+ B cells or marginal zone B cells.
Abstract:
PURPOSE: A composition containing myeloid derived suppressor cells as active ingredients for preventing or treating transplant rejection or autoimmune diseases is provided to promote generation of regulatory B cells and activation of antibody-producing B cells, thereby treating immune diseases including autoimmune diseases. CONSTITUTION: A composition for preventing or treating transplant rejection or autoimmune diseases contains myeloid derived suppressor cells. Myeloid derived suppressor cells are isolated and differentiated from bone marrow of an individual with immune diseases. The composition promotes generation of regulatory B cells or suppresses activation of antibody-producing B cells. Myeloid derived suppressor cells are differentiated by GM-CSF or M-CSF. Myeloid derived suppressor cells have CD11b^+Gr-1^+ marker by induction of differentiation.
Abstract:
PURPOSE: A cell therapeutic composition is provided to effectively suppress immune rejection from a transplant process, and to prevent or treat graft-versus-host disease. CONSTITUTION: A pharmaceutical composition for preventing or treating graft-versus-host disease contains 1ug/ul-3ug/ul of genes which suppresses an IL-21 receptor and 2x10^5-2x10^7 mesenchymal stem cells as an active ingredient. The mesenchymal stem cells are derived from human.
Abstract:
본발명은메트포민및 스타틴의복합제를이용한자가면역질환의예방또는치료용조성물에관한것이다. 본발명에따른메트포민및 스타틴을유효성분으로포함하는복합제인자가면역질환의예방또는치료용약학적조성물은염증성사이토카인의생성을효과적으로억제시킬수 있고, 항체생산 B 세포의생성을저해또는활성을감소시킬수 있으며, 파골세포의분화를억제하고관절파괴를억제하는효과를가지며동맥경화반(Artherosclerotic plaque) 전구세포를형성하는거품세포(Foam cell)의생성억제효과가뛰어나메트포민및 스타틴을유효성분으로하는복합제는자가면역질환의치료제로서매우유용하게활용될수 있다.
Abstract:
본발명의다우리놀화합물은염증반응을유발시키는염증성사이토카인인 IL-17 및 TNF-α의생성을억제하는활성이우수하여관절염및 염증성장 질환에탁월한치료효과를나타내고, 동종반응성 T 세포의증식을억제하고조절 T 세포를증가시켜이식후 거부반응을완화시킬수 있어, 본발명에따른다우리놀화합물은면역질환을치료및 예방할수 있는약학적조성물로활용가능하다. 또한, 본발명의다우리놀화합물은몽골약용식물인하플로필럼다우리쿰(Haplophyllum dauricum) 또는하플로필럼카파도시쿰(Haplophyllum cappadocicum)으로부터유래한천연물질로세포에독성을유발하지않기때문에면역질환을예방및 개선할수 있는기능성건강식품용조성물로활용할수 있을것이다.