-
41.发明公开알파-토코페롤 및 베타-사이클로덱스트린 포접체와 아마유 또는 아마종실을 포함하는 사료첨가제 조성물 有权含有ALPHA-TOCOPHEROL和FLAXSEED油或FLAXSEED-ENCAPSULATED BETA-CYCLODEXTRTRIN的饲料添加剂组合物
公开(公告)号：KR1020160029707A
公开(公告)日：2016-03-15
申请号：KR1020150125231
申请日：2015-09-04
Applicant: 서울대학교산학협력단 , 주식회사 에스피씨삼립
IPC: A23K1/16 , C07D311/72 , C08B37/16 , A23K1/18
Abstract: 본발명은알파-토코페롤(α-Tocopherol)을코어에포함하며, 상기코어주위를베타-사이클로덱스트린(β-cyclodextrin; β-CD) 및유화제로둘러싸는것을특징으로하는알파-토코페롤(α-Tocopherol) 포접체에대한것으로서, 혼합유화제와베타-사이클로덱스트린을이용하여알파-토코페롤포접체를형성하고, 상기포접체와아마유또는아마종실을포함하는사료첨가제조성물에관한것이다. 베타-사이클로덱스트린에포접된알파-토코페롤과아마종실을동시에이용함으로써, 저장및 운송기간동안의보존률을높이고급여시 체내에서의전달효율및 흡수효율이증진할수 있는사료첨가제를개발할수 있다. 최종적으로는이를산란계사료로이용함으로써계란내의오메가-3지방산및 항산화물질의함량을높일수 있다. 따라서본 발명은산란계용기능성사료개발분야에이용될것이며, 알파-토코페롤포접체는더 나아가식품및 제약분야에서도응용이가능할것이다.
Abstract translation: 本发明涉及一种α-生育酚包合物，其包括核心中的α-生育酚和包围β-环糊精（β-CD）和乳化剂的核心。 该化合物通过使用β-CD和混合乳化剂形成α-生育酚包合物形成，并且饲料添加剂组合物包括化合物，亚麻籽油和亚麻籽。 本发明同时使用与β-CD和亚麻籽结合的α-生育酚，以提高体内的保存时间，转移效率和吸收效率。 饲料添加剂组合物可用于产蛋鸡饲料中，以增加蛋中ω-3脂肪酸和抗氧化剂的含量。 因此，本发明可用于开发产蛋鸡的功能饲料，而α-生育酚包合物用于食品和制药领域。
-
公开(公告)号：KR1020160000949A
公开(公告)日：2016-01-06
申请号：KR1020140078168
申请日：2014-06-25
Applicant: 서울대학교산학협력단
Abstract: 본발명은수용성 RANKL를분비하는재조합유산균및 이의이용에관한것으로, 보다상세하게는본 발명에따른재조합유산균은수용성 RANKL를장내에분비하여 peyer's patch 발달및 M세포분화를활성화시킴으로써, 소장내 항원을흡수하는점막면역반응을유도하는데탁월한효과를나타내는것을확인하였다. 따라서, 본발명의수용성 RANKL를분비하는재조합유산균을유효성분으로포함하는조성물을면역증강용보조제로이용하면, 소장점막면역반응을효율적으로유도하고경구백신의소장점막에서낮은흡수효율의문제점을해결함으로써, 경구백신의효과를증진시킬수 있다.
Abstract translation: 本发明涉及用于分泌水溶性RANKL的重组乳酸菌及其应用。 更具体地说，根据本发明，重组乳酸菌在肠内吸收抗原的粘膜免疫应答的效果优良，通过在肠内分泌水溶性RANKL，活化斑驳补片的发育和分化 M细胞。 因此，当将包含用于分泌作为本发明的活性成分的水溶性RANKL的重组乳酸菌的组合物用作增强免疫力的补充剂时，可以通过在肠中有效诱导粘膜免疫应答来增加口服疫苗的效果 并解决口腔疫苗在肠粘膜中吸收效率低的问题。
-
43.发明公开
公开(公告)号：KR1020150046813A
公开(公告)日：2015-05-04
申请号：KR1020130126051
申请日：2013-10-22
Applicant: 서울대학교산학협력단
Abstract: 본발명은 M 세포표적형 mIL-6를분비하는형질전환유산균주및 재조합단백질에관한것으로서본 발명은 mIL-6 및 M 세포특이펩타이드를각각클로닝한다음발현벡터에삽입하는단계와; 상기발현벡터에 Usp45 분비신호를도입하고형질전환유산균주를구축하는단계와; 상기형질전환유산균주에서면역활성물질을발현시켜분비검정하는단계와; 상기형질전환유산균주의생리활성특징및 단백질분비효율을검정하는단계와; 상기면역조절단백질의활성을에서평가하고에서 M세포표적능을확인하는단계로구성된다. 따라서본 발명은 mIL6 단백질과 M 세포특이펩타이드가도입된신규한재조합발현벡터및 상기신규의재조합발현벡터가도입된형질전환유산균주를제공하여점막면역반응을보다강하게유도할수 있는재조합단백질분비형질전환유산균주와이를유효성분으로함유하는면역증강용경구투여용백신을제공하는뛰어난효과가있다.
Abstract translation: 本发明涉及转化的分泌乳酸杆菌的M细胞靶向mIL-6和重组蛋白。 本发明包括以下步骤：克隆每个mIL-6和M细胞特异性肽，然后将其插入表达载体中; 在将表达载体引入Usp45的分泌信号后，构建转化的乳酸杆菌; 在转化的乳杆菌中表达和分泌测试免疫活性物质; 测试转化的乳杆菌的生物活性特征和蛋白质分泌效率; 并在体外评估免疫控制蛋白的激活后，确认体内M细胞的靶向能力。 因此，本发明提供了引入了mIL6蛋白和M细胞特异性肽的新的重组表达载体以及用新的重组表达载体引入的转化的乳杆菌。 因此，提供能够强烈诱导粘膜免疫反应的重组蛋白分泌转化的乳酸杆菌，以及用于口服注射用于增强含有与活性成分相同的免疫系统的疫苗。
-
公开(公告)号：KR1020140043962A
公开(公告)日：2014-04-14
申请号：KR1020120106125
申请日：2012-09-24
Applicant: 서울대학교산학협력단
CPC classification number: A61K48/0041 , A61K47/26 , A61K47/56 , B82Y5/00 , C12N15/111
Abstract: The present invention relates to a biodegradable polymannitol-based osmotically gene transporter (PMT) and gene therapy using the same. The biodegradable PMT of the present invention includes an osmotic mannitol skeleton, increases membrane permeability by giving osmotic pressure to a cell membrane and shows drastically enhanced transformation efficiency by promoting intracellular intake course. In addition, the PMT of the present invention shows high combining power with DNA, effectively protects the DNA from nuclease, shows chemicophysical characteristics suitable for using as the gene transporter with increased duration in cytoplasmic, and can be useful as the gene transporter for gene therapy by expressing low cytotoxicity in vitro and in vivo.
Abstract translation: 本发明涉及可生物降解的聚甘露糖醇基渗透基因转运蛋白（PMT）和使用其的基因治疗。 本发明的生物降解性PMT包括渗透性甘露醇骨架，通过向细胞膜施加渗透压而提高膜通透性，并通过促进细胞内摄取过程显着提高转化效率。 此外，本发明的PMT与DNA显示出高的结合力，有效地保护DNA免受核酸酶的影响，显示出适合用作基因转运蛋白的化学物理特性，其在细胞质中具有增加的持续时间，并且可用作基因治疗的基因转运蛋白 通过在体外和体内表达低细胞毒性。
-
Patent Agency Ranking
公开(公告)号：KR1020140023455A
公开(公告)日：2014-02-27
申请号：KR1020120088057
申请日：2012-08-10
Applicant: 주식회사 마니커 , 서울대학교산학협력단
Abstract: The present invention relates to CLA-containing functional chicken meat using PCLA addictive feed for chickens and a production method, which can produce low fat chicken meat containing PCLA by feeding 3-6 weeks-old chickens with feed which PCLA, which is 1.71-5.1% of the whole feed weight, is added. [Reference numerals] (AA) Total feeding period(42 days); (BB) Initial period(7 days); (CCF) Former period(14 days); (DD) Later period(11 days); (EE) Later period extension(10 days); (FF) Start of an experiment; (GG) Start for feeding added PCLA; (HH) First sampling; (II) 6 weeks; (JJ) End a second sampling experiment
Abstract translation: 本发明涉及用于鸡的PCLA成瘾饲料的含CLA的功能性鸡肉和一种生产方法，其可以通过给3-6周龄的鸡喂养含有PCLA的低脂鸡肉，其中PCLA为1.71-5.1 加入全部饲料重量的％。 [参考数字]（AA）总喂养期（42天）; （BB）初始期（7天）; （CCF）前期（14天）; （DD）后期（11天）; （EE）后期延期（10天）; （FF）开始实验; （GG）开始喂养PCLA; （HH）第一次抽样; （二）6周; （JJ）结束第二次抽样实验
-
公开(公告)号：KR1020140019261A
公开(公告)日：2014-02-14
申请号：KR1020130159707
申请日：2013-12-19
Applicant: 서울대학교산학협력단
Abstract: The present invention relates to tumor stem cell targeting peptide GICT which can selectively recognize and bind malignant undifferentiated brain tumor stem cells, and a diagnosis method of brain tumor using the peptide. The present invention provides a pharmaceutical composition for preventing and treating malignant tumor which contains the tumor stem cell targeting peptide denoted by sequence number 1 as an effective component.
Abstract translation: 本发明涉及可以选择性识别和结合恶性未分化脑肿瘤干细胞的肿瘤干细胞靶向肽GICT，以及使用该肽的脑肿瘤诊断方法。 本发明提供了含有以序列号1表示的肿瘤干细胞靶向肽作为有效成分的恶性肿瘤的预防和治疗药物组合物。
-
-
公开(公告)号：KR1020120124191A
公开(公告)日：2012-11-13
申请号：KR1020110041930
申请日：2011-05-03
Applicant: 서울대학교산학협력단
Inventor： 최윤재 , 조종수 , 강상기 , 모아매드아리풀이슬람
CPC classification number: A61K9/5073 , A61K9/0053 , A61K9/5031 , A61K9/5036 , A61K9/5089 , A61K47/34 , A61K47/36
Abstract: PURPOSE: A microcapsule for oral administration and a method for manufacturing the same are provided to improve mucosal adhesion and durability. CONSTITUTION: A microcapsule for oral administration contains 40-85 wt% of alginate, 5-20 wt% of poly-L-lysine, 5-20 wt% of alginate with a thiol group, and 5-20 wt% of physiologically active substance. The alginate is denoted by chemical formula 1. A method for preparing the alginate with the thiol group comprises: a step of adding L-cysteine salt to a reaction mixture; a step of adjusting pH of reacted mixture; and a step of performing dialysis of the reaction mixture. The average particle diameter of the microcapsule is 5-5000 um. A method for preparing the microcapsule comprises: a step of suspending the physiologically active substance in saline solution and adding alginate to the suspension; a step of reacting the reaction mixture in a calcium salt solution; a step of reacting the reaction mixture in a poly-L-lysine solution; and a step of coating the reaction mixture with the alginate solution containing thiol groups.
Abstract translation: 目的：提供用于口服的微胶囊及其制造方法，以改善粘膜粘附性和耐久性。 构成：用于口服给药的微胶囊包含40-85重量％的藻酸盐，5-20重量％的聚-L-赖氨酸，5-20重量％的具有硫醇基团的藻酸盐和5-20重量％的生理活性物质 。 藻酸盐由化学式1表示。用硫醇基制备藻酸盐的方法包括：向反应混合物中加入L-半胱氨酸盐的步骤; 调节反应混合物的pH的步骤; 以及进行反应混合物的透析的步骤。 微胶囊的平均粒径为5-5000μm。 制备微胶囊的方法包括：将生理活性物质悬浮在盐水溶液中并向悬浮液中加入藻酸盐的步骤; 使反应混合物在钙盐溶液中反应的步骤; 将反应混合物在聚-L-赖氨酸溶液中反应的步骤; 以及用含有硫醇基团的藻酸盐溶液涂覆反应混合物的步骤。
-
公开(公告)号：KR101132412B1
公开(公告)日：2012-04-03
申请号：KR1020090041161
申请日：2009-05-12
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A chitosan nanoaprticle immobilized with M cell targeting peptide and a carrier for transferring oral vaccine containing the same are provided to use as a novel carrier for transferring oral vaccine. CONSTITUTION: A method for chitosan nanoparticle immobilized with M cell targeting peptide comprises: a step of conjugating M cell targeting peptide to water soluble chitosan to obtain M cell targeting peptide-water soluble chitosan; a step of adding tripolyphosphate(TPP) solution to the peptide-water soluble chitosan solution containing Tween 80; a step of performing sonication; and a step of centrifuging solution. The M cell targeting peptide has CKSYHPLSC sequence of sequence number 1.
-
-
-
-
-
-
-
-
Search Results
49
records
(took 0.027 seconds)
