公开(公告)号：KR1020120125113A

公开(公告)日：2012-11-14

申请号：KR1020110043207

申请日：2011-05-06

Applicant: 충남대학교산학협력단

Inventor： 남명수 ,  송규용

IPC: C12N1/20 ,  A23L33/00 ,  A61K36/258 ,  C12R1/25

Abstract: PURPOSE: A novel Lactobacillus plantarum CRNB-22 strain with a saponin decomposition ability and a method for decomposing saponin using the same are provided to prepare ginseng and red ginseng fermentations. CONSTITUTION: A Lactobacillus plantarum CRNB-22(KCTC 11931 BP) strain has a saponin converting ability. The strain is used for converting saponin Rb1 into other ginsenoside. A method for preparing fermented ginseng comprises a step of inoculating ginseng with the strain and a step of fermenting at 20-50 Deg. C. for 20-120 hours. A health functional food contains the fermented ginseng. A pharmaceutical composition for preventing or treating inflammation, allergy, cancer, impotency, hypertension, hyperlipidemia, or aging contains the fermented ginseng.

Abstract translation: 目的：提供一种具有皂角苷分解能力的新型植物乳杆菌CRNB-22菌株和使用其分解皂苷的方法，以制备人参和红参发酵。 构成：植物乳酸乳杆菌CRNB-22（KCTC 11931 BP）菌株具有皂角苷转化能力。 该菌株用于将皂苷Rb1转化为其他人参皂甙。 制备发酵人参的方法包括用该菌株接种人参的步骤和在20-50度发酵的步骤。 C. 20-120小时。 保健功能食品含有发酵人参。 用于预防或治疗炎症，过敏，癌症，阳ency，高血压，高脂血症或衰老的药物组合物含有发酵人参。

公开(公告)号：KR101016996B1

公开(公告)日：2011-02-28

申请号：KR1020100051845

申请日：2010-06-01

Applicant: 충남대학교산학협력단

Inventor： 김영호 ,  송규용 ,  우선희

IPC: A61K36/258 ,  A61K31/56 ,  A61P9/00

CPC classification number: A61K36/258 ,  A23L33/105 ,  A61K31/575

Abstract: PURPOSE: A composition containing ginsenoside extracted from leaves, stems, or buds of ginseng plant is provided to reduce or enhance the contraction of heart chamber muscle and to treat cardiac insufficiency, myocardial infarction, and hypertension. CONSTITUTION: A composition for preventing or treating hypertension or angina pectoris contains ginsenoside F1 of chemical formula 1 or notoginsenoside R1 isolated from leaves, stems, or buds of ginseng plant. A health food for preventing or treating hypertension or angina pectoris contains ginsenosdie F1 or notoginsenoside R1. The health food is a dairy product including drinks, meats, sausage, bread, candy, snack, noodle, and ice cream and a supplementary product including beverage, alcoholic beverage, and vitamin. The used ginseng is Panax ginseng, Panax quinquefolia, Panax notoginseng, Panax japonicas, Panax vietnamensis, Panax elegatior, Panax wangianus, or Panax bipinratifidus.

Abstract translation: 目的：提取人参植物叶片，茎或芽提取人参皂苷的组合物，以减少或增强心室肌肉的收缩和治疗心功能不全，心肌梗死和高血压。 构成：用于预防或治疗高血压或心绞痛的组合物含有人参植物叶片，茎或芽分离的化学式1的人参皂苷F1或三七皂苷R1。 用于预防或治疗高血压或心绞痛的保健食品含有人参皂甙F1或三七皂苷R1。 保健食品是一种乳制品，包括饮料，肉类，香肠，面包，糖果，小吃，面条和冰淇淋以及补充产品，包括饮料，酒精饮料和维生素。 人参是人参，人参，三七，三七，三叉戟，Panax elegatior，Panax wangianus或Panax bipinratifidus。

公开(公告)号：KR100754253B1

公开(公告)日：2007-09-03

申请号：KR1020060044066

申请日：2006-05-17

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  신현중 ,  서영배 ,  이지현 ,  명창선 ,  오한진 ,  박용진

IPC: A23L1/212

CPC classification number: A61K36/258 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/2124 ,  A23V2200/308

Abstract: A novel process for manufacturing black ginseng with anti-cancer activity and a composition containing the same are provided to shorten manufacturing time and enable mass production by washing ginseng and repeating drying and steaming at proper temperature and time. A process for manufacturing black ginseng comprises the steps of: washing 5 year old green ginseng and firstly drying the washed ginseng at 35~55°C for 20~28hr; putting the dried ginseng in earthenware and firstly steaming at 85~105°C for 5~7hr; secondly drying the steamed ginseng at 50~70°C for 9~15hr; secondly steaming at 95~125°C for 5~7hr; and thirdly drying for 12hr. The dried black ginseng or extracts are pulverized to a particle of 50~200mum, and then can be prepared into the composition such as a pill, a capsule or a tablet.

Abstract translation: 提供一种制造具有抗癌活性的黑参的新方法和含有该组合物的组合物，以缩短制造时间，并且通过洗涤人参并在适当的温度和时间重复干燥和蒸汽来批量生产。 制造黑参的方法包括：洗涤5岁的青参，首先将洗涤的人参在35〜55℃下干燥20〜28小时; 将干参浸在陶器中，首先在85〜105℃下蒸5〜7小时; 其次在50〜70℃下干燥人参9〜15小时; 其次在95〜125℃下蒸5〜7小时; 第三次干燥12小时。 将干燥的黑参或提取物粉碎成50〜200μm的颗粒，然后可以制备成组合物，例如丸剂，胶囊或片剂。

公开(公告)号：KR102159276B1

公开(公告)日：2020-09-23

申请号：KR1020190004114

申请日：2019-01-11

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  김상겸 ,  최연정 ,  오유석

IPC: A61K31/37 ,  A61P9/00

公开(公告)号：KR101718351B1

公开(公告)日：2017-03-21

申请号：KR1020150091329

申请日：2015-06-26

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  남명수 ,  경기열 ,  조수현 ,  손지윤

IPC: C12N1/20 ,  A23L29/00 ,  A23L33/105 ,  A61K8/97 ,  A61K36/258

Abstract: 본발명은신규한패니바실러스속 RMKS 72 균주(sp. RMKS 72, 미생물수탁번호 KACC92078P), 이를이용한발효인삼, 및이 발효인삼의추출물을함유하는항산화활성을갖는조성물에관한것으로서, 상기패니바실러스속 RMKS 72 균주(sp. RMKS 72, 미생물수탁번호 KACC92078P)의배양액은인삼내의진세노사이드 Rb1을 Rd로변환시키는효과가우수하여, 상기균주를이용하여제조한발효인삼또는이의추출물은활성산소종에대한제거능이뛰어나, 항산화및 노화방지용화장료조성물, 건강기능식품, 또는약학조성물로유용하게사용될수 있다.

公开(公告)号：KR1020170001397A

公开(公告)日：2017-01-04

申请号：KR1020150091329

申请日：2015-06-26

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  남명수 ,  경기열 ,  조수현 ,  손지윤

IPC: C12N1/20 ,  A23L29/00 ,  A23L33/105 ,  A61K8/97 ,  A61K36/258

Abstract: 본발명은신규한패니바실러스속 RMKS 72 균주(sp. RMKS 72, 미생물수탁번호 KACC92078P), 이를이용한발효인삼, 및이 발효인삼의추출물을함유하는항산화활성을갖는조성물에관한것으로서, 상기패니바실러스속 RMKS 72 균주(sp. RMKS 72, 미생물수탁번호 KACC92078P)의배양액은인삼내의진세노사이드 Rb1을 Rd로변환시키는효과가우수하여, 상기균주를이용하여제조한발효인삼또는이의추출물은활성산소종에대한제거능이뛰어나, 항산화및 노화방지용화장료조성물, 건강기능식품, 또는약학조성물로유용하게사용될수 있다.

公开(公告)号：KR101625474B1

公开(公告)日：2016-05-31

申请号：KR1020140173837

申请日：2014-12-05

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  김지선 ,  허진혁 ,  안영광 ,  조수현 ,  이지현

IPC: C07J17/00 ,  C07H17/00

Abstract: 본발명은진세노사이드 Re의대량생산방법에관한것으로서, 자세하게는, 진세노사이드 Re에유기산을혼합하고고온고압처리를하여진세노사이드 Rh4를제조하는방법에관한것이다. 진세노사이드 Rh4는백삼에는존재하지않고홍삼이나흑삼에미량존재하는것으로서, 기존의인삼추출물이나홍삼추출물의가공을통해서는화학구조와분자량이유사한형태의진세노사이드들이다양하게존재하기때문에진세노사이드 Rh4의순수정제가쉽지않을뿐만아니라, 상기추출물내에는진세노사이드 Rh4 미량으로존재하기때문에정제된양이매우적다. 그러나, 본발명을통해서는인삼잎으로부터용이하게분리가능한진세노사이드 Re만을이용하여진세노사이드 Rh4를제조하기때문에, 추출물을이용할때와비교하여상대적으로진세노사이드 Rh4의정제가쉽고, 대량생산이아주용이하다. 또한표준정제된진세노사이드 Rh4의가격또한고가이기에, 본발명의진세노사이드 Re의대량생산방법을통해이와같은진세노사이드 Rh4의대량제조를통해고부가가치의창출이가능하다.

Abstract translation: 本发明涉及一种用于大量生产人参皂甙Re的方法，更具体地说，涉及一种大量生产人参皂甙-R Re的方法，其中有机酸与人参皂甙-Re混合，混合物在高温高压下处理 ，以产生人参皂甙Rh4。 人参皂甙Rh4少量存在，只有红参和黑参，而不是白参，常规手段通过人参提取物和红参提取物提取人参皂甙Rh4，不仅无法在人参皂苷中分离纯化人参皂甙 由于存在具有相似化学结构和分子量的各种其他人参皂甙，而且由于人参皂甙-Ro4在这种提取物中仅存在微量的量，所以分离和纯化的人参皂甙-Ro4的产率非常低。 另一方面，本发明仅通过使用能够容易地从人参叶分离的人参皂甙-R而生产人参皂甙-Ro4。 因此，与使用提取物相比，人参皂甙Rh4的分离纯化更容易，其大量生产容易。 此外，由于通过常规方法分离和纯化的人参皂苷-Rh4是昂贵的，因此本发明的批量生产人参皂甙-Ro4的方法能够廉价地生产人参皂甙-R4，可以产生更高的附加值。

公开(公告)号：KR101343434B1

公开(公告)日：2013-12-20

申请号：KR1020110043206

申请日：2011-05-06

Applicant: 충남대학교산학협력단

Inventor： 남명수 ,  송규용

IPC: C12N1/20 ,  A23L33/00 ,  A61K36/258

Abstract: 본발명은인삼및 홍삼의사포닌분해능을갖는신규한엔테로코커스패칼리스(Enterococcus faecalis) CRNB-A3 (KCTC 11930 BP) 균주및 이를이용한사포닌분해방법에대한것이다. 본발명에따른엔테로코커스패칼리스 CRNB-A3 (KCTC 11930 BP) 균주는인삼으로부터기존에알려지지않은새로운사포닌배당체를생성할수 있는능력을가지고있으므로, 상기균주를이용함으로써새로운효능을갖는인삼및 홍삼발효물을제조할수 있다.

公开(公告)号：KR101340335B1

公开(公告)日：2013-12-13

申请号：KR1020130048426

申请日：2013-04-30

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  전병화 ,  김영호

IPC: C07D311/30 ,  A61K31/352 ,  A61P9/00

Abstract: The present invention relates to a composition for preventing and treating vascular diseases containing flavone derivatives. The composition is capable of preventing and treating vascular diseases including arteriosclerosis, hypertension, angina, myocardial infarction, ischaemic heart diseases, cardiac insufficiency, complications caused after transluminal arterioplasty, cerebral infarction, cerebral hemorrhage, and stroke, and is capable of being used in the application to various kinds of medicines for improving vascular diseases. [Reference numerals] (AA,DD) Compound 1 (μM);(BB,FF) Compound 2 (μM);(CC,EE) Expression of VCAM-1 (%)

Abstract translation: 本发明涉及用于预防和治疗含有黄酮衍生物的血管疾病的组合物。 该组合物能够预防和治疗血管疾病，包括动脉硬化，高血压，心绞痛，心肌梗死，缺血性心脏病，心功能不全，经腔动脉成形术引起的并发症，脑梗塞，脑出血和中风，并且能够用于 适用于各种药物用于改善血管疾病。 化合物1（μM）;（BB，FF）化合物2（μM）;（CC，EE）VCAM-1（％）的表达

公开(公告)号：KR1020130104991A

公开(公告)日：2013-09-25

申请号：KR1020120027028

申请日：2012-03-16

Applicant: 부산대학교 산학협력단 ,  충남대학교산학협력단

Inventor： 박범준 ,  하남출 ,  송규용 ,  이지현 ,  이수진 ,  정연상

IPC: C07D493/04 ,  C07D311/06 ,  A61K31/352 ,  A61P35/00

Abstract: PURPOSE: A pharmaceutical composition for preventing or treating aging-related diseases and a method for screening a binding inhibitor are provided to effectively treat or prevent diseases caused by progerin and to specifically select a drug which suppresses binding between progerin and lamin A. CONSTITUTION: A compound of chemical formula 1 or 2 or a pharmaceutically acceptable salt thereof is provided. A pharmaceutical composition for preventing or treating aging-related diseases contains the compound of chemical formula 1 or 2 or a pharmaceutically acceptable salt thereof as an active ingredient. A method for screening a therapeutic agent for treating aging-related diseases comprises the step of selecting candidate drugs which suppress binding between progerin and lamin A.

Abstract translation: 目的：提供用于预防或治疗老化相关疾病的药物组合物和筛选结合抑制剂的方法，以有效治疗或预防由progerin引起的疾病，并具体选择抑制progerin和lamin A之间结合的药物。构成：A 提供化学式1或2的化合物或其药学上可接受的盐。 用于预防或治疗老化相关疾病的药物组合物含有化学式1或2的化合物或其药学上可接受的盐作为活性成分。 用于筛选治疗老化相关疾病的治疗剂的方法包括选择抑制脯氨酸和lamin lamin A之间结合的候选药物的步骤。