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公开(公告)号：KR1020120119786A
公开(公告)日：2012-10-31
申请号：KR1020110037976
申请日：2011-04-22
Applicant: 한국과학기술연구원
CPC classification number: A61F2/82 , A61F2250/0067 , A61F2310/00011 , A61F2310/0097 , A61L31/022 , A61L31/10 , A61L31/14 , A61L31/16
Abstract: PURPOSE: A phytoncide releasing stent is provided to more efficiently emit phytoncide in a living body. CONSTITUTION: A phytoncide releasing stent comprises a coating layer in which the mixture of phytoncide and biodegradable polymer is coated on the surface thereof. A stent is made of a metal material selected from stainless steel, cobalt-chrome, platinum-chrome, tantalum, titanium, nitinol, gold, platinum, silver, and their alloy. The biodegradable polymer is selected from a group consisting of polyglycolic acid, poly-L-lactic acid, poly-D-lactic acid, poly-D,L-lactic acid, poly-e-carprolactone, polylactic acid-glycolic acid copolymer, poly-L-lactic acid-e-caprolactone copolymer, polyethylene glycol, polyamino acid, polyanhydride, polyortho ester, polydioxanone, polyphosphazene, cellulose acetate butylate, cellulose triacetate, and their copolymer.
Abstract translation: 目的：提供一种放液剂释放支架，以更有效地在活体中释放出杀藻素。 构成：放液剂释放支架包括涂层，其中植物保护剂和可生物降解聚合物的混合物在其表面上被涂覆。 支架由选自不锈钢，钴铬，铂铬，钽，钛，镍钛诺，金，铂，银及其合金的金属材料制成。 生物降解性聚合物选自聚乙醇酸，聚-L-乳酸，聚-D-乳酸，聚-D，L-乳酸，聚己内酯，聚乳酸 - 乙醇酸共聚物，聚 -L-乳酸 - ε-己内酯共聚物，聚乙二醇，聚氨基酸，聚酐，聚缩醛酯，聚二恶烷酮，聚磷腈，乙酸纤维素丁酸酯，三乙酸纤维素及其共聚物。
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公开(公告)号：KR101107223B1
公开(公告)日：2012-01-25
申请号：KR1020090108221
申请日：2009-11-10
Applicant: 한국과학기술연구원
CPC classification number: B05D7/14 , A61L27/00 , A61L27/28 , A61L27/34 , A61L31/10 , A61L2400/12 , A61L2400/18 , B05D1/18 , B05D3/142 , Y10T428/273 , Y10T428/31678 , C08L67/04
Abstract: 본 발명은 금속 기판에 대한 고분자의 코팅 접착력과 생체 내에서의 상기 고분자의 안정성 및 내구성을 향상시키기 위하여, 금속 기판 표면에 고분자를 나노 커플링(nanocoupling)하는 기술에 관한 것이다. 본 발명에서는 나노 커플링에 의하여 고분자를 금속 기판의 표면에 화학적 결합으로 그라프트함으로써, 이후에 형성되는 고분자 코팅 층의 금속 기판에 대한 접착력과, 생체 내에서의 안정성 및 내구성을 현저하게 향상시킬 수 있다. 따라서 본 발명에 의한 나노 커플링 기술은 금속 기판, 예컨대, 스텐트, 기계식 판막, 관절, 척추, 뼈 및 치과 임플란트 등과 같은 금속 이식물의 표면 개질에 적용이 가능하다.
금속 기판, 금속 이식물, 생분해성 고분자, 나노 커플링, 표면 개질-
公开(公告)号：KR1020110118859A
公开(公告)日：2011-11-02
申请号：KR1020100038221
申请日：2010-04-26
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0075 , A61K9/1647 , A61K9/5036 , C12N2533/40
Abstract: PURPOSE: A method for preparing a delivery system for supporting physiologically active growth factors which are necessary for cell differentiation and proliferation is provided to maximize stem cell differentiation ability in vitro. CONSTITUTION: A growth factor delivery system comprises a core and shell structure containing two kinds of ingredients which are necessary for cell differentiation or proliferation. The delivery system is in the form of a microsphere of 100-400 um in dianeter. The delivery system is treated with a crosslinking agent of ethyl dimethyl amino propyl carbodiimide, genipin, or glutaraldehyde in the shell. A method for preparing the delivery system comprises: a step of preparing a polymeric microsphere containing a first ingredient needed for cell differentiation or proliferation; and a step of introducing the polymeric microsphere into other polymers containing a second ingredient needed for cell differentiation or proliferation.
Abstract translation: 目的：提供一种用于制备支持细胞分化和增殖所必需的生理活性生长因子的递送系统的方法，以使体外干细胞分化能力最大化。 构成：生长因子递送系统包括含有细胞分化或增殖所必需的两种成分的核心和壳结构。 递送系统为dianeter中100-400微米的微球形式。 递送系统在壳中用乙基二甲基氨基丙基碳二亚胺，天鹅蛋白或戊二醛的交联剂处理。 制备递送系统的方法包括：制备含有细胞分化或增殖所需的第一成分的聚合物微球的步骤; 以及将聚合物微球引入含有细胞分化或增殖所需的第二成分的其它聚合物的步骤。
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44.发明授权생분해성 및 생체친화성이 우수한 조직재생용 주입형 온도감응성 플루로닉 유도체 하이드로겔 및 이의 제조방법 有权具有高生物降解性和组织再生的生物活性的可注射的热致生物衍生水合物及其制备方法
公开(公告)号：KR101001855B1
公开(公告)日：2010-12-17
申请号：KR1020080103809
申请日：2008-10-22
Applicant: 한국과학기술연구원
IPC: C08G65/332 , C08G65/26 , C08J3/075
Abstract: 본 발명은 생분해성 및 생체친화성이 우수한 조직재생용 주입형 온도감응성 생분해 플루로닉(pluronic) 유도체 하이드로겔 및 이의 제조방법에 관한 것으로, 구체적으로 플루로닉 고분자의 한쪽 또는 양쪽 말단에 생분해성 고분자가 도입되고, 상기 생분해성 고분자에 메타크릴옥시에틸 트라이멜리트산(methacryloxyethyl trimellitic acid) 무수물이 결합되고, 상기 메타크릴옥시에틸 트라이멜리트산 무수물의 카르복실기에 생리활성물질이 중합된 구조를 갖는, 조직재생용 주입형 온도감응성 생분해 플루로닉 유도체 하이드로겔 및 이의 제조방법에 관한 것이다. 본 발명에 따른 플루로닉 유도체 하이드로겔은 플루로닉 고분자의 온도감응성(thermosentitive)은 그대로 유지하면서 생분해성 고분자의 도입으로 인해 생체 내에서 일정 기간 후에 분해되어 배설될 수 있는 생분해성(biodegradability)이 탁월하고, 세포증식성 또는 세포분화성을 향상시킬 수 있는 생리활성물질이 결합되어 있어 생체친화성(biocompatibility)이 우수하기 때문에, 인공조직이나 장기를 조직공학적으로 재생하는데 유용하게 사용될 수 있다.
조직재생, 하이드로겔, 플루로닉 유도체, 생분해성, 생체친화성, 생리활성물질-
公开(公告)号：KR1020090131975A
公开(公告)日：2009-12-30
申请号：KR1020080058006
申请日：2008-06-19
Applicant: 한국과학기술연구원
CPC classification number: A61K9/1647 , A61K9/1694 , A61K38/00
Abstract: PURPOSE: A method for preparing biodegradable covered porous polymer microspheres is provided to control a pore size of microspheres, and to prepare porous polymer microspheres capable of ensuring sustained release control and persistence of a sealed drug. CONSTITUTION: A method for preparing biodegradable covered porous polymer microspheres comprises the steps of: dissolving or suspending a bio-active material in a polymer solution that a biodegradable polymer is dissolved in an organic solvent to prepare a polymer solution containing a bio-active material; adding a hydrogen peroxide-containing compound to the polymer solution and mixing the mixture to prepare water-in-oil type emulsion; emulsifying the water-in-oil type emulsion in a emulsion stabilizer solution to prepare oil-in-water type emulsion; and adding a hydrogen peroxide decomposition catalyst to the oil-in-water type emulsion to degrade hydrogen peroxide and evaporate organic solvent.
Abstract translation: 目的：提供一种制备可生物降解的覆盖多孔聚合物微球的方法，以控制微球的孔径，并制备能够确保密封药物的持续释放控制和持久性的多孔聚合物微球。 构成：制备可生物降解的覆盖多孔聚合物微球的方法包括以下步骤：将生物活性物质溶解或悬浮在可生物降解聚合物溶于有机溶剂中的聚合物溶液中以制备含有生物活性物质的聚合物溶液; 向聚合物溶液中加入含过氧化氢的化合物，混合该混合物以制备油包水型乳液; 将油包水型乳液乳化在乳化稳定剂溶液中以制备水包油型乳液; 并向水包油型乳液中加入过氧化氢分解催化剂以降解过氧化氢并蒸发有机溶剂。
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Patent Agency Ranking
公开(公告)号：KR100786648B1
公开(公告)日：2007-12-21
申请号：KR1020060104859
申请日：2006-10-27
Applicant: 한국과학기술연구원
Abstract: A photopolymerizable composite material composition for dental service and orthopedics is provided to improve physical properties, mechanical properties and biocompatibility. A photopolymerizable composite material composition comprises 5-95 wt% of an organic matrix component; and 5-95 wt% of an inorganic filler. The organic matrix component comprises 15-80 wt% of a multifunctional methacrylate prepolymer selected from a bifunctional methacrylate prepolymer represented by the formula 2, a trifunctional methacrylate prepolymer represented by the formula 3, a tetrafunctional methacrylate prepolymer represented by the formula 4 and their mixture; 5-50 wt% of a diluent; 1-40 wt% of a polymerization monomer; 0.1-10 wt% of a photoinitiator; and 0.1-10 wt% of other additives, wherein n is a number of 0-2; and R is H, CH3, CH2CH3 or -C(CH3)3.
Abstract translation: 提供用于牙科服务和骨科的可光聚合复合材料组合物以改善物理性能，机械性能和生物相容性。 可光聚合复合材料组合物包含5-95重量％的有机基质组分; 和5-95重量％的无机填料。 有机基质组分包含15-80重量％的选自由式2表示的双官能甲基丙烯酸酯预聚物，由式3表示的三官能甲基丙烯酸酯预聚物，由式4表示的四官能甲基丙烯酸酯预聚物及其混合物的多官能甲基丙烯酸酯预聚物; 5-50重量％的稀释剂; 1-40重量％的聚合单体; 0.1-10重量％的光引发剂; 和0.1-10重量％的其它添加剂，其中n为0-2的数; 且R为H，CH 3，CH 2 CH 3或-C（CH 3）3。
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公开(公告)号：KR100760511B1
公开(公告)日：2007-10-04
申请号：KR1020060113167
申请日：2006-11-16
Applicant: 한국과학기술연구원
Abstract: A method for preparing a biodegradable porous polymer scaffold is provided to produce a biodegradable porous polymer scaffold for tissue engineering, which has no phenomena for pore clogging and harmful substances excretion and remain, and has an open structure with higher surface area and porosity. A method for preparing a biodegradable porous polymer scaffold for tissue engineering comprises the steps of: (a) adding a hydrogen peroxide-containing compound to a polymer solution which is obtained by dissolving a biodegradable polymer into a solvent, and mixing the resulting solution homogeneously; (b) allowing the solution obtained in the step (a) to stand at a temperature of -196 deg.C to a normal temperature so as to evaporate the solvent; and (c) introducing the polymer specimen obtained in the step (b) into an aqueous solution containing a catalyst for decomposition of hydrogen peroxide and foaming the resultant, followed by drying.
Abstract translation: 提供了一种制备可生物降解的多孔聚合物支架的方法，以生产组织工程的生物可降解多孔聚合物支架，其不存在孔堵塞和有害物质排泄现象，并具有较高表面积和孔隙率的开放结构。 制备用于组织工程的可生物降解的多孔聚合物支架的方法包括以下步骤：（a）向通过将可生物降解的聚合物溶解到溶剂中而获得的聚合物溶液中加入含过氧化氢的化合物，并均匀混合所得溶液; （b）使步骤（a）中得到的溶液在-196℃的温度下放置在常温下使溶剂蒸发; 和（c）将步骤（b）中获得的聚合物样品引入含有用于分解过氧化氢的催化剂的水溶液中并使所得物发泡，然后干燥。
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公开(公告)号：KR102159345B1
公开(公告)日：2020-09-23
申请号：KR1020190116892
申请日：2019-09-23
Applicant: 한국과학기술연구원
IPC: A61K35/33 , A61K35/28 , A61K35/34 , A61K35/407 , A61K9/06 , A61K31/7036 , A61K31/496
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公开(公告)号：KR20180002155A
公开(公告)日：2018-01-08
申请号：KR20160081254
申请日：2016-06-29
Applicant: 서울대학교산학협력단 , 한국과학기술연구원
Abstract: 본발명은유상성분; 계면활성제; 및수상성분을포함하고, 상기수상성분은수용성활성성분; 다당류; 및히알루론산을포함하는나노에멀전및 이의제조방법에관한것이다.
Abstract translation: 本发明的一个实施方案涉及纳米乳液及其制备方法，所述纳米乳液包含油性成分，表面活性剂和水性成分，其中所述水性成分包含水溶性活性成分，多糖和透明质酸。
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