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公开(公告)号：KR1020100107326A
公开(公告)日：2010-10-05
申请号：KR1020090025560
申请日：2009-03-25
Applicant: 한국과학기술연구원
IPC: C07D215/54 , C07D215/44
CPC classification number: C07D215/233 , A61K31/47 , C07D401/12 , C07D413/12
Abstract: PURPOSE: A novel aminoquinoline compound or pharmaceutically acceptable salt thereof are provided to ensure anti-proliferative efficiency with respect to melanoma and to prevent or treat skin cancer. CONSTITUTION: An amino quinoline compound is denoted by chemical formula 1. A method for preparing the amino quinoline compound or pharmaceutically acceptable salt thereof comprises: a step of performing nitration of a compound of chemical formula 2 to obtain a compound of chemical formula 3; a step of substituting the compound of chemical formula 3 to amino phenol compound to obtain a compound of chemical formula 4; a step of coupling the compound of chemical formula 4 with carboxylic acid compound of general formula R^5-CO_2H or isocyanate of general formula R^5-NCO to obtain a compound of chemical formula 5; a step of reducing the compound of chemical formula 5 to obtain a compound of chemical formula 6; a step of performing amidation of the compound of chemical formula 6 with carboxylic acid of general formula R^4-CO_2H. A pharmaceutical composition for preventing or treating skin cancer contains aminoquinoline compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 目的：提供一种新的氨基喹啉化合物或其药学上可接受的盐以确保相对于黑素瘤的抗增殖效能并预防或治疗皮肤癌。 构成：氨基喹啉化合物由化学式1表示。氨基喹啉化合物或其药学上可接受的盐的制备方法包括：对化学式2的化合物进行硝化以获得化学式3的化合物的步骤; 将化学式3的化合物代替氨基酚化合物以获得化学式4的化合物的步骤; 将化学式4的化合物与通式为R 5，-CO 2 H的羧酸化合物或通式为R 5，NCO的异氰酸酯偶联，得到化学式5化合物的步骤; 还原化学式5的化合物以获得化学式6的化合物的步骤; 用通式为R 4 -OR-CO 2 H的羧酸进行化学式6的化合物的酰胺化反应的步骤。 用于预防或治疗皮肤癌的药物组合物含有化学式1的氨基喹啉化合物或其药学上可接受的盐作为活性成分。
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公开(公告)号：KR1020080061903A
公开(公告)日：2008-07-03
申请号：KR1020060137092
申请日：2006-12-28
Applicant: 한국과학기술연구원
IPC: C07D477/20
Abstract: 1beta-Methyl carbapenem derivatives are provided to show strong antibacterial activity against bacteria having resistance against the conventional carbapenem compounds by introducing pyrrolidine derivatives with sulfamoyl moieties, so that the compounds are useful as antibiotics. The 1beta-methyl carbapenem derivatives represented by the formula(I) show strong antibiotic activity, wherein R is hydrogen, acetyl, carbamoyl or low alkyl-substituted sulfamoyl moieties, and is prepared by substituting by pyrrolidine thiol derivatives represented by the formula(II) containing alpha-methoxyimine, beta-sulfamoyl and carbamoyl group at the C-2 site, wherein R is methyl sulfonyl, ethane sulfonyl, methane amino sulfonyl, dimethyl sulfonyl, acetyl, amino sulfonyl or amino carbamoyl.
Abstract translation: 提供了1,1-甲基碳青霉烯衍生物，以通过引入吡咯烷衍生物与氨磺酰部分来显示出对常规碳青霉烯类化合物具有抗性的细菌的强抗菌活性，使得该化合物可用作抗生素。 由式（I）表示的1β-甲基碳代青霉烯衍生物显示出强的抗生素活性，其中R为氢，乙酰基，氨基甲酰基或低级烷基取代的氨磺酰部分，并且通过用式（II）表示的吡咯烷硫醇衍生物代替， 其中R是甲基磺酰基，乙磺酰基，甲氨基磺酰基，二甲基磺酰基，乙酰基，氨基磺酰基或氨基氨基甲酰基，在C-2位上含有α-甲氧基亚胺，β-氨磺酰基和氨基甲酰基。
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公开(公告)号：KR100681482B1
公开(公告)日：2007-04-16
申请号：KR1020050102609
申请日：2005-10-28
Applicant: 한국과학기술연구원
IPC: A61K31/7048 , A61K36/00
Abstract: 본 발명은 천수근으로부터 추출한 하르파고시드 엑기스를 유기 염기로 가수분해하여 하르파지드를 생성시킨 후, 강염기성 음이온 교환수지 컬럼 크로마토그래피, 실리카겔 컬럼 크로마토그래피 및 활성탄 컬럼 크로마토그래피로 순차적으로 정제하는 것을 포함하는, 천수근으로부터 하르파지드를 간단하면서도 경제적으로 분리하는 방법에 관한 것이다.
하르파지드, 강염기성 음이온 교환수지 크로마토그래피, 활성탄 컬럼 크로마토그래피.Abstract translation: 本发明包括纯化的顺序的Har，从cheonsugeun提取到随后与有机碱水解，生成哈尔波叠氮化物，强碱性阴离子交换树脂柱层析，硅胶柱色谱法今后籽提取物和活性炭柱色谱法 从经济角度来看，
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公开(公告)号：KR1020030021343A
公开(公告)日：2003-03-15
申请号：KR1020010054467
申请日：2001-09-05
Applicant: 한국과학기술연구원
IPC: C07D487/02
Abstract: PURPOSE: Antibacterial carbapenem derivatives which are active against resistant strains are provided. They are pyrrolidine thiol carbapenems represented by formula(1), wherein R1 is hydrogen, substituted or unsubstituted lower alkly, heterocycles containing N or S, sulfonyl substituted with lower alkyl, carbonyl substituted with heterocycles containing N or S, benzyl, amide or hydroxy group; R2 is hydrogen, hydroxy alkyl, amide or ester group. CONSTITUTION: The method of preparation comprises: reacting phosphate compound with thiol derivatives represented by formula(2) under base and obtaining protected carbapenem derivatives; de-protecting them using hydrogen and palladium as a catalyst; and purifying with porous resin and freeze drying. In formula (2), R1 and R2 are same as in formula(1) and PNZ is p-nitrobenzyloxycarbonyl group.
Abstract translation: 目的：提供对抗性菌株有活性的抗菌碳青霉烯衍生物。 它们是由式（1）表示的吡咯烷硫醇碳青霉烯，其中R 1是氢，取代或未取代的低级烷基，含有N或S的杂环，被低级烷基取代的磺酰基，被含有N或S的杂环取代的羰基，苄基，酰胺或羟基 ; R2是氢，羟烷基，酰胺或酯基。 构成：制备方法包括：使磷酸酯化合物与式（2）表示的硫醇衍生物反应，并得到被保护的碳青霉烯衍生物; 使用氢和钯作为催化剂去保护它们; 并用多孔树脂进行纯化并冷冻干燥。 式（2）中，R 1和R 2与式（1）相同，PNZ为对硝基苄氧基羰基。
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公开(公告)号：KR100367575B1
公开(公告)日：2003-01-10
申请号：KR1020000041597
申请日：2000-07-20
Applicant: 한국과학기술연구원
IPC: A01G31/00
Abstract: 콩나물류의 부패가 일어나지 않아 위생적이고 생산성이 높음과 아울러 폐수에 의한 환경오염문제가 없는 콩나물류 재배방법 및 그 장치에 관한 것으로, 콩나물 재배부로부터 배출된 오염물질 내지 불순물이 포함된 재배수에 응집제를 투입하여 오염물질 내지 불순물을 응집시켜 슬러지가 되게 하는 단계와, 응집된 슬러지를 포함한 재배수를 DAF처리하여 슬러지를 제거하는 단계와, 슬러지가 제거된 깨끗한 재배수를 상기 콩나물 재배부로 재공급하는 단계를 구비하는 것을 특징으로 하는 콩나물류 재배방법과 그를 실현하기 위한 장치가 제공된다.
Abstract translation: 目的：提供一种豆芽的培育方法和装置，该方法和装置能够防止豆芽在处理后通过循环用水而防止豆腐腐烂，该方法和装置可防止环境污染，提高生产率并减少用水量。 组成：在含有从豆芽培养部分（1）排出的污染物或杂质的废水中，在溶解气浮（DAF）罐（3）中引入混凝剂以凝结污染物或杂质，从污泥 - 通过DAF处理废水和处理后的含水废水，用消毒剂对废水进行灭菌并向其中倒入无机营养素后，再将其供给豆芽的培养部分。 凝固剂和防腐剂的浓度分别为1至20ppm和0.1至10ppm。
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Patent Agency Ranking
公开(公告)号：KR1020020087570A
公开(公告)日：2002-11-23
申请号：KR1020010026194
申请日：2001-05-14
Applicant: 한국과학기술연구원 , 주식회사 엔에스케이텍
IPC: A61K36/068 , A61P3/10
Abstract: PURPOSE: A method for cultivation of Paecilomyces Japonica using a silkworm without a pupa as a host and a freeze drying method is provided. Therefore, a product having an excellent therapeutic effect on diabetic is produced with high productivity without causing the depletion of nutrients. CONSTITUTION: In the process for artificial cultivation of Paecilomyces Japonica, a 5 day old silkworm as a host is subjected to sterilization using chlorine dioxide water with a concentration of 1 to 5ppm without using heat treatment, a compound selected from the group consisting of silk amino acid, sugar and a mixture thereof is added to a medium for cultivation thereof, and then the silkworm is freeze dried and killed through an electric shock method.
Abstract translation: 目的：提供使用没有蛹作为宿主的蚕培养拟青藓的方法和冷冻干燥方法。 因此，以高生产率生产对糖尿病具有优异治疗效果的产品，而不会导致营养物质的消耗。 构成：在人造培养拟青藓的过程中，将5日龄的蚕作为宿主，使用浓度为1〜5ppm的二氧化氯水进行灭菌，不用热处理，选自丝氨基 酸，糖及其混合物加入到培养基中，然后通过电击法将蚕冷冻干燥灭活。
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公开(公告)号：KR1020020005863A
公开(公告)日：2002-01-18
申请号：KR1020000039341
申请日：2000-07-10
Applicant: 한국과학기술연구원
IPC: C01B11/02
CPC classification number: C01B11/024 , B01J19/006 , B01J19/1893 , B01J2219/00164 , B01J2219/00177 , B01J2219/00763
Abstract: PURPOSE: A method for preparing chlorine dioxide in high yield is accomplished by proper adjustment of the supply ratio of sodium chlorite and chlorine, by which hydrogen-ion concentration condition is optimized. The chlorine dioxide, when applied to cooling water, showed excellent bactericidal effect against Legionella pneumophila when applied to cooling water. In addition, chlorine dioxide has proven to be effective in eliminating alien algae in cultivating lava. CONSTITUTION: In the generation of chlorine dioxide using sodium chlorite and chlorine, by using a flowmeter and a chemical pump, Cl2 supply rate and NaClO2 supply rate are controlled to adjust pH in the range 1.9 to 2.0. For the smooth dissolving of chlorine gas into sodium chlorite solution, chlorine gas is supplied through glass wool(7), and a baffle(8) is installed to be perpendicular to a sodium chlorite/chlorine inlet. The baffle plays role in converting laminar flow to turbulent flow within short time.
Abstract translation: 目的：通过适当调整亚氯酸钠和氯的供应比，通过优化氢离子浓度条件来实现高产量制备二氧化氯的方法。 当应用于冷却水时，二氧化氯在用于冷却水时对嗜肺军团病菌显示出极好的杀菌作用。 此外，二氧化氯已被证明有效地消除培养熔岩中的外来藻类。 构成：使用亚氯酸钠和氯生成二氧化氯，通过使用流量计和化学泵，控制Cl2供应速率和NaClO2供应速率，调节pH在1.9至2.0。 为了将氯气平滑溶解在亚氯酸钠溶液中，氯气通过玻璃棉（7）供应，挡板（8）安装成与亚氯酸钠/氯气入口垂直。 挡板在短时间内将层流转化为湍流的作用。
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公开(公告)号：KR1020000051067A
公开(公告)日：2000-08-16
申请号：KR1019990001305
申请日：1999-01-18
Applicant: 한국과학기술연구원
IPC: C07D473/00
Abstract: PURPOSE: A purine compound having a substitutent group at the C-8 position is provided which is expected to be useful as an inhibitor of cyclin-dependent kinase. CONSTITUTION: A purine compound represented by the formula 1 having a substitutent group at the C-8 position is prepared, Thus, urea and ethylisocyanoacetate are subjected to heating reflux in the presence of a base to give a compound of formula 2, which is subjected to heating reflux after nitration and treated with sodium hydrosulfide to give a compound of formula 3, which is subjected to reaction continuously to give the title compound. In formula, R1 is methyl or phenyl; R2 is ethanolamine, or 2-amino-3-methyl-1-butanol.
Abstract translation: 目的：提供在C-8位置具有取代基的嘌呤化合物，其预期可用作细胞周期蛋白依赖性激酶的抑制剂。 构成：制备在C-8位具有取代基的式1表示的嘌呤化合物。因此，在碱的存在下，将脲和乙基异氰酸乙酯进行加热回流，得到式2的化合物， 硝化后加热回流并用氢硫化钠处理，得到式3的化合物，其连续进行反应，得到标题化合物。 在式中，R 1是甲基或苯基; R2是乙醇胺，或2-氨基-3-甲基-1-丁醇。
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公开(公告)号：KR1020000051061A
公开(公告)日：2000-08-16
申请号：KR1019990001299
申请日：1999-01-18
Applicant: 한국과학기술연구원
IPC: C07D477/00 , C07D487/04
Abstract: PURPOSE: A thiol derivative having a novel bicyclic and 1-beta-methyl-carbaphenem having them as a substituent group at its 2-position are provided which are useful for resolving the reduction of activity of conventional carbaphenem by DHP-1. CONSTITUTION: A bicyclic thiol derivative of formula (1) and 1-beta-methyl-2-thio based carbaphenem of formula (2) having two methyl groups at its 2-position are described. In formula, R denotes H, C1-6 lower alkyl, C1-6 lower cycloalkyl, aryl, benzyl, or amino group-substituted C1-6 lower alkyl. Preferably the lower alkyl is methyl, ethyl, propyl, cyclopropylmethyl and the amino group-substituted C1-6 lower alkyl is amino ethyl.
Abstract translation: 目的：提供一种具有新的双环和1-β-甲基 - 碳青霉烯在其2-位具有取代基的硫醇衍生物，可用于解决通过DHP-1降低常规碳青霉烯酮的活性。 描述：描述了在其2位具有两个甲基的式（1）的双环硫醇衍生物和式（2）的1-β-甲基-2-硫基碳代苯并芬酮。 在式中，R表示H，C 1-6低级烷基，C 1-6低级环烷基，芳基，苄基或氨基取代的C 1-6低级烷基。 优选地，低级烷基是甲基，乙基，丙基，环丙基甲基，氨基取代的C 1-6低级烷基是氨基乙基。
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