公开(公告)号：US20050110992A1

公开(公告)日：2005-05-26

申请号：US10794071

申请日：2004-03-05

Applicant: Axel Scherer ,  Marko Loncar

Inventor： Axel Scherer ,  Marko Loncar

IPC: G01J3/30 ,  G01N21/39 ,  G01N21/41 ,  G01N21/77 ,  G02B6/122 ,  H01S20060101 ,  H01S5/04 ,  H01S5/10

CPC classification number: B82Y20/00 ,  G01N21/41 ,  G01N2021/391 ,  G01N2021/7776 ,  G02B6/1225 ,  H01S5/041 ,  H01S5/10 ,  H01S5/105

Abstract: A system, method and apparatus provide the ability to detect a chemical in an analyte. To detect the chemical, the invention utilizes a laser having an open cavity. A photonic crystal lattice structure having a defect defines a suitable geometry for such a cavity. The analyte is introduced directly into a high optical field of the cavity. Thereafter, the cavity is pumped and an emission from the laser is used to detect the presence of the chemical in the analyte.

Abstract translation: 系统，方法和装置提供检测分析物中化学物质的能力。 为了检测化学品，本发明利用具有开口腔的激光器。 具有缺陷的光子晶格结构限定了这种空腔的合适几何形状。 将分析物直接引入空腔的高光场。 此后，泵入空腔，并使用来自激光器的发射来检测分析物中化学物质的存在。

公开(公告)号：US06828786B2

公开(公告)日：2004-12-07

申请号：US10346811

申请日：2003-01-17

Applicant: Axel Scherer ,  Mladen Barbic

Inventor： Axel Scherer ,  Mladen Barbic

IPC: G01V300

CPC classification number: G01R33/5604 ,  B82Y15/00 ,  G01R33/285

Abstract: The invention combines (A) capabilities in fabrication, characterization, and manipulation of single domain magnetic nanostructures, with (B) the use of binding chemistry of biological molecules to modify the magnetic nanostructures into magnetic sensors and magnetically controllable nanoprobes. A biological characterization scheme is realized by combining nanomanipulation and observation of small magnetic structures in fluids. By coating nanomagnets with biological molecules, ultra-small, highly sensitive and robust biomagnetic devices are defined, and molecular electronics and spin electronics are combined. When these nano-sensors are integrated into microfluidic channels, highly efficient single-molecule detection chips for rapid diagnosis and analysis of biological agents are constructed.

Abstract translation: 本发明结合了（A）制造，表征和操纵单畴磁性纳米结构的能力，（B）使用生物分子的结合化学将磁性纳米结构改性为磁性传感器和磁性可控的纳米探针。 通过组合纳米操作和观察流体中的小磁性结构来实现生物表征方案。 通过用生物分子涂覆纳米磁体，定义了超小型，高灵敏度和鲁棒的生物磁性器件，并结合了分子电子学和自旋电子学。 当这些纳米传感器集成到微流体通道中时，构建了用于快速诊断和分析生物制剂的高效单分子检测芯片。

公开(公告)号：US06627469B2

公开(公告)日：2003-09-30

申请号：US09832413

申请日：2001-04-10

Applicant: John O'Brien ,  Chuan-cheng Cheng ,  Axel Scherer ,  Amnon Yariv ,  Yong Xu

Inventor： John O'Brien ,  Chuan-cheng Cheng ,  Axel Scherer ,  Amnon Yariv ,  Yong Xu

IPC: H01L2100

CPC classification number: H01L33/20

Abstract: A lens is formed out of semiconductor material. The semiconductor produces light which is coupled to the lens. The lens focuses the light and also minimizes refractive reflection. The lens is formed by a graded aluminum alloy, which is oxidized in a lateral direction. The oxidation changes the effective shape of the device according to the grading.

Abstract translation: 透镜由半导体材料形成。 半导体产生耦合到透镜的光。 镜头对光线进行聚焦，并且还可以减少折射反射。 透镜由横向氧化的渐变铝合金形成。 氧化根据分级改变装置的有效形状。

公开(公告)号：US06593065B2

公开(公告)日：2003-07-15

申请号：US09803840

申请日：2001-03-12

Applicant: Axel Scherer

Inventor： Axel Scherer

IPC: G03F726

CPC classification number: B82Y10/00 ,  B81C1/00404 ,  B81C2201/0132 ,  G03F7/16 ,  Y10S977/72 ,  Y10S977/742 ,  Y10S977/887

Abstract: The invention is directed to a method of fabricating sub-wavelength features in semiconductors and insulators by starting with optical lithography patterns defined in a resist and then employing shadow-evaporation and directional etching to define nano-scale features. The directionality of this process is used together with a carefully defined photoresist mask to define an ion etching mask which allows the formation of very narrow trenches adjacent to the photoresist regions. Such narrow trenches can be used for electrical device isolation, for the definition of very small flow channels, and for the deposition of very narrow electrical contacts and wires.

公开(公告)号：US06515292B1

公开(公告)日：2003-02-04

申请号：US09315118

申请日：1999-05-19

Applicant: Axel Scherer ,  Elena Vuckovic

Inventor： Axel Scherer ,  Elena Vuckovic

IPC: G21K510

CPC classification number: G03F7/70375 ,  B82Y10/00 ,  B82Y40/00 ,  H01J37/3175 ,  H01J2237/31779

Abstract: A photocathode electron projector is formed with a sample attached to an anode and a patterned quartz mask attached to a cathode. The quartz mask is patterned with Au—Pd layers that emit electrons when illuminated by ultraviolet light. The ultraviolet light is filtered to just above the work function of the Au—Pd material. This has the effect of causing substantially monochromatic electrons to be emitted. The electrons are brought under influence of a parallel electric and magnetic field to thereby undergo a cyclotronic orbit. An integer number of cyclotronic orbits insures that the electrons hit the sample substantially at the same location as they were on mask.

Abstract translation: 形成具有附接到阳极的样品和附着到阴极的图案化石英掩模的光电阴极电子投影仪。 用由紫外线照射时发射电子的Au-Pd层构图石英掩膜。 紫外光被过滤到刚刚高于Au-Pd材料的功函数。 这具有使基本单色电子发射的效果。 电子受到并联电场和磁场的影响，从而经历循环轨道。 一整数的循环轨道确保电子基本上与掩模上相同的位置撞击样品。

公开(公告)号：US09233369B2

公开(公告)日：2016-01-12

申请号：US13336717

申请日：2011-12-23

Applicant: Imran R. Malik ,  Axel Scherer

Inventor： Imran R. Malik ,  Axel Scherer

IPC: B29C65/00 ,  B32B37/00 ,  B32B38/04 ,  B08B7/00 ,  B08B9/02 ,  E03B1/00 ,  F17D3/00 ,  F03B11/02 ,  F15B13/00 ,  F16L3/01 ,  F15C1/06 ,  B01L3/00 ,  B01L7/00 ,  B29C65/48 ,  B32B3/02 ,  B32B3/30

CPC classification number: B01L3/502707 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/16 ,  B29C65/486 ,  B32B3/02 ,  B32B3/30 ,  Y10T137/8593

Abstract: A method of fabricating a fluidic device comprises providing a fluidic device including a body having a surface and one or more channels located in the body. Recesses are defined on said surface. The one or more channels can have respective boundaries. A layer of adhesive including one or more panel-shaped pieces having a pattern based on the pattern of boundaries of the channels can be formed and applied on the surface of the body. It is further controlled that the layer of adhesive has respective boundaries surrounding the boundaries of the one or more channels.

Abstract translation: 制造流体装置的方法包括提供流体装置，其包括具有表面的主体和位于主体中的一个或多个通道。 凹槽被定义在所述表面上。 一个或多个通道可以具有相应的边界。 可以形成包括一个或多个基于通道边界图案的图案的一个或多个面板形件的粘合剂层，并施加到主体的表面上。 进一步控制粘合剂层具有围绕一个或多个通道的边界的相应边界。

公开(公告)号：US09057568B2

公开(公告)日：2015-06-16

申请号：US12638829

申请日：2009-12-15

Applicant: Imran R. Malik ,  Axel Scherer

Inventor： Imran R. Malik ,  Axel Scherer

IPC: F28F13/00 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/68 ,  G01N21/64 ,  F28D21/00

CPC classification number: B01L7/52 ,  B01L3/5027 ,  B01L3/502715 ,  B01L7/5255 ,  B01L2200/147 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1883 ,  C12Q1/6851 ,  F28D2021/0077 ,  F28F13/00 ,  F28F2013/008 ,  G01N21/6428 ,  C12Q2565/629 ,  C12Q2561/113 ,  C12Q2527/101

Abstract: Temperature control devices and methods are described. The described temperature control devices and methods comprise optical emission and detection assemblies and can be used in PCR and qPCR applications.

Abstract translation: 描述温度控制装置和方法。 所描述的温度控制装置和方法包括光发射和检测组件，并且可以用于PCR和qPCR应用中。

公开(公告)号：US09005548B2

公开(公告)日：2015-04-14

申请号：US12712097

申请日：2010-02-24

Applicant: Michael D. Henry ,  Andrew P. Homyk ,  Axel Scherer ,  Thomas A. Tombrello ,  Sameer Walavalkar

Inventor： Michael D. Henry ,  Andrew P. Homyk ,  Axel Scherer ,  Thomas A. Tombrello ,  Sameer Walavalkar

IPC: B01L3/00 ,  H01L21/308 ,  B81C1/00 ,  H01L21/3065

CPC classification number: B81C1/00111 ,  B01J19/0046 ,  B01J2219/00504 ,  B01J2219/00664 ,  B81B1/006 ,  B81B2203/0361 ,  B81B2207/056 ,  B81C2201/0112 ,  B81C2201/0132 ,  B81C2201/0133 ,  B81C2201/0159 ,  G01N1/405 ,  H01L21/3065 ,  H01L21/30655 ,  H01L21/3081 ,  H01L21/3086 ,  Y10T436/25375

Abstract: Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.

Abstract translation: 描述了制造高纵横比探针和变形微柱和纳米柱的方法。 还描述了聚合物在变形纳米柱和微柱体中的使用。

公开(公告)号：US08695640B2

公开(公告)日：2014-04-15

申请号：US13360261

申请日：2012-01-27

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: F15C1/06

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

Abstract translation: 一种制造弹性体结构的方法，包括：在第一微加工模具的顶部上形成第一弹性体层，所述第一微加工模具具有形成沿所述第一弹性体层的底表面延伸的第一凹槽的第一凸起突起; 在第二微加工模具的顶部上形成第二弹性体层，所述第二微加工模具具有第二凸起突起，所述第二凸起突起形成沿所述第二弹性体层的底表面延伸的第二凹槽; 将第二弹性体层的底表面粘合到第一弹性体层的顶表面上，使得控制通道在第一和第二弹性体层之间的第二凹部中形成; 以及将第一弹性体层定位在平面基底的顶部上，使得流动通道在第一弹性体层和平面基底之间的第一凹部中形成。

公开(公告)号：US08695355B2

公开(公告)日：2014-04-15

申请号：US11297106

申请日：2005-12-07

Applicant: George Maltezos ,  Matthew Johnston ,  Axel Scherer

Inventor： George Maltezos ,  Matthew Johnston ,  Axel Scherer

IPC: B01L3/00 ,  F25B21/02 ,  F25B21/04

CPC classification number: B01L3/5027 ,  F25B21/02 ,  F25B21/04 ,  H01L35/30

Abstract: A heating/cooling device for a microfluidic apparatus having a thermal insulating substrate. The device includes heating/cooling chamber for heating and/or cooling a sample disposed in the chamber; a waste heat channel for carrying away waste heat and/or waste cooling; and at least one Peltier junction having first and second opposing faces, the first face thereof facing towards said heating/cooling chamber and being in thermal communication therewith for providing either heat or cooling to the chamber in response to a flow of electrical current through the at least one Peltier junction, the second face thereof facing towards said waste heat channel and being in thermal communication therewith for either receiving heat from or dumping heat to the channel in response to a flow of electrical current through the Peltier junction.

Abstract translation: 一种用于具有绝热基底的微流体装置的加热/冷却装置。 该装置包括用于加热和/或冷却设置在腔室中的样品的加热/冷却室; 用于浪费废热和/或废物冷却的废热通道; 以及至少一个珀尔帖接头，其具有第一和第二相对面，其第一面朝向所述加热/冷却室并与其热连通，用于响应于电流通过所述的电流而向所述室提供加热或冷却 至少一个珀耳帖接头，其第二面朝向所述废热通道并与其热连通，以响应于通过珀尔帖接头的电流流动来接收热量或将热量倾倒至通道。