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公开(公告)号：AU2004215238A1
公开(公告)日：2004-09-10
申请号：AU2004215238
申请日：2004-02-24
Applicant: BASF AG
Inventor： ZELINSKI THOMAS , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS
Abstract: The present Invention relates to new nitrilases with modified Substrate acceptance, the method to obtain them and the use of the aforesaid nitrilases. Said nitrilases are encoded by a polypeptide sequence, which at a Position corresponding to Position 296 in wild-type Alcaligenes faecalis comprises an amino acid which is not tyrosine. The Invention further relates to nucleic acid sequences and amino acid sequences encoding Said nitrilases, expression constructs comprising Said nucleic acid sequences, vectors comprising the nucleic acid sequences or the exPression constructs, to organisms, preferably microorganisms, comprising the nucleic acid sequences, expression constructs or vectors. The Invention additionally relates to a method for preparing carboxylic acids, preferably substituted chiral carboxylic acids from racemic nitriles.
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公开(公告)号：EE200200225A
公开(公告)日：2003-06-16
申请号：EEP200200225
申请日：2000-10-20
Applicant: BASF AG
Inventor： KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , MATTES RALF
Abstract: The present invention relates to proteins which have an enzymatic activity for hydrolyzing L-pantolactone. The invention further relates to nucleic acids which code for these proteins, to nucleic acid constructs, vectors, genetically modified microorganisms and to a process for preparing D-pantolactone.
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公开(公告)号：NO20031213L
公开(公告)日：2003-05-13
申请号：NO20031213
申请日：2003-03-17
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS
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公开(公告)号：NO20031213A
公开(公告)日：2003-05-13
申请号：NO20031213
申请日：2003-03-17
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS
CPC classification number: C12P9/00
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公开(公告)号：HU0203704A2
公开(公告)日：2003-03-28
申请号：HU0203704
申请日：2000-10-20
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS , HAUER BERHARD , KESSELER MARIA , MATTES RALF
Abstract: The present invention relates to proteins which have an enzymatic activity for hydrolyzing L-pantolactone. The invention further relates to nucleic acids which code for these proteins, to nucleic acid constructs, vectors, genetically modified microorganisms and to a process for preparing D-pantolactone.
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Patent Agency Ranking
公开(公告)号：AU2002328843A1
公开(公告)日：2003-03-03
申请号：AU2002328843
申请日：2002-07-05
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS , EICHLER KNUT , BECK CHRISTINE
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公开(公告)号：AU2002304725A1
公开(公告)日：2002-11-05
申请号：AU2002304725
申请日：2002-04-08
Applicant: BASF AG
Inventor： STURMER RAINER , FRIEDRICH THOMAS , ZIMMERMANN NORBERT
IPC: C07D211/20 , C07D265/30 , C07D279/12 , C12N9/06 , C12P7/04 , C12P7/18 , C12P7/22 , C12P13/00 , C12P13/24 , C12P17/10 , C12P17/12 , C12P17/14
Abstract: The invention relates to methods for reacting (di)amines as substrates in the presence of a lysine oxidase arid a reducing agent, resulting in alcohols, diols or cyclic secondary amines. In a particular embodiment, the invention is directed to methods of preparing cyclic secondary amines suitable for ultimately synthesizing piperidine-2-carboxylic acid and proline derivatives, useful, for example as thrombin inhibitors.
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公开(公告)号：HU0104802A2
公开(公告)日：2002-04-29
申请号：HU0104802
申请日：1999-10-13
Applicant: BASF AG
Inventor： ENGELS DIRK , FRIEDRICH THOMAS , HAUER BERHARD , MATTES RALF , RESS-LOESCHKE MARION
IPC: C07H21/00 , C12N15/09 , C12N1/21 , C12N9/78 , C12N15/55 , C12P7/40 , C12P7/42 , C12P41/00 , C12R1/05
Abstract: The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention further relates to amino acid sequences which are encoded by the nucleic acid sequences, and to microorganisms comprising the nucleic acid sequences, the nucleic acid constructs or vectors comprising the nucleic acid sequences or the nucleic acid constructs.The invention additionally relates to a process for preparing chiral carboxylic acids from the racemic nitriles.
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公开(公告)号：DE10046039A1
公开(公告)日：2002-03-28
申请号：DE10046039
申请日：2000-09-18
Applicant: BASF AG
Inventor： FRIEDRICH THOMAS
Abstract: The invention relates to a method for the polycondensation of organic silicon compounds at pH values between 6 and 8 in the presence of a lipase, said lipase being optionally immobilised on a carrier consisting of polymer materials. Suitable polycondensable organic silicon compounds are (RO)(R O)(R O)(R O)Si, (RO)(R O)(R O)(R O)SiR , (RO)(R O)Si(R )(R ) and (RO)SiR R R with R, R , R and R independently representing C1- to C10-alkyl, C3- to C10-cycloalkyl, C4- to C20-alkylcycloalkyl, aryl, C6- to C16-alkylaryl, the alkyl groups being linear or branched. It is advantageous that the lipase can be obtained relatively easily by means of large-scale fermentation processes. Lipases from Pseudomona species are preferable.
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公开(公告)号：DE10029194A1
公开(公告)日：2001-12-20
申请号：DE10029194
申请日：2000-06-19
Applicant: BASF AG
Inventor： KESELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , MATTES RALF
Abstract: Isolated nucleic acid (I) that encodes a polypeptide (II) with L-pantolactone hydrolase activity is (i) a 810 bp sequence (1); (ii) equivalents of (i) within the degeneracy of the genetic code; (iii) derivatives of (1) that encode a polypeptide at least 50% homologous with a 269 amino acid protein (2) and having essentially the same enzymatic activity; and (iv) functional equivalents of (i)-(iii). Independent claims are also included for the following: (a) protein (IIa) encoded by (I); (b) nucleic acid construct (A) containing (A) linked to at least one regulatory sequence; (c) vector containing (I) or (A); (d) microorganisms containing (I), (A) or the vector of (c); and (e) production of D-pantolactone by treating the racemate with an L-pantolactone hydrolase.
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