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    41.
    发明专利
    未知

    公开(公告)号：DK1720999T3

    公开(公告)日：2009-05-04

    申请号：DK05713781

    申请日：2005-02-18

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： MARTIS LEO ,  PATEL MEHUL ,  GIERTYCH JOSEPH A ,  MONGOVEN JAMES W ,  KUNZLER JACQUELINE A ,  OWEN WILLIAM F JR

    IPC: C12Q1/37 ,  C12Q1/04 ,  C12Q1/26 ,  G01N33/569

    Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

    Biocompatible dialysis fluids containing icodextrins
    42.
    发明专利
    Biocompatible dialysis fluids containing icodextrins 未知

    公开(公告)号：AU2003299683B2

    公开(公告)日：2008-10-02

    申请号：AU2003299683

    申请日：2003-12-18

    Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

    Inventor： CHOO CAROLYN ,  MARTIS LEO ,  ZIESKE PAUL

    IPC: A61K31/718 ,  A61K31/724 ,  A61M1/28

    Abstract: Icodextrin-based solutions and methods of making same that can be used during medical therapy, such as dialysis therapy are provided. The icodextrin-based solution at least includes a first solution containing icodextrin at a pH ranging from about 1.5 to about 5.0 and a buffer solution at a pH ranging from about 7.0 to about 12.0 that are so constructed and arranged allowing the icodextrin-based solution to be mixed prior to infusion into a patient. The icodextrin-based solutions of the present invention can be made at physiologic pH and with minimal glucose degradation products.

    SYSTEMS AND METHODS FOR PERFORMING PERITONEAL DIALYSIS
    46.
    发明专利
    SYSTEMS AND METHODS FOR PERFORMING PERITONEAL DIALYSIS 未知

    公开(公告)号：AU2003249296A1

    公开(公告)日：2004-02-09

    申请号：AU2003249296

    申请日：2003-07-16

    Applicant: BAXTER INT

    Inventor： CHILDERS ROBERT W ,  BROWN DAVID S ,  WARIAR RAMESH ,  KAROOR SUJATHA ,  DIN SHAHID ,  MARTIS LEO ,  BUCHMANN CODY ,  SOLTYS PAUL

    IPC: A61M1/14 ,  A61M1/16 ,  A61M1/28

    Abstract: A system for dialysis is disclosed. An example peritoneal dialysis system includes a peritoneal dialysis machine including a pumping mechanism, and a sensor configured to measure a property of peritoneal dialysis fluid. The peritoneal dialysis system also includes a disposable cassette operable with the peritoneal dialysis machine. The disposable cassette includes a fluid source inlet for accepting fluid from a fluid source and a fluid flow path in fluid communication with the fluid source inlet. The fluid flow path includes a pump chamber operable with the pumping mechanism to pump fluid through the fluid flow path. The disposable cassette also includes a concentrate inlet for fluidly communicating concentrate to the fluid flow path, and a sensor chamber located along the fluid flow path and operable with the sensor. The sensor is configured to provide feedback to the peritoneal dialysis machine for mixing the concentrate for forming peritoneal dialysis fluid.

    47.
    发明专利
    未知

    公开(公告)号：AT246508T

    公开(公告)日：2003-08-15

    申请号：AT95908701

    申请日：1995-01-23

    Applicant: BAXTER INT

    Inventor： MARTIS LEO ,  BURKE RON ,  SHOCKLEY TY ,  HENDERSON LEE W ,  FALLER BERNARDETTE

    IPC: A61M1/14 ,  A61K31/715 ,  A61K33/14 ,  A61M1/28

    Abstract: The method relates to providing an osmotic agent for a peritoneal dialysis solution containing sodium chloride and optionally lactate, bicarbonate, calcium and magnesium ions. The osmotic agent added comprises a first composition with a weight average molecular weight of ≥ 10,000 daltons and 0.25 to 2.0 (% w/v) of a second composition with a weight average molecular weight of ≤ 300 daltons.

    48.
    发明专利
    未知

    公开(公告)号：AT222766T

    公开(公告)日：2002-09-15

    申请号：AT95921482

    申请日：1995-05-25

    Applicant: BAXTER INT

    Inventor： MARTIS LEO ,  HENDERSON LEE W

    IPC: A61K9/08 ,  A61K31/19 ,  A61K31/194 ,  A61K31/70 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/10 ,  A61K33/14 ,  A61M1/28 ,  A61P7/08 ,  A61P13/12 ,  A61M1/16

    Abstract: A peritoneal dialysis solution that is biochemically balanced to correct metabolic acidosis associated with chronic renal failure in a more physiological manner. The peritoneal dialysis solution has a physiological pH, e.g. pH of 70 to 74 and contains bicarbonate at a concentration that is found in normal blood. Additionally, the solution contains carbon dioxide at a partial pressure that is similar to partial pressure of carbon dioxide found in normal blood. The peritoneal dialysis solution also contains a weak acid with a pKa of less than 5.0.

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