公开(公告)号：ES2106104T3

公开(公告)日：1997-11-01

申请号：ES92107395

申请日：1992-04-30

Applicant: HOECHST AG

Inventor： LERCH ULRICH DR ,  JENDRALLA JOACHIM-HEINER DR ,  SEURING BERNHARD DR ,  HENNING RAINER DR

IPC: C07B61/00 ,  C07C231/02 ,  C07C231/18 ,  B01J31/24 ,  C07C233/14 ,  C07C233/22 ,  C07C233/40 ,  C07D211/44 ,  C07D211/58 ,  C07D241/04 ,  C07F9/572 ,  C07F15/00

Abstract: Two processes for the preparation of the optically pure compounds of the general formula 1 are described in which R and R are, for example, alkyl, R and R are, for example, hydrogen and R is, for example, hydrogen. Both processes include the enantioselective hydrogenation of a C=C double bond and the regioselective monoamide formation of a dicarboxylic acid derivative as key steps.

公开(公告)号：GR3022548T3

公开(公告)日：1997-05-31

申请号：GR970400238

申请日：1997-02-12

Applicant: HOECHST AG

Inventor： LERCH ULRICH DR ,  JENDRALLA JOACHIM-HEINER DR ,  SEURING BERNHARD DR ,  HENNING RAINER DR

IPC: C07F9/50 ,  C07C45/50 ,  C07F9/572 ,  C07F15/00

公开(公告)号：CZ280584B6

公开(公告)日：1996-02-14

申请号：CS225991

申请日：1991-07-19

Applicant: HOECHST AG

Inventor： HENNING RAINER DR ,  WAGNER ADALBERT DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07D233/56 ,  C07D233/90 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Substd. azole derivs. of formula (I) and their physiologically acceptable salts are new. In (I) X, Y and Z are each N or CR2 R1 is 2-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, -(CH2)mB(CH2nR4 (these 4 gps. opt. monosubstd. with CO2R3 and opt. have 1-all H atoms replaced by F), OR3, 3-8C cycloalkyl, 5-10C cycloalkylalkynyl, or benzyl (opt. mono or disubstd. on the Ph ring with halogen, 1-4C alkoxy and/or NO2), R2 = H, halogen, CvF2v+1, SF5, pentafluoro phenyl CN, phenyl, -(CH2)nF, -(CH2)nONO2, -CH2N3, -(CH2)nNO2, phthalimido (CH2)n-, R3 = H, 1-8C alkyl (in which 1 to all H are replaced by F), 3-8C cycloalkyl, Ph or benzyl, R4 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-4C alkenyl, or 2-4C alkynyl, A = a mono or bicyclic unsatd. or partially hydrogenated heterocycle gp. with 5-10 ring atom of which up to 9 are C, and opt. substd. with up to 3 opt. different R14 gps. or -(CH2)n-1-(CHR6CH2)0-1, R14 where R14 = halogen, oxo, nitroso, NO2, amino, CN, OH, 1-6C alkyl, 1-4C alkanoyl, 1-4C alkanoyloxy. B = O, NR7 or S, W = O or S, L = 1-3C alkanediyl, R26 and R27 are each H, halogen, NO2, 1-4C alkyl or 1-2C alkoxy, n = 1-5, o = 1-10, q = 0-1.

公开(公告)号：DE58907505D1

公开(公告)日：1994-05-26

申请号：DE58907505

申请日：1989-11-21

Applicant: HOECHST AG

Inventor： HENNING RAINER DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  SCHOELKENS BERNWARD DR

IPC: C07D213/40 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  C07D233/64 ,  C07D401/12 ,  C07D409/12 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/64

Abstract: The invention relates to compounds of the formula I in which A is a radical of the formula II in which E is a CH2 group or a radical NR , G is a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B is an amino acid, D is a heterocycle, and R , R , R , R , R , R and R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to the use thereof as medicines.

公开(公告)号：ES2043626T3

公开(公告)日：1994-01-01

申请号：ES87114164

申请日：1987-09-29

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  HENNING RAINER DR ,  RUGER WOLFGANG DR ,  TEETZ WOLFGANG DR ,  URBACH HANSJORG DR

IPC: A61K31/40 ,  A61K31/401 ,  A61K31/435 ,  A61K31/44 ,  A61K38/05 ,  A61K38/55 ,  A61K45/06 ,  A61P3/00 ,  A61P3/14 ,  A61P9/12 ,  A61P43/00 ,  A61K37/64

Abstract: The combinations are produced as described and used as medicines.

公开(公告)号：CZ9203811A3

公开(公告)日：1993-12-15

申请号：CS381192

申请日：1992-12-21

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  WAGNER ADALBERT DR ,  GERHARDS HERMANN DR ,  BECKER REINHARD DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/64 ,  A61P9/10 ,  A61P9/12 ,  C07D233/84 ,  C07D233/86 ,  C07D233/90

CPC classification number: C07D233/84 ,  C07D233/90

公开(公告)号：DE59002721D1

公开(公告)日：1993-10-21

申请号：DE59002721

申请日：1990-08-08

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG DR ,  SCHOELKENS BERNWARD PROF DR ,  SCHOLZ WOLFGANG DR ,  WIEMER GABRIELE DR ,  URBACH HANSJOERG DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K37/64 ,  A61K37/02

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.

公开(公告)号：CZ187992A3

公开(公告)日：1993-01-13

申请号：CS187992

申请日：1992-06-18

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  URBACH HANSJORG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00

Abstract: Heterocyclic compounds of the formula (I) in which the radicals have the following meanings: R is, for example, propyl or isobutyl, R is, for example, phenyl or pyridyl, R is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydrogen or hydroxyl, R is, for example, a radical of the formula (II> (CH2)5-CHR -Z (II> where R is, for example, hydrogen, Z represents a 5- to 7-membered heterocyclic ring and s denotes 0, 1, 2, 3 or 4; are potent renin-inhibiting compounds.

公开(公告)号：CS9102259A3

公开(公告)日：1992-06-17

申请号：CS225991

申请日：1991-07-19

Applicant: HOECHST AG

Inventor： HENNING RAINER DR ,  WAGNER ADALBERT DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07D233/56 ,  C07D233/90 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D207/325 ,  A61K31/40 ,  A61K31/41 ,  C07D231/12 ,  C07D233/54 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04

CPC classification number: C07D403/10 ,  C07D233/90 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

公开(公告)号：DE3685177D1

公开(公告)日：1992-06-11

申请号：DE3685177

申请日：1986-08-29

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  GEIGER ROLF PROF DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  URBACH HANSJOERG DR

IPC: A61K45/06 ,  A61K31/40 ,  A61K31/635 ,  A61K38/00 ,  A61K38/55 ,  A61P7/10 ,  A61P9/12 ,  A61P43/00

Abstract: The preparation contains an angiotensin converting enzyme inhibitor and a loop diuretic.