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    AMINOALKYL- AND ACYLAMINOALKYL ETHERS PROCESS OF THEIR PREPARATION AND THEIR USE AS ANTAGONIZING AGENTS OF BRADYKININ RECEPTORS
    42.
    发明专利
    AMINOALKYL- AND ACYLAMINOALKYL ETHERS PROCESS OF THEIR PREPARATION AND THEIR USE AS ANTAGONIZING AGENTS OF BRADYKININ RECEPTORS 未知

    公开(公告)号：CZ76697A3

    公开(公告)日：1997-10-15

    申请号：CZ76697

    申请日：1997-03-12

    Applicant: HOECHST AG

    Inventor： HEITSCH HOLGER DR ,  WAGNER ADALBERT DR ,  WIRTH KLAUS DR ,  SCHOLKENS BERNWARD PROF DR ,  NOLKEN GERHARD DR

    IPC: C07D215/48 ,  A61K31/47 ,  A61P43/00 ,  C07D215/26

    Abstract: 8-(3-(Aminoalkoxy)-benzyloxy)-quinoline compounds of formula (I) and their salts are new. R1-R3 = H, halo, CHO, COOH, 1-5C alkyl, 6-10C aryl, 1-3C alkyl-(6-10C) aryl, 3-8C cycloalkyl or 1-3C alkoxycarbonyl; R4, R5 = H, halo, NO2, CN, 1-3C alkoxy or 1-3C alkylthio; R6 = H, 1-3C alkyl, 3-5C alkylalkenyl (sic) or 1-3C alkyl-6-10C aryl; R7 = H, 1-6C alkanoyl, alkanoyl (substituted by 1-3C alkoxy, alkylcarbamoyl or aryl), 3-7C alkenoyl, 3-8C cycloalkylcarbonyl, 5-7C cycloalkenylcarbonyl, 1-3C alkoxycarbonyl, aryloxycarbonyl, 6-12C aroyl (optionally substituted by 1-3C alkoxy or halo), alkenoyl (substituted by aryl (optionally substituted by 1-3C alkoxy, 1-3C alkylenedioxy, NO2, CN, halo, 1-3C haloalkyl, hetero-3-8C cycloalkyl (sic), NH2, 1-4C alkylamino, 6-12C heteroaryl-alkanoylamino, aroylamino, 6-12C heteroarylcarbonylamino, 1-5C alkylsulphonylamino, 1-5C alkylureido, alkanoyl, 1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl or arylcarbamoyl), 2-5C acylamino-arylcinnamoyl, 1-3C alkoxycarbonylamino-arylcinnamoyl, 1-4C alkylaminocarbonylaminocinnamoyl, aryl-1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl, arylcarbamoyl, aroylcarbamoyl, alkylsulphonyl, arylsulphonyl, aryl-alkylsulphonyl or phthaloyl (for R6=R7(sic)); n = 1-8; alkyl has 1-6C, aryl has 6-12C, alkanoyl has 2-6C, and alkenoyl has 3-6C unless specified other wise.

    43.
    发明专利
    未知

    公开(公告)号：ID16217A

    公开(公告)日：1997-09-11

    申请号：ID970758

    申请日：1997-03-10

    Applicant: HOECHST AG

    Inventor： HEITSCH HOLGER DR ,  WAGNER ADALBERT DR ,  WIRTH KLAUS DR ,  SCHOLKENS BERNWARD PROF DR ,  NOLKEN GERHARD DR

    IPC: C07D215/48 ,  A61K31/47 ,  A61P43/00 ,  C07D215/26

    Abstract: 8-(3-(Aminoalkoxy)-benzyloxy)-quinoline compounds of formula (I) and their salts are new. R1-R3 = H, halo, CHO, COOH, 1-5C alkyl, 6-10C aryl, 1-3C alkyl-(6-10C) aryl, 3-8C cycloalkyl or 1-3C alkoxycarbonyl; R4, R5 = H, halo, NO2, CN, 1-3C alkoxy or 1-3C alkylthio; R6 = H, 1-3C alkyl, 3-5C alkylalkenyl (sic) or 1-3C alkyl-6-10C aryl; R7 = H, 1-6C alkanoyl, alkanoyl (substituted by 1-3C alkoxy, alkylcarbamoyl or aryl), 3-7C alkenoyl, 3-8C cycloalkylcarbonyl, 5-7C cycloalkenylcarbonyl, 1-3C alkoxycarbonyl, aryloxycarbonyl, 6-12C aroyl (optionally substituted by 1-3C alkoxy or halo), alkenoyl (substituted by aryl (optionally substituted by 1-3C alkoxy, 1-3C alkylenedioxy, NO2, CN, halo, 1-3C haloalkyl, hetero-3-8C cycloalkyl (sic), NH2, 1-4C alkylamino, 6-12C heteroaryl-alkanoylamino, aroylamino, 6-12C heteroarylcarbonylamino, 1-5C alkylsulphonylamino, 1-5C alkylureido, alkanoyl, 1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl or arylcarbamoyl), 2-5C acylamino-arylcinnamoyl, 1-3C alkoxycarbonylamino-arylcinnamoyl, 1-4C alkylaminocarbonylaminocinnamoyl, aryl-1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl, arylcarbamoyl, aroylcarbamoyl, alkylsulphonyl, arylsulphonyl, aryl-alkylsulphonyl or phthaloyl (for R6=R7(sic)); n = 1-8; alkyl has 1-6C, aryl has 6-12C, alkanoyl has 2-6C, and alkenoyl has 3-6C unless specified other wise.

    New carbamoyl substituted piperidine carbonyl peptide derivatives
    44.
    发明专利
    New carbamoyl substituted piperidine carbonyl peptide derivatives 未知

    公开(公告)号：DE19546938A1

    公开(公告)日：1997-06-19

    申请号：DE19546938

    申请日：1995-12-15

    Applicant: HOECHST AG

    Inventor： WAGNER ADALBERT DR ,  BREIPOHL GERHARD DR ,  HEITSCH HOLGER DR ,  GERHARDS HERMANN DR ,  NOELKEN GERHARD DR ,  WIRTH KLAUS DR ,  SCHOELKENS BERNWARD PROF DR

    IPC: A61K38/00 ,  C07K5/02 ,  C07K7/18 ,  A61K38/06 ,  A61K38/07

    Abstract: 1-Carbamoyl-4-piperidinecarbonyl di- and tripeptides (I) and their salts are new: R = H, 2-6C alkyl, NR R or -N(R )=C(NHR )(NHR ); R = 1-10C alkyl, 2-10C alkenyl, 3-10C alkynyl or -(CH2)m-B-(CH2)n-R (all optionally monosubstituted by CO2R or by 1 or more halo), OR , 3-8C cycloalkyl, 4-10C cycloalkyl-1-4C alkyl, 5-10C cycloalkyl-2-4C alkenyl, 5-10C cycloalkyl-2-4C alkynyl or 6-10C aryl (optionally mono- or disubstituted by halo, 1-4C alkoxy, NO2 or CN); R = H, 1-8C alkyl, 3-8C cycloalkyl, phenyl, benzyl, 1-8C alkoxy-CO- or 1-4C alkyl-6-10C aryloxy-CO-; R = H, 1-6C alkyl, 3-8C cycloalkyl, 2-4C alkenyl or 2-4C alkynyl; R = H, 1-6C alkyl, 3-8C cycloalkyl, phenyl or benzyl; B = O, NR or S; n = 1-5; m = 0-5; o, p = 1-10; A1 = a bond, Phe, 2-, 3- or 4-Cl- or 2-, 3- or 4-F-phenylalanine, Tyr, Tyr(OMe), Thi, Gly, Cha, Leu, Ile, Val, Nle or Phg; A2 = a bond, Gly, Ser, Hser, Lys, Leu, Val, Nle, Ile or Cys; and A3, A4 = a bond or a heterocyclic group of e.g. formula (A) to (C).

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