公开(公告)号：DD297063A5

公开(公告)日：1992-01-02

申请号：DD34336690

申请日：1990-08-09

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  SCHOLZ WOLFGANG ,  WIEMER GABRIELE ,  URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K37/02

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.

公开(公告)号：ZA9006327B

公开(公告)日：1991-05-29

申请号：ZA9006327

申请日：1990-08-10

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  WOLFGANG LINZ ,  URBACH HANSJOERG ,  HANSJOERG URBACH ,  HENNING RAINER ,  RAINER HENNING ,  SCHOELKENS BERNWARD ,  BERNWARD SCHOELKENS ,  SCHOLZ WOLFGANG ,  WOLFGANG SCHOLZ ,  TEETZ VOLKER ,  VOLKER TEETZ ,  WIEMER GABRIELE ,  GABRIELE WIEMER

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K

CPC classification number: A61K38/556

公开(公告)号：ZA8906717B

公开(公告)日：1990-05-30

申请号：ZA8906717

申请日：1989-09-01

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  WOLF-ULRICH NICKEL ,  HENNING RAINER ,  RAINER HENNING ,  RUEGER WOLFGANG ,  WOLFGANG RUEGER ,  LERCH ULRICH ,  ULRICH LERCH ,  URBACH HANSJOERG ,  HANSJOERG URBACH ,  HOCK FRANZ ,  FRANZ HOCK ,  WIEMER GABRIELE ,  GABRIELE WIEMER

IPC: A61K31/495 ,  A61P25/00 ,  A61P25/28 ,  C07D241/08 ,  C07D403/04 ,  C07D405/04 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D513/04 ,  C07K1/113 ,  C07K5/06 ,  C07D ,  A61K ,  C07K

CPC classification number: C07D487/04 ,  C07D241/08

公开(公告)号：AU8246087A

公开(公告)日：1988-08-18

申请号：AU8246087

申请日：1987-12-11

Applicant: HOECHST AG

Inventor： KUNSTMANN RUDOLF ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: C07D209/14 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/18 ,  A61P25/28 ,  C07C231/00 ,  C07C231/02 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07D209/16 ,  C07D211/14 ,  C07D211/30 ,  C07D211/70 ,  C07D295/14 ,  C07D295/15 ,  C07D307/66 ,  C07D307/82 ,  C07D333/20 ,  C07D333/58 ,  A61K31/44 ,  C07C103/50 ,  A61K31/405

Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.

公开(公告)号：FI875432A

公开(公告)日：1988-06-13

申请号：FI875432

申请日：1987-12-10

Applicant: HOECHST AG

Inventor： KUNSTMANN RUDOLF ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: C07D209/14 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/18 ,  A61P25/28 ,  C07C231/00 ,  C07C231/02 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07D209/16 ,  C07D211/14 ,  C07D211/30 ,  C07D211/70 ,  C07D295/14 ,  C07D295/15 ,  C07D307/66 ,  C07D307/82 ,  C07D333/20 ,  C07D333/58 ,  C07D

Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.

公开(公告)号：DK651987D0

公开(公告)日：1987-12-11

申请号：DK651987

申请日：1987-12-11

Applicant: HOECHST AG

Inventor： KUNSTMANN RUDOLF ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: C07D209/14 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/18 ,  A61P25/28 ,  C07C231/00 ,  C07C231/02 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07D209/16 ,  C07D211/14 ,  C07D211/30 ,  C07D211/70 ,  C07D295/14 ,  C07D295/15 ,  C07D307/66 ,  C07D307/82 ,  C07D333/20 ,  C07D333/58 ,  C07C103/50 ,  C07C101/04 ,  C07C103/66 ,  C07D211/34 ,  C07D211/78

Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.

公开(公告)号：FI875432A0

公开(公告)日：1987-12-10

申请号：FI875432

申请日：1987-12-10

Applicant: HOECHST AG

Inventor： KUNSTMANN RUDOLF ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: C07D209/14 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/18 ,  A61P25/28 ,  C07C231/00 ,  C07C231/02 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07D209/16 ,  C07D211/14 ,  C07D211/30 ,  C07D211/70 ,  C07D295/14 ,  C07D295/15 ,  C07D307/66 ,  C07D307/82 ,  C07D333/20 ,  C07D333/58 ,  C07D

Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.