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    Method for producing phthalimidoacetaldehyde
    41.
    发明专利
    Method for producing phthalimidoacetaldehyde 审中-公开
    生产邻苯二甲酰二胺的方法

    公开(公告)号：JP2007055922A

    公开(公告)日：2007-03-08

    申请号：JP2005241942

    申请日：2005-08-24

    Applicant: Kaneka Corp ,  株式会社カネカ

    Inventor： AMANO SUSUMU ,  KAWASAKI HIROAKI ,  FUJII AKIO ,  MOROSHIMA TADASHI ,  WATABE KAZUHIKO ,  MITSUDA MASARU

    IPC: C07D209/48

    Abstract: PROBLEM TO BE SOLVED: To provide a method for safely and effectively producing industrially useful phthalimidoacetaldehyde and a phthalimidoacetaldehyde dialkyl acetal. SOLUTION: In this method, a phthalimidoacetaldehyde acetal derivative is prepared by making phthalimide, a base, and the like act on a haloacetaldehyde acetal derivative. The phthalimidoacetaldehyde is produced by making an acid act on the obtained phthalimidoacetaldehyde acetal derivative. COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题：提供安全有效地生产工业上有用的苯二甲酰亚氨基乙醛和苯二甲酰亚氨基乙醛二烷基缩醛的方法。 解决方案：在该方法中，通过使邻苯二甲酰亚胺，碱等作用于卤代乙醛缩醛衍生物来制备苯二甲酰亚氨基乙醛缩醛衍生物。 通过使所得的苯二甲酰亚氨基乙醛缩醛衍生物发生酸作用来制造苯二甲酰亚氨基乙醛。 版权所有（C）2007，JPO＆INPIT

    PROCESS FOR PREPARING PHARMACOLOGICALLY ACCEPTABLE SALTS OF N-(1(S)-ETHOXYCARBONYL-3-PHENYLPROPYL)-L-ALANYL-AMINO ACIDS
    43.
    发明专利
    PROCESS FOR PREPARING PHARMACOLOGICALLY ACCEPTABLE SALTS OF N-(1(S)-ETHOXYCARBONYL-3-PHENYLPROPYL)-L-ALANYL-AMINO ACIDS 未知

    公开(公告)号：CA2266757C

    公开(公告)日：2010-10-19

    申请号：CA2266757

    申请日：1998-07-21

    Applicant: KANEKA CORP

    Inventor： UEDA YASUYOSHI ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  FUSE YOSHIHIDE

    IPC: C07K5/062 ,  A61P9/12 ,  C07K1/02 ,  C07K1/08 ,  C07K5/02 ,  C07K5/06

    Abstract: There is provided a process for preparing a pharmacologically acceptable salt of N-(1(S)--ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid which comprises condensing an amino acid and N--(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine- N-carboxy-anhydride under basic condition, carrying out decarboxylation under between neutral and acidic condition to obtain N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid, and forming a pharmacologically acceptable salt thereof, wherein the production of a by-product (3): (see formula 3) is suppressed by carrying out in an aqueous liquid a series of operations till formation of the pharmacologically acceptable salt or till isolation of the pharmacologically acceptable salt. The present invention enables to prepare the pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid having high quality, in a commercial scale with high yield and economical efficiency.

    PROCEDIMIENTO PARA PREPARAR SALES FARMACOLOGICAMENTE ACEPTABLES DE N-1(S)-ETOXICARBONIL-3-FENILPROPIL)-L-ALANIL AMINOACIDOS.
    45.
    发明专利
    PROCEDIMIENTO PARA PREPARAR SALES FARMACOLOGICAMENTE ACEPTABLES DE N-1(S)-ETOXICARBONIL-3-FENILPROPIL)-L-ALANIL AMINOACIDOS. 未知

    公开(公告)号：ES2241149T3

    公开(公告)日：2005-10-16

    申请号：ES98932585

    申请日：1998-07-21

    Applicant: KANEKA CORP

    Inventor： UEDA YASUYOSHI ,  KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  FUSE YOSHIHIDE

    IPC: A61P9/12 ,  C07K1/02 ,  C07K1/08 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062

    Abstract: UN PROCEDIMIENTO PARA LA PREPARACION DE SALES DE N - (1(S) ETOXICARBONIL - 3 - FENILPROPIL) - L - ALANILAMINOACIDOS FARMACOLOGICAMENTE ACEPTABLES QUE CONSISTE EN LOS PASOS SIGUIENTES: SE CONDENSA UN AMINOACIDO CON N - CARBOXIANHIDRIDO DE N - (1(S) - ETOXICARBONIL - 3 - FENILPROPIL) - L - ALANINA BAJO CONDICIONES BASICAS; SE DESCARBOXILA EL CONDENSADO BAJO CONDICIONES DE NEUTRAS A ACIDAS PARA PREPARAR UN N - (1(S) ETOXICARBONIL 3 - FENILPROPIL) - L - ALANILAMINOACIDO; Y SE CONVIERTE EL PRODUCTO EN UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO, QUE SE CARACTERIZA PORQUE SE LLEVAN A CABO UNA SERIE DE PROCEDIMIENTOS HASTA LA FORMACION DE UNA SAL FARMACOLOGICAMENTE ACEPTABLE O HASTA LA RETIRADA DE LA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO EN UN LIQUIDO ACUOSO PARA INHIBIR LA PRODUCCION DE UN SUBPRODUCTO (4). SEGUN ESTE PROCEDIMIENTO, SE PUEDEN PREPARAR SALES DE N - (1(S) ETOXICARBONIL - 3 - FENILPROPIL) - L - ALANILAMINOACIDOS FARMACOLOGICAMENTE ACEPTABLES EN GRANDES CANTIDADES DE MANERA ECONOMICA A ESCALA COMERCIAL.

    46.
    发明专利
    未知

    公开(公告)号：ES2215624T3

    公开(公告)日：2004-10-16

    申请号：ES00915524

    申请日：2000-04-14

    Applicant: KANEKA CORP

    Inventor： KINOSHITA KOICHI ,  MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  NAGASHIMA NOBUO ,  SAKA YASUHIRO ,  HONDA TATSUYA

    IPC: C07C29/147 ,  C07C31/42 ,  C07D307/20

    Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.

    PROCESS FOR THE PREPARATION OF N2-(1(S)-CARBOXY-3-PHENYLPROPYL)-L-LYSYL-L-PROLINE
    48.
    发明专利
    PROCESS FOR THE PREPARATION OF N2-(1(S)-CARBOXY-3-PHENYLPROPYL)-L-LYSYL-L-PROLINE 未知

    公开(公告)号：HU0100831A2

    公开(公告)日：2001-08-28

    申请号：HU0100831

    申请日：1999-09-22

    Applicant: KANEKA CORP

    Inventor： FUSE YOSHIHIDE ,  MOROSHIMA TADASHI ,  UEDA YASUYOSHI ,  YANAGIDA YOSHIFUMI

    IPC: C07K5/068 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02

    Abstract: The process for producing N -(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline in a simple, efficient and industrially advantageous manner, which comprises: the first step of subjecting the N -(1(S)-alkoxycarbonyl-3-phenylpropyl)-N -trifluoroacetyl-L-lysyl -L-proline (1) to alkali hydrolysis in a mixed solution composed of water and a hydrophilic organic solvent using an inorganic base in an amount of n molar equivalents (n >/= 3) per mole of the above compound (1), the second step of neutralizing the hydrolysis product using an inorganic acid in an amount of (n - 1) to n molar equivalents (n >/= 3) and removing the inorganic salt formed by causing the same to precipitate out from a solvent system suited for decreasing the solubility of the inorganic salt, and the third step of causing the compound (2) existing in the mixture after removal of the inorganic salt to crystallize out at the isoelectric point thereof and thereby recovering the compound (2) in the form of crystals while retaining the salts comprising the trifluoroacetic acid-derived organic acid salt in a state dissolved in the mother liquor.

    METHOD OF OBTAINING N2-(1(S)-CARBOXY-3-PHENYLPROPYL)-L-LYSIL-L-PROLINE
    49.
    发明专利
    METHOD OF OBTAINING N2-(1(S)-CARBOXY-3-PHENYLPROPYL)-L-LYSIL-L-PROLINE 未知

    公开(公告)号：PL340685A1

    公开(公告)日：2001-02-26

    申请号：PL34068599

    申请日：1999-09-22

    Applicant: KANEKA CORP

    Inventor： MOROSHIMA TADASHI ,  YANAGIDA YOSHIFUMI ,  FUSE YOSHIHIDE ,  UEDA YASUYOSHI

    IPC: C07K5/068 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02

    Abstract: The process for producing N -(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline in a simple, efficient and industrially advantageous manner, which comprises: the first step of subjecting the N -(1(S)-alkoxycarbonyl-3-phenylpropyl)-N -trifluoroacetyl-L-lysyl -L-proline (1) to alkali hydrolysis in a mixed solution composed of water and a hydrophilic organic solvent using an inorganic base in an amount of n molar equivalents (n >/= 3) per mole of the above compound (1), the second step of neutralizing the hydrolysis product using an inorganic acid in an amount of (n - 1) to n molar equivalents (n >/= 3) and removing the inorganic salt formed by causing the same to precipitate out from a solvent system suited for decreasing the solubility of the inorganic salt, and the third step of causing the compound (2) existing in the mixture after removal of the inorganic salt to crystallize out at the isoelectric point thereof and thereby recovering the compound (2) in the form of crystals while retaining the salts comprising the trifluoroacetic acid-derived organic acid salt in a state dissolved in the mother liquor.

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