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公开(公告)号:WO2004046826A2
公开(公告)日:2004-06-03
申请号:PCT/US0336670
申请日:2003-11-12
Applicant: MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , DEYOUNG JAMES P
Inventor: MCCLAIN JAMES B , DEYOUNG JAMES P
IPC: G03F20060101 , G03F7/00 , G03F7/32 , G03F7/36 , G03F
Abstract: A method for carrying out positive tone lithography with a carbon dioxide solvent system is carried out by (a) providing a substrate having a polymer resist layer formed thereon; (b) exposing at least one portion of the polymer resist layer to radiant energy to form at least one light field region in the polymer resist layer; and then (c) contacting the polymer resist layer to a carbon dioxide solvent system, the solvent system preferably comprising a polar group, under conditions in which the at least one light field region is preferentially removed.
Abstract translation: 通过(a)提供其上形成有聚合物抗蚀剂层的基材,进行用二氧化碳溶剂系统进行正色调光刻的方法; (b)将聚合物抗蚀剂层的至少一部分暴露于辐射能以在聚合物抗蚀剂层中形成至少一个光场区域; 然后(c)在其中优选除去所述至少一个光场区域的条件下,使所述聚合物抗蚀剂层与二氧化碳溶剂体系接触,所述溶剂体系优选包含极性基团。
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公开(公告)号:WO2012034079A3
公开(公告)日:2012-05-18
申请号:PCT/US2011051092
申请日:2011-09-09
Applicant: MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , CARLYLE WENDA C , TAYLOR CHARLES DOUGLAS
Inventor: MCCLAIN JAMES B , CARLYLE WENDA C , TAYLOR CHARLES DOUGLAS
IPC: A61K9/00
CPC classification number: A61K9/7007 , A61K9/0019 , A61K9/0021 , A61K31/436 , A61K47/34
Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.
Abstract translation: 提供了包含至少一种聚合物和至少一种活性剂的药物递送组合物; 其中所述活性剂以结晶形式存在于所述组合物的外表面的至少一个区域上,并且其中调节活性剂表面含量以提供选定的活性剂释放曲线。
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公开(公告)号:WO2010111196A3
公开(公告)日:2011-03-31
申请号:PCT/US2010028195
申请日:2010-03-22
Applicant: MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , TAYLOR DOUGLAS
Inventor: MCCLAIN JAMES B , TAYLOR DOUGLAS
CPC classification number: A61L31/10 , A61F2/86 , A61F2240/001 , A61F2250/001 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2300/63 , A61L2420/02 , A61L2420/06 , A61L2420/08
Abstract: Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
Abstract translation: 本文提供了一种涂覆的冠状动脉支架,包括:a。 支架; 湾 沉积在所述支架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物,并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。
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公开(公告)号:WO9949122A9
公开(公告)日:2000-01-20
申请号:PCT/US9906383
申请日:1999-03-23
Applicant: MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , SCHREBE GARY , GRAKAUSKAS KENNETH , ROMACK TIMOTHY J
Inventor: MCCLAIN JAMES B , SCHREBE GARY , GRAKAUSKAS KENNETH , ROMACK TIMOTHY J
CPC classification number: D06F43/007 , D06F37/28 , D06F37/308 , D06F43/00 , D06F43/02 , D06F43/08
Abstract: A wash tank (10) adapted for use with a carbon dioxide cleaning medium has a body member (20) having a front opening (22) formed therein, the body member having side walls (23) and a back wall (24) opposite the front opening. The side walls terminate in a front body member edge portion (25) that defines the front opening. A substantially cylindrical basket (30) is disposed within the body member for rotation about a generally horizontal axis. The basket side wall terminates in a front basket edge portion defining the basket front opening. The said basket edge portion (32) is spaced forward from the body member edge portion (25) when the basket is positioned in the body member, serving to prevent loose garments or materials placed within the basket from becoming caught in the seal and interfering with seal integrity. A drive mechanism (50) is included to rotate the basket about the axis. A door (21) is hingeably (26) connected to the body member, with the door having a front wall and side walls, and with the side walls terminating in an inner edge portion (29) configured to abut said body member edge portion. The door inner edge portion (29) and the body member edge portion (25) comprise a seal for sealing the door and body member to form an enclosed pressure vessel. A plug (65) is connected to the door, the plug having a surface portion configured to abut the basket front opening when the door is closed. Methods and systems employing the tank are also disclosed.
Abstract translation: 适于与二氧化碳清洁介质一起使用的洗涤槽(10)具有主体构件(20),其具有形成在其中的前开口(22),主体构件具有侧壁(23)和与其相对的后壁(24) 前开口 侧壁终止于限定前开口的前身部件边缘部分(25)中。 基本上圆柱形的篮子(30)设置在主体构件内,用于围绕大致水平的轴线旋转。 篮子侧壁终止于限定篮子前开口的前篮边缘部分。 当篮子位于主体构件中时,所述篮边缘部分(32)与主体构件边缘部分(25)间隔开,用于防止松散的衣服或放置在篮子内的材料被卡在密封件中并干扰 密封完整性。 包括驱动机构(50)以围绕轴旋转篮。 门(21)可铰接地连接到主体构件上,门具有前壁和侧壁,并且侧壁终止于构造成邻接所述主体构件边缘部分的内边缘部分(29)。 门内缘部分(29)和主体部件边缘部分(25)包括用于密封门和主体部件以形成封闭压力容器的密封件。 插头(65)连接到门上,插头具有被构造成当门关闭时邻接篮前开口的表面部分。 还公开了使用罐的方法和系统。
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公开(公告)号:CA2852260C
公开(公告)日:2020-09-22
申请号:CA2852260
申请日:2012-10-18
Applicant: MICELL TECHNOLOGIES INC
Inventor: MCCLAIN JAMES B , TAYLOR CHARLES DOUGLAS , FAGAN MEAGAN M
IPC: A61L29/08 , A61K9/00 , A61K31/436 , A61L29/16 , A61M31/00
Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.
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公开(公告)号:HK1252834A1
公开(公告)日:2019-06-06
申请号:HK18112162
申请日:2018-09-20
Applicant: MICELL TECHNOLOGIES INC
Inventor: KIORPES TIMOTHY CHARLES , MCCLAIN JAMES B
IPC: A61L20060101 , A61K20060101 , C08L20060101
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公开(公告)号:AU2014248508B2
公开(公告)日:2018-11-08
申请号:AU2014248508
申请日:2014-03-12
Applicant: MICELL TECHNOLOGIES INC
Inventor: MCCLAIN JAMES B , TAYLOR CHARLES DOUGLAS , BURGERMEISTER ROBERT STEVEN
IPC: A61F2/00
Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average strut thickness of no more than about 120 μιη. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.
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公开(公告)号:CA2721832C
公开(公告)日:2018-08-07
申请号:CA2721832
申请日:2009-04-17
Applicant: MICELL TECHNOLOGIES INC
Inventor: MCCLAIN JAMES B , TAYLOR DOUGLAS
Abstract: Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
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公开(公告)号:CA2805631C
公开(公告)日:2018-07-31
申请号:CA2805631
申请日:2011-07-15
Applicant: MICELL TECHNOLOGIES INC
Inventor: MCCLAIN JAMES B , TAYLOR CHARLES DOUGLAS , ZANI BRETT G , NEET JOHN , KIORPES TIMOTHY CHARLES
IPC: A61L29/08 , A61K9/00 , A61K31/436 , A61L29/16 , A61M31/00
Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
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公开(公告)号:CA2756307C
公开(公告)日:2017-08-08
申请号:CA2756307
申请日:2010-03-22
Applicant: MICELL TECHNOLOGIES INC
Inventor: MCCLAIN JAMES B , TAYLOR DOUGLAS
IPC: A61L31/10 , A61F2/82 , A61K31/436 , A61L27/34 , A61L27/54 , A61L31/02 , A61L31/12 , A61L31/14 , A61L31/16 , A61L31/18 , A61L33/10 , A61M31/00
Abstract: Provided herein is a coated stent having a plurality of stent struts for delivery to a peripheral body lumen comprising: a stent; a coating comprising a pharmaceutical agent and a polymer wherein at least part of the pharmaceutical agent is in crystalline form, and a fiber reinforcement on the stent; wherein the length of the fiber is up to 5 micrometers, and wherein the fiber reduces the penetration of struts through the coating upon stent strut breakage.
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