公开(公告)号：US10279974B2

公开(公告)日：2019-05-07

申请号：US14657535

申请日：2015-03-13

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： Yi Duan-Arnold ,  Alla Danilkovitch ,  Alexandra Gyurdieva ,  Jin-Qiang Kuang ,  Steven Michael Sinclair

IPC: B65D77/26 ,  B65D65/02 ,  B65D85/00 ,  B65B5/04 ,  B65B55/22 ,  A61F2/00 ,  A61F15/00 ,  A61F2/10 ,  A61B90/00

Abstract: A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.

公开(公告)号：US10265344B2

公开(公告)日：2019-04-23

申请号：US14291256

申请日：2014-05-30

Applicant: Osiris Therapeutics, Inc.

Inventor： Samson Tom ,  Alla Danilkovitch ,  Dana Yoo ,  Timothy Jansen ,  Jin-Qiang Kuang ,  Jennifer Michelle Marconi

IPC: A61K35/50 ,  A61K35/28 ,  C12N5/073 ,  A01N1/02 ,  A61K38/18 ,  A61K38/39 ,  A61K38/57

Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

公开(公告)号：US20160082155A1

公开(公告)日：2016-03-24

申请号：US14849509

申请日：2015-09-09

Applicant: Osiris Therapeutics, Inc.

Inventor： Thomas E. Uveges ,  Jin-Qiang Kuang ,  Alla Danilkovitch ,  S. Michael Sinclair ,  Sandra D. Geraghty

IPC: A61L27/38 ,  A61L27/36 ,  A61K38/18 ,  A61L27/54

Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.

Abstract translation: 本文提供了一种骨修复组合物，其由含有血管生成生长因子的骨膜，含有活的成骨细胞的松质骨碎片和任选的软化骨基质（DBM）芯片组成。 本文还提供了治疗骨缺损的制品及其使用方法。

公开(公告)号：US20140017292A1

公开(公告)日：2014-01-16

申请号：US13939991

申请日：2013-07-11

Applicant: Osiris Therapeutics, Inc.

Inventor： Dana Sue Yoo ,  Jin-Qiang Kuang ,  Jaime Paden ,  Scott A. Maxson ,  Alla Danilkovitch ,  Erasmo Lopez ,  Samson Tom

IPC: A61L27/56 ,  A61L27/36

CPC classification number: A61L27/3612 ,  A61K35/32 ,  A61K38/014 ,  A61L27/24 ,  A61L27/3608 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/06

Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.

Abstract translation: 本发明提供了有价软骨产品和生产门软骨产品的方法。 任选地，软骨产品的尺寸，开口和消化以提供柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。

公开(公告)号：US20140017283A1

公开(公告)日：2014-01-16

申请号：US13939969

申请日：2013-07-11

Applicant: Osiris Therapeutics, Inc.

Inventor： Dana Sue Yoo ,  Jin-Qiang Kuang ,  Jaime Paden ,  Scott A. Maxson ,  Alla Danilkovitch ,  Erasmo Lopez ,  Samson Tom

IPC: A61K35/32

CPC classification number: A61L27/3612 ,  A61K35/32 ,  A61K38/014 ,  A61L27/24 ,  A61L27/3608 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/06

Abstract: This invention provides porated cartilage products, methods of producing porated cartilage products, and methods of treating subjects by administering cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.

Abstract translation: 本发明提供了开放的软骨产品，生产门软骨产品的方法，以及通过施用软骨制品治疗受试者的方法。 任选地，软骨产品的尺寸，开口和消化以提供柔性软骨产品。 任选地，软骨产品包括活的软骨细胞，生物活性因子如软骨形成因子和II型胶原蛋白。 任选地，软骨产品是非免疫原性的。