-
公开(公告)号：US20170368105A1
公开(公告)日：2017-12-28
申请号：US15631707
申请日：2017-06-23
Applicant: Osiris Therapeutics, Inc.
Inventor： Steven Michael Sinclair , Alla Danilkovitch , Malathi Sathyamoorthy , Jin-Qiang Kuang , Sandeep Dhall , Yishan Liu , Anthony John Melchiorri , Matthew Robert Moorman , Mena Schiano Lo Moriello , Anne Allgood Lerch
CPC classification number: A61K35/50 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/19 , A61K35/33 , A61K35/51 , A61L26/0057 , A61L27/3604 , A61L27/3834 , A61P17/02 , A61P19/00 , A61P19/02 , A61P19/04 , A61P19/10 , A61P29/00
Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.
-
公开(公告)号：US10994913B2
公开(公告)日：2021-05-04
申请号：US16279413
申请日：2019-02-19
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Yi Duan-Arnold , Alla Danilkovitch , Alexandra Gyurdieva , Jin-Qiang Kuang , Steven Michael Sinclair
IPC: B65D77/26 , B65D65/02 , B65D85/00 , B65B5/04 , B65B55/22 , A61F2/00 , A61F15/00 , A61F2/10 , A61B90/00
Abstract: A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.
-
公开(公告)号：US11318168B2
公开(公告)日：2022-05-03
申请号：US15631707
申请日：2017-06-23
Applicant: Osiris Therapeutics, Inc.
Inventor： Steven Michael Sinclair , Alla Danilkovitch , Malathi Sathyamoorthy , Jin-Qiang Kuang , Sandeep Dhall , Yishan Liu , Anthony John Melchiorri , Matthew Robert Moorman , Mena Schiano Lo Moriello , Anne Allgood Lerch
IPC: A61K35/50 , A61K35/51 , A01N1/02 , A61K9/00 , A61K9/06 , A61K9/19 , A61K35/33 , A61P19/00 , A61P19/04 , A61P17/02 , A61P29/00 , A61P19/10 , A61P19/02 , A61L27/36 , A61L27/38 , A61L26/00
Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.
-
Patent Agency Ranking
公开(公告)号：US20160310280A1
公开(公告)日：2016-10-27
申请号：US15079867
申请日：2016-03-24
Applicant: Osiris Therapeutics, Inc.
Inventor： Alla Danilkovitch , Jinqiang Kuang , Steven Michael Sinclair
CPC classification number: A61F2/30756 , A61F2/3094 , A61F2/3872 , A61F2002/30006 , A61F2002/30047 , A61F2002/30807 , A61F2250/00 , A61F2310/00371 , A61L27/3604 , A61L27/3612 , A61L27/3654 , A61L27/3852 , A61L27/54 , A61L2300/414
Abstract: Disclosed are compositions comprising a meniscal tissue. For example, disclosed are compositions comprising a meniscal tissue, wherein the meniscal tissue comprises one or more engineered channels. Disclosed are compositions comprising a meniscal tissue comprising viable cells native to the meniscal tissue and devitalized blood vessels. Disclosed are compositions comprising a previously cryopreserved meniscal tissue, wherein after cryopreservation and subsequent thawing the meniscal tissue comprises a) cells native to the meniscal tissue and greater than 30% of the cells are viable, b) extracellular matrix that is native to the meniscal tissue, c) one or more growth factors that are native to the meniscal tissue, and d) depleted amounts of one or more types of functional immunogenic cells. Also disclosed are methods of producing and using these compositions comprising meniscal tissue.
Abstract translation: 公开了包含半月板组织的组合物。 例如，所公开的是包含半月板组织的组合物，其中所述半月板组织包括一个或多个工程化通道。 公开的是包含半月板组织的组合物，其包含半月板组织天然的活细胞和失活的血管。 公开了包含先前低温保存的半月板组织的组合物，其中在冷冻保存和随后解冻之后，半月板组织包含a）半月板组织天然的细胞，并且大于30％的细胞是活的，b）对半月板组织是天然的细胞外基质 c）一种或多种对半月板组织天然的生长因子，和d）一种或多种类型的功能性免疫原性细胞的耗尽量。 还公开了生产和使用包含半月板组织的这些组合物的方法。
-
5.发明申请公开(公告)号：US20200171096A1
公开(公告)日：2020-06-04
申请号：US16694650
申请日：2019-11-25
Applicant: Osiris Therapeutics, Inc.
Inventor： Steven Michael Sinclair , Alla Danilkovitch , Malathi Sathyamoorthy , Jin-Qiang Kuang , Sandeep Dhall , Anthony John Melchiorri
Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.
-
6.发明申请公开(公告)号：US20180104282A1
公开(公告)日：2018-04-19
申请号：US15632142
申请日：2017-06-23
Applicant: Osiris Therapeutics, Inc.
Inventor： Steven Michael Sinclair , Alla Danilkovitch , Malathi Sathyamoorthy , Jin-Qiang Kuang , Sandeep Dhall , Anthony John Melchiorri
CPC classification number: A61K35/50 , A01N1/0221 , A01N1/0284 , A61F13/00 , A61K9/1682 , A61K9/19 , A61K35/32 , A61K35/36 , A61L27/3604 , A61L27/3608 , A61L27/362 , A61L27/3691
Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.
-
公开(公告)号：US10603174B2
公开(公告)日：2020-03-31
申请号：US15079867
申请日：2016-03-24
Applicant: Osiris Therapeutics, Inc.
Inventor： Alla Danilkovitch , Jinqiang Kuang , Steven Michael Sinclair
Abstract: Disclosed are compositions comprising a meniscal tissue. For example, disclosed are compositions comprising a meniscal tissue, wherein the meniscal tissue comprises one or more engineered channels. Disclosed are compositions comprising a meniscal tissue comprising viable cells native to the meniscal tissue and devitalized blood vessels. Disclosed are compositions comprising a previously cryopreserved meniscal tissue, wherein after cryopreservation and subsequent thawing the meniscal tissue comprises a) cells native to the meniscal tissue and greater than 30% of the cells are viable, b) extracellular matrix that is native to the meniscal tissue, c) one or more growth factors that are native to the meniscal tissue, and d) depleted amounts of one or more types of functional immunogenic cells. Also disclosed are methods of producing and using these compositions comprising meniscal tissue.
-
公开(公告)号：US10279974B2
公开(公告)日：2019-05-07
申请号：US14657535
申请日：2015-03-13
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Yi Duan-Arnold , Alla Danilkovitch , Alexandra Gyurdieva , Jin-Qiang Kuang , Steven Michael Sinclair
IPC: B65D77/26 , B65D65/02 , B65D85/00 , B65B5/04 , B65B55/22 , A61F2/00 , A61F15/00 , A61F2/10 , A61B90/00
Abstract: A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.027 seconds)
