公开(公告)号：US11464809B2

公开(公告)日：2022-10-11

申请号：US16840554

申请日：2020-04-06

Applicant: Osiris Therapeutics, Inc.

Inventor： Alla Danilkovitch ,  Yi Duan-Arnold ,  Matthew Moorman ,  Anne Lerch ,  Jin-Qiang Kuang

IPC: A61K35/51 ,  A61K35/50 ,  A01N1/02

Abstract: Disclosed are compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are compositions comprising a previously cryopreserved umbilical tissue, wherein after cryopreservation and subsequent thawing the umbilical tissue comprises: a) viable cells native to the umbilical tissue; b) tissue integrity of native umbilical tissue; c) one or more growth factors that are native to the umbilical tissue; and d) depleted amounts of one or more types of functional immunogenic cells. Disclosed are methods of producing compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are methods of treating damaged tissue comprising administering to the site of the damaged tissue compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels.

公开(公告)号：US10994913B2

公开(公告)日：2021-05-04

申请号：US16279413

申请日：2019-02-19

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： Yi Duan-Arnold ,  Alla Danilkovitch ,  Alexandra Gyurdieva ,  Jin-Qiang Kuang ,  Steven Michael Sinclair

IPC: B65D77/26 ,  B65D65/02 ,  B65D85/00 ,  B65B5/04 ,  B65B55/22 ,  A61F2/00 ,  A61F15/00 ,  A61F2/10 ,  A61B90/00

Abstract: A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.

公开(公告)号：USD844150S1

公开(公告)日：2019-03-26

申请号：US29587466

申请日：2016-12-13

Applicant: OSIRIS THERAPEUTICS, INC.

Designer： Yi Duan-Arnold ,  Alexandra Gyurdieva

公开(公告)号：US10279974B2

公开(公告)日：2019-05-07

申请号：US14657535

申请日：2015-03-13

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： Yi Duan-Arnold ,  Alla Danilkovitch ,  Alexandra Gyurdieva ,  Jin-Qiang Kuang ,  Steven Michael Sinclair

IPC: B65D77/26 ,  B65D65/02 ,  B65D85/00 ,  B65B5/04 ,  B65B55/22 ,  A61F2/00 ,  A61F15/00 ,  A61F2/10 ,  A61B90/00

Abstract: A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.

公开(公告)号：USD843586S1

公开(公告)日：2019-03-19

申请号：US29587462

申请日：2016-12-13

Applicant: OSIRIS THERAPEUTICS, INC.

Designer： Yi Duan-Arnold ,  Alexandra Gyurdieva

公开(公告)号：USD843587S1

公开(公告)日：2019-03-19

申请号：US29587468

申请日：2016-12-13

Applicant: OSIRIS THERAPEUTICS, INC.

Designer： Yi Duan-Arnold ,  Alexandra Gyurdieva

公开(公告)号：US20170136071A1

公开(公告)日：2017-05-18

申请号：US15274100

申请日：2016-09-23

Applicant: Osiris Therapeutics, Inc.

Inventor： Alla Danilkovitch ,  Yi Duan-Arnold ,  Matthew Moorman ,  Anne Lerch ,  Jin-Qiang Kuang

IPC: A61K35/51 ,  A01N1/02

CPC classification number: A61K35/51 ,  A01N1/021 ,  A61K35/50

Abstract: Disclosed are compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are compositions comprising a previously cryopreserved umbilical tissue, wherein after cryopreservation and subsequent thawing the umbilical tissue comprises: a) viable cells native to the umbilical tissue; b) tissue integrity of native umbilical tissue; c) one or more growth factors that are native to the umbilical tissue; and d) depleted amounts of one or more types of functional immunogenic cells. Disclosed are methods of producing compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are methods of treating damaged tissue comprising administering to the site of the damaged tissue compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels.

公开(公告)号：USD776823S1

公开(公告)日：2017-01-17

申请号：US29520402

申请日：2015-03-13

Applicant: OSIRIS THERAPEUTICS, INC.

Designer： Yi Duan-Arnold ,  Alexandra Gyurdieva