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    ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME
    46.
    发明专利
    ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME 未知

    公开(公告)号：ZA201002039B

    公开(公告)日：2015-11-25

    申请号：ZA201002039

    申请日：2010-03-23

    Applicant: PORTOLA PHARM INC

    Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  SINHA UMA ,  ANDRE PATRICK

    IPC: A61K39/00

    Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa.The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

    Antidotes for factor Xa inhibitors and methods of using the same
    47.
    发明专利
    Antidotes for factor Xa inhibitors and methods of using the same 未知

    公开(公告)号：AU2008304192B9

    公开(公告)日：2014-08-21

    申请号：AU2008304192

    申请日：2008-09-26

    Applicant: PORTOLA PHARM INC

    Inventor： SINHA UMA ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  LU GENMIN

    IPC: A61K39/00

    Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa.The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

    COMBINATION THERAPY WITH A COMPOUND ACTING AS A PLATELET ADP RECEPTOR INHIBITOR
    49.
    发明专利
    COMBINATION THERAPY WITH A COMPOUND ACTING AS A PLATELET ADP RECEPTOR INHIBITOR 未知

    公开(公告)号：NZ581324A

    公开(公告)日：2012-05-25

    申请号：NZ58132408

    申请日：2008-05-02

    Applicant: PORTOLA PHARM INC

    Inventor： CONLEY PAMELA B ,  ANDRE PATRICK ,  SINHA UMA

    IPC: A61K31/235 ,  A61K31/422 ,  A61K31/435 ,  A61K31/517 ,  A61K45/06 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00

    Abstract: Disclosed herein is the use of a first therapeutic agent of [4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2Hquinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea, or a pharmaceutically acceptable salt thereof, in the preparation of a medicament for the treatment of a condition in a mammal selected from the group consisting of acute myocardial infarction, stable angina, chronic stable angina, transient ischemic attacks, strokes, peripheral vascular disease, preeclampsia/eclampsia, deep venous thrombosis, embolism, disseminated intravascular coagulation and thrombotic cytopenic purpura, thrombotic and restenotic complications following invasive procedures resulting from angioplasty, carotid endarterectomy, post CABG (coronary arteryl bypass graft) surgery, vascular graft surgery, stent placements and insertion of endovascular devices and prosthesis, wherein the medicament is for administration in combination with a second therapeutic agent which is selected from the group consisting of betrixaban, a specific inhibitor of factor IXa, a specific inhibitor of factor XI, a specific inhibitor of factor XIa, a specific inhibitor of factor VIIa, YM-150, Daiichi DU-176b, N-{ (1R)-2-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxo-1-phenylethyl} -1H-indole-6-carboxamede, apixaban, rivaroxaban, otamixaban, razaxaban, AZD0837, RB2006, ximelagatran, dabigatran, bivalirudin, argatroban, phenocoumarol, synthetic pentasaccharides, such as fondaparinux, idraparinux, biotinylated idraparinux; abciximab, eptifibatide, tirofiban, dipyridamole, Aggrenox, cilostazol, ifetroban, isogrel, furegrelate, resveratrol, ozagrel, an anticoagulant agent and an antiplatelet agent.

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