公开(公告)号：AU2013375294B2

公开(公告)日：2018-08-09

申请号：AU2013375294

申请日：2013-03-13

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA ,  KARBARZ MARK ,  PANDEY ANJALI ,  CONLEY PAMELA B

IPC: C07K14/745 ,  A61K38/48 ,  C12N9/64

Abstract: The present disclosure relates to compositions and methods for the treatment of bleeding disorders, such as hemophilia A, hemophilia B, von Willebrand (vWF) disease, and factor XII deficiency, by reducing the circulating concentration of tissue factor pathway inhibitor (TFPI), with a factor Xa derivative.

公开(公告)号：ES2612458T3

公开(公告)日：2017-05-17

申请号：ES13732317

申请日：2013-06-12

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA

IPC: C07K1/22 ,  C12N9/64

Abstract: Un procedimiento de purificación de una serina proteasa, que comprende: cargar la serina proteasa en un cromatógrafo de afinidad basado en inhibidor de tripsina de soja (STI), y eluir la serina proteasa con un tampón de elución que comprende arginina que interrumpe la interacción entre el STI y la serina proteasa.

公开(公告)号：AU2017200212A1

公开(公告)日：2017-02-02

申请号：AU2017200212

申请日：2017-01-12

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61P7/02 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/715 ,  A61K31/727 ,  A61K38/36 ,  A61K38/48 ,  A61K39/00 ,  A61K39/395 ,  A61P7/04 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N5/10 ,  C12N9/64 ,  C12P21/00

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or 5 have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

公开(公告)号：SI2193196T1

公开(公告)日：2017-01-31

申请号：SI200831678

申请日：2008-09-26

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61K38/00 ,  A61K39/00 ,  A61P7/00 ,  C12N9/00

公开(公告)号：HK1217657A1

公开(公告)日：2017-01-20

申请号：HK16105784

申请日：2016-05-20

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA ,  KARBARZ MARK ,  PANDEY ANJALI ,  CONLEY PAMELA B

IPC: A61K20060101 ,  C07K20060101 ,  C12N20060101

公开(公告)号：HK1209760A1

公开(公告)日：2016-04-08

申请号：HK15110322

申请日：2015-10-20

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA

IPC: C07K20060101 ,  C12N20060101

Abstract: Disclosed herein are methods and kits for purifying a serine protease. The methods entail loading the serine protease to a soybean trypsin inhibitor (STI) based affinity chromatograph, and eluting the serine protease with an elution buffer comprising an agent that disrupts interaction between the STI and the serine protease.

公开(公告)号：HK1205188A1

公开(公告)日：2015-12-11

申请号：HK15105733

申请日：2015-06-16

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  CONLEY PAMELA B ,  SINHA UMA

IPC: C12N20060101

Abstract: Disclosed are methods and isolated cells useful for the improved production of function fXa derivative protein that acts as a fXa inhibitor antidote. One aspect relates to an isolated cell comprising the r-Antidote polynucleotide and Furin polynucleotide. Another aspect relates to a method for preparing the cleaved two-chain r-Antidote by expressing, in a cell, the pre-processed r-Antidote polypeptide and a Furin polypeptide.

公开(公告)号：AU2013274288A1

公开(公告)日：2015-01-15

申请号：AU2013274288

申请日：2013-06-12

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA

IPC: C07K1/22 ,  C12N9/64

Abstract: Disclosed herein are methods and kits for purifying a serine protease. The methods entail loading the serine protease to a soybean trypsin inhibitor (STI) based affinity chromatograph, and eluting the serine protease with an elution buffer comprising an agent that disrupts interaction between the STI and the serine protease

公开(公告)号：CA2876361A1

公开(公告)日：2013-12-19

申请号：CA2876361

申请日：2013-06-12

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA

IPC: C07K1/22 ,  C12N9/64

Abstract: Disclosed herein are methods and kits for purifying a serine protease. The methods entail loading the serine protease to a soybean trypsin inhibitor (STI) based affinity chromatograph, and eluting the serine protease with an elution buffer comprising an agent that disrupts interaction between the STI and the serine protease

公开(公告)号：AU2013205326A8

公开(公告)日：2013-06-06

申请号：AU2013205326

申请日：2013-04-11

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61P7/02 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/715 ,  A61K31/727 ,  A61K38/36 ,  A61K38/48 ,  A61K39/00 ,  A61K39/395 ,  A61K47/48 ,  A61P7/04 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N5/10 ,  C12N9/64 ,  C12P21/00

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or 5 have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.