公开(公告)号：NO20091779L

公开(公告)日：2009-05-06

申请号：NO20091779

申请日：2009-05-06

Applicant: SERVIER LAB

Inventor： AUDINOT VALERIE ,  BOUTIN JEAN ALBERT ,  MARCHAND PASCAL ,  BADONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

IPC: C07D209/32

Abstract: Indole derivatives (I), their enantiomers, diastereomers and their acid/base addition salts are new. Indole derivatives of formula (I), their enantiomers, diastereomers and their acid/base addition salts are new. R 11-6C alkyl, 3-8C cycloalkyl or 3-8C cycloalkyl-1-6C alkyl, preferably alkyl; NR 2R 35-8 membered heterocycle, preferably piperidinyl; and n : 2-6, preferably 2. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen; Gastrointestinal-Gen; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Endocrine-Gen; Contraceptive; Immunomodulator; Cytostatic. MECHANISM OF ACTION : Melatonin receptor binder. The affinity of (I) to bind with melatonin receptors MT1 and MT2 was tested using 2-[ 1> 2> 5>I]-iodomelatonin as reference radioligand. The results showed that (I) exhibited an inhibition constant value of less than 1 mu M.

公开(公告)号：MX2009004007A

公开(公告)日：2009-04-27

申请号：MX2009004007

申请日：2007-10-17

Applicant: SERVIER LAB

Inventor： CAIGNARD DANIEL-HENRI ,  DELAGRANGE PHILIPPE ,  AUDINOT VALERIE ,  MARCHAND PASCAL ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  BABONNEAU VINCET

IPC: A61K31/404 ,  C07D209/42 ,  A61P1/00 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

Abstract: Los compuestos de la fórmula (I), en la cual: R1 es un grupo alquilo, cicloalquilo o cicloalquilalquilo; R2 es un grupo alquilo (C1-C6), lineal o ramificado; y n es 1 a 6; medicamentos.

公开(公告)号：HK1078566A1

公开(公告)日：2006-03-17

申请号：HK05110489

申请日：2005-11-21

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  BAUT GUILLAUME LE ,  PFEIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: C07C20060101 ,  A61K20060101 ,  A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P20060101 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D20060101 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：MA27103A1

公开(公告)日：2004-12-20

申请号：MA27795

申请日：2004-07-21

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  LE BAUT GUILLAUME ,  PFEIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

Abstract: NOUVEAUX DERIVES DE 3-ARYL-2,5-DIHYDROXY-1,4-BENZOQUINONES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT Composé de formule (I): dans laquelle : R1 et R2, identiques ou différents, représentent chacun un atome d'hydrogène ou un groupement acyle ou alkyle, Ar représente un groupement aryle ou hétéroaryle, A représente un groupement choisi parmi: R4 représente un atome d'hydrogène ou un groupement alkyle, R5 représente un atome d'hydrogène ou un groupement choisi parmi alkyle, aryle et hétéroaryle, R3 représente un groupement aryle, hétéroaryle, dicyclopropylméthyle ou benzhydryle, ou A-R3 représente un groupement naphtyle éventuellement substitué, à l'exclusion de la 2,5-dihydroxy-3-(4-méthoxyphényl)-6-(2-phényléthényl)-1,4-benzoquinone, de la 2,5-dihydroxy-3-(4-méthoxyphényl)-6-(2-naphtyl)-1,4-benzoquinone, et de la 2,5-dihydroxy-3-(2-naphtyl)-6-phényl-1,4-benzoquinone. Médicaments.

公开(公告)号：AU774563B2

公开(公告)日：2004-07-01

申请号：AU2689001

申请日：2000-12-21

Applicant: SERVIER LAB

Inventor： DUFLOS MURIEL ,  ROBERT JEAN-MICHEL ,  NOURRISSON MARIE-RENEE ,  BAUT GUILLAUME LE ,  CAIGNARD DANIEL-HENRI ,  BIZOT-ESPIARD JEAN-GUY ,  RENARD PIERRE

IPC: C07D213/74 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D409/14 ,  C07D417/14

Abstract: Compound of formula (I):wherein:Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl,A represents a bond or linear or branched (C1-C6)alkylene,its optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid.

公开(公告)号：SI1240162T1

公开(公告)日：2003-10-31

申请号：SI200030098

申请日：2000-12-21

Applicant: SERVIER LAB

Inventor： DUFLOS MURIEL ,  ROBERT JEAN-MICHEL ,  NOURRISSON MARIE-RENEE ,  LE BAUT GUILLAUME ,  CAIGNARD DANIEL-HENRI ,  BIZOT-ESPIARD JEAN-GUY ,  RENARD PIERRE

IPC: C07D409/14

公开(公告)号：NZ519144A

公开(公告)日：2003-10-31

申请号：NZ51914400

申请日：2000-12-21

Applicant: SERVIER LAB

Inventor： DUFLOS MURIEL ,  ROBERT JEAN-MICHEL ,  NOURRISSON MARIE-RENEE ,  LE BAUT GUILLAUME ,  CAIGNARD DANIEL-HENRI ,  BIZOT-ESPIARD JEAN-GUY ,  RENARD PIERRE

IPC: C07D213/74 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D409/14 ,  C07D417/14 ,  A61B ,  A61

Abstract: Described is a compound of formula (I), wherein: Het1 and Het2, which may be identical or different, each represents a heteroaryl group, A represents a bond or a linear or branched (C1-C6)alkylene group, their optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid. Also described is a pharmaceutical composition comprising the compound of formula (I). The compounds of formula (I) are useful for treating inflammatory conditions such as psoriasis.

公开(公告)号：PT1240162E

公开(公告)日：2003-08-29

申请号：PT00990091

申请日：2000-12-21

Applicant: SERVIER LAB

Inventor： BAUT GUILLAUME LE ,  ROBERT JEAN-MICHEL ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE ,  DUFLOS MURIEL ,  NOURRISSON MARIE-RENEE ,  BIZOT-ESPIARD JEAN-GUY

IPC: C07D213/74 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D409/14 ,  C07D417/14

Abstract: Compound of formula (I):wherein:Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl,A represents a bond or linear or branched (C1-C6)alkylene,its optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid.

公开(公告)号：AT240322T

公开(公告)日：2003-05-15

申请号：AT00990091

申请日：2000-12-21

Applicant: SERVIER LAB

Inventor： DUFLOS MURIEL ,  ROBERT JEAN-MICHEL ,  NOURRISSON MARIE-RENEE ,  LE BAUT GUILLAUME ,  CAIGNARD DANIEL-HENRI ,  BIZOT-ESPIARD JEAN-GUY ,  RENARD PIERRE

IPC: C07D213/74 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D409/14 ,  C07D417/14

Abstract: Compound of formula (I):wherein:Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl,A represents a bond or linear or branched (C1-C6)alkylene,its optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid.

公开(公告)号：NO20023023L

公开(公告)日：2002-06-21

申请号：NO20023023

申请日：2002-06-21

Applicant: SERVIER LAB

Inventor： DUFLOS MURIEL ,  ROBERT JEAN-MICHEL ,  NOURRISSON MARIE-RENEE ,  BAUT GUILLAUME LE ,  CAIGNARD DANIEL-HENRI ,  BIZOT-ESPIARD JEAN-GUY ,  RENARD PIERRE

IPC: C07D213/74 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D409/14 ,  C07D417/14 ,  A61K31/385

Abstract: Compound of formula (I):wherein:Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl,A represents a bond or linear or branched (C1-C6)alkylene,its optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid.