公开(公告)号：CA2609726C

公开(公告)日：2013-10-01

申请号：CA2609726

申请日：2006-05-24

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  KOSKIMIES PASI ,  KALLIO LILA ,  WESKE MICHAEL

IPC: C07J41/00 ,  A61K31/565 ,  A61K31/58 ,  A61P5/32 ,  C07J43/00 ,  C07J71/00

Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17.beta.-hydroxysteroid dehydrogenase type I (17.beta.-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17.beta.-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17.beta.-estradiol concentration.

公开(公告)号：SK287607B6

公开(公告)日：2011-03-04

申请号：SK612003

申请日：2001-07-12

Applicant: SOLVAY PHARM GMBH

Inventor： HEBEBRAND JOHANNES ,  ANTEL JOCHEN ,  PREUSCHOFF ULF ,  DAVID SAMUEL ,  SANN HOLGER ,  WESKE MICHAEL

IPC: A61P1/00 ,  G01N33/50 ,  A61K45/00 ,  A61P3/04 ,  C12Q1/02 ,  C12Q1/527 ,  G01N33/15

Abstract: The method for locating compounds which are suitable for the treatment and/or prophylaxis of obesity, whereby the ability of the examined compounds to inhibit de novo lipogenase in mammals and/or humans is determined. Also disclosed is the use of compounds which are capable of inhibiting de novo lipogenase in mammals in the production of medicaments for the treatment and/or prophylaxis of obesity.

公开(公告)号：BRPI0610559A2

公开(公告)日：2010-06-29

申请号：BRPI0610559

申请日：2006-04-11

Applicant: SOLVAY PHARM GMBH

Inventor： MOLONEY BRIAN ,  MARRISON LESTER ,  ZIEGLER DIETER ,  MLINARIC MICHAEL ,  BOECKER CHRISTIANE ,  WESKE MICHAEL ,  WITTE KLAUS ,  FISCHER YVAN ,  BRUECKNER REINHARD

IPC: C07D311/68 ,  A61K31/353 ,  A61K31/4025 ,  A61K31/453 ,  A61K31/497 ,  A61K31/5355 ,  A61P9/00 ,  C07D405/12 ,  C07D413/12

Abstract: Cardiovascular active compounds of the general formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and n have the meanings given in the description, and also a process for the preparation of these compounds and intermediate products of this process are described. Furthermore, pharmaceutical compositions comprising the compounds of Formula (I) are specified.

公开(公告)号：PL1678130T3

公开(公告)日：2009-01-30

申请号：PL04817204

申请日：2004-10-14

Applicant: SOLVAY PHARM GMBH

Inventor： SYKES DAVID ,  MOLONEY BRIAN ,  MARRISON LESTER ,  ZIEGLER DIETER ,  MLINARIC MICHAEL ,  BOECKER CHRISTIANE ,  BRUECKNER REINHARD ,  WESKE MICHAEL ,  WITTE KLAUS ,  FISCHER YVAN

IPC: C07D201/00 ,  A61K31/353 ,  C07D311/68 ,  C07D407/12

公开(公告)号：DK1678130T3

公开(公告)日：2008-12-01

申请号：DK04817204

申请日：2004-10-14

Applicant: SOLVAY PHARM GMBH

Inventor： SYKES DAVID ,  MOLONEY BRIAN ,  MARRISON LESTER ,  ZIEGLER DIETER ,  MLINARIC MICHAEL ,  BOECKER CHRISTIANE ,  BRUECKNER REINHARD ,  WESKE MICHAEL ,  WITTE KLAUS ,  FISCHER YVAN

IPC: C07D201/00 ,  A61K31/353 ,  C07D311/68 ,  C07D407/12

Abstract: The invention relates to compounds of general formula (I), wherein the meaning of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is given in a description, to a method for producing said compounds and to intermediate products thereof. Drugs containing the inventive compounds of formula (1) are also disclosed.

公开(公告)号：UA82907C2

公开(公告)日：2008-05-26

申请号：UAA200605330

申请日：2004-10-14

Applicant: SOLVAY PHARM GMBH

Inventor： ZIEGLER DIETER ,  BRUCKNER REINHARD ,  WESKE MICHAEL

IPC: A61K31/353 ,  A61P9/06 ,  C07D311/68 ,  C07D407/12

Abstract: The invention relates to compounds of general formula (I), wherein the meaning of R1, R2, R3, R4, R5 and R6 is given in a description, to a method for producing said compounds and to intermediate products thereof. Drugs containing the inventive compounds of formula (1) are also disclosed. I

公开(公告)号：HK1096105A1

公开(公告)日：2007-05-25

申请号：HK07103455

申请日：2007-03-30

Applicant: SOLVAY PHARM GMBH

Inventor： HOELTJE DAGMAR ,  FISCHER YVAN ,  ZIEGLER DIETER ,  WESKE MICHAEL ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  MESSINGER JOSEF ,  PAHL AXEL ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI ,  TURSKI LECHOSLAW

IPC: A61K20090101 ,  A61K38/00 ,  A61P20090101 ,  A61P9/12 ,  C07K20090101 ,  C07K5/02 ,  C07K5/078

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：NO20061821A

公开(公告)日：2006-06-22

申请号：NO20061821

申请日：2006-04-25

Applicant: SOLVAY PHARM GMBH

Inventor： TURSKI LECHOSLAW ,  ZIEGLER DIETER ,  MESSINGER JOSEF ,  WESKE MICHAEL ,  PAHL AXEL ,  HOELTJE DAGMAR ,  FISCHER YVAN ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078

CPC classification number: C07K5/06139 ,  A61K38/00 ,  C07K5/0222 ,  Y02A50/409

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：AU2001277534B9

公开(公告)日：2006-02-23

申请号：AU2001277534

申请日：2001-07-12

Applicant: SOLVAY PHARM GMBH

Inventor： PREUSCHOFF ULF ,  WESKE MICHAEL ,  SANN HOLGER ,  HEBEBRAND JOHANNES ,  ANTEL JOCHEN ,  DAVID SAMUEL

IPC: A61P1/00 ,  G01N33/50 ,  A61K45/00 ,  A61P3/04 ,  C12Q1/02 ,  C12Q1/527 ,  G01N33/15

Abstract: Compounds for the treatment and/or prevention of obesity are selected on the basis of their capability to inhibit de novo lipogenesis in mammals. An independent claim is also included for the use of compounds which are capable of inhibiting de novo lipogenesis in mammals and which have no anticonvulsant activity for the production of a medicament for the treatment and/or prevention of obesity. - ACTIVITY : Anorectic. - MECHANISM OF ACTION : Lipogenesis inhibitor; Carboanhydrase inhibitor. No biological data given.

公开(公告)号：CA2539895A1

公开(公告)日：2005-04-07

申请号：CA2539895

申请日：2004-09-23

Applicant: SOLVAY PHARM GMBH

Inventor： FISCHER YVAN ,  MICHAELIS KATHRIN ,  TURSKI LECHOSLAW ,  IKONOMIDOU HRISSANTHI ,  HOELTJE DAGMAR ,  PAHL AXEL ,  MESSINGER JOSEF ,  KARIMI-NEJAD YASMIN ,  HOEFER CONSTANZE ,  WESKE MICHAEL ,  ZIEGLER DIETER

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.