公开(公告)号：JP2009257777A

公开(公告)日：2009-11-05

申请号：JP2008103759

申请日：2008-04-11

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： ODA ICHIRO ,  YAJIMA ATSUSHI ,  HASHIZUME KENTARO ,  TSUNASAWA YOSHIO

IPC: G01N21/64

Abstract: PROBLEM TO BE SOLVED: To provide a fluorescence imaging device for imaging in a condition corresponding to a position of a portion to be measured in a biosample.
SOLUTION: An imaging part 2 includes a two-dimensional detector or an optical system for guiding light of an image of the biosample 4 into the two-dimensional detector. A light source device 6 irradiates excitation light selectively from a plurality of mutually different directions to the biosample 4. An imaging operation of the imaging part 2 or a light irradiation operation of the light source device 6 is controlled by a control part 8. An imaging condition setting part 14 for setting an observation direction in which imaging is performed by an operator or an irradiation direction of the excitation light as an imaging condition is provided. The control part 8 controls the imaging part 2 or the light source device 6 so that imaging is performed in the imaging condition set by the imaging condition setting part 14.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于在与生物样品中待测量部分的位置相对应的条件下成像的荧光成像装置。 解决方案：成像部件2包括用于将生物样品4的图像的光引导到二维检测器中的二维检测器或光学系统。 光源装置6从多个相互不同的方向选择性地将激发光照射到生物样品4.成像部2的成像操作或光源装置6的光照射操作由控制部8控制。成像 提供用于设置由操作者进行成像的观察方向的条件设定部14或作为成像条件的激发光的照射方向。 控制部分8控制成像部分2或光源装置6，以便在由成像条件设置部分14设置的成像条件下执行成像。（C）2010，JPO＆INPIT

公开(公告)号：JP2009229290A

公开(公告)日：2009-10-08

申请号：JP2008075997

申请日：2008-03-24

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： YAJIMA ATSUSHI ,  HIZUME KENTARO ,  ODA ICHIRO ,  TSUNASAWA YOSHIO

IPC: G01N21/01 ,  A61B10/00 ,  G01N21/17 ,  G01N21/64 ,  G03B15/00

Abstract: PROBLEM TO BE SOLVED: To provide a biological image acquisition apparatus capable of performing multi-directional and simultaneous observations and measurements in a short time and to provide a sample holding apparatus for implementing the biological image acquisition apparatus. SOLUTION: A sample holding member 2 is supported by a supporting mechanism 12. The supporting mechanism 12 supports a pair of opposed end parts of the sample holding member 2. Gaps 14 are provided between unsupported end parts of the sample holding member 2 and the supporting mechanism 12. The gaps 14 are light-passing regions for passing reflected light from reflecting mirrors M3 and M4 on the back side of the sample holding member 2. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 解决的问题：提供能够在短时间内执行多方向同时观测和测量并提供用于实施生物图像获取装置的样本保持装置的生物图像获取装置。 解决方案：样品保持构件2由支撑机构12支撑。支撑机构12支撑样品保持构件2的一对相对端部。间隙14设置在样品保持构件2的未支撑的端部之间 间隙14是用于使来自反射镜M3和M4的反射光通过样品保持构件2背面的光通过区域。（C）2010，JPO＆INPIT

公开(公告)号：JP2001153794A

公开(公告)日：2001-06-08

申请号：JP33390899

申请日：1999-11-25

Applicant: SHIMADZU CORP

Inventor： KOBAYASHI MANAMI ,  ITO YASUNOBU ,  KONISHI IKUO ,  TSUNASAWA YOSHIO ,  TAMAI TETSUO

IPC: A61B5/145 ,  A61B5/1455 ,  G01N21/17

Abstract: PROBLEM TO BE SOLVED: To obtain clear distribution images of living body tissues by adding a position at a living body of the distribution image and removing a density distribution by a surface distribution image. SOLUTION: The apparatus irradiates the living body with a light, detects a light emitted from the living body by a two-dimensional detector and obtains information on the living body with the use of detected images. For additionally constituting a function of adding supplementary image data to distribution image data related to tissues of the living body, there are provided an image- measuring means 2 for measuring two-dimensional image data of the living body including wavelength image data by a plurality of measurement wavelengths, a distribution image-forming means 4 for calculating the distribution image data related to the tissues of the living body from the plurality of wavelength image data, a supplementary image-forming means 5 for forming the supplementary image data to supplement the distribution image from the two-dimensional image data, and an image-operating means 6 for operating the supplementary image data and the distribution image data, thereby calculating supplemented distribution image data.

公开(公告)号：JP2001149348A

公开(公告)日：2001-06-05

申请号：JP33418599

申请日：1999-11-25

Applicant: SHIMADZU CORP

Inventor： KONISHI IKUO ,  TSUNASAWA YOSHIO ,  KOBAYASHI MANAMI ,  ITO YASUNOBU ,  TAMAI TETSUO

IPC: A61B5/145 ,  A61B5/1455 ,  G01N21/17

Abstract: PROBLEM TO BE SOLVED: To obtain a clear distribution image of an organismic tissue by removing influence by shade and shadow in an optical measuring device for a organism. SOLUTION: Only distribution image data on an organismic tissue is extracted by removing an image component by shade and shadow from plural wave length image data detected by a two-dimensional detector to obtain a clear distibution image. A first mode forms reference image data having only shade/shadow information on a subject, corrects measuring image data by this reference image data, and takes out only object distribution image data. A second mode measures the subject in the plural image pickup directions or the illuminating direction, and calculates the distribution image data by correcting a shade/ shadow component by reconstituting obtained plural image data.

公开(公告)号：JP2001013063A

公开(公告)日：2001-01-19

申请号：JP18773799

申请日：1999-07-01

Applicant: SHIMADZU CORP

Inventor： TSUNASAWA YOSHIO ,  ODA ICHIRO ,  TAKEUCHI SADAO ,  ITO YASUNOBU ,  SAKAUCHI HISAFUMI ,  KOBAYASHI MANAMI ,  HARADA TAKAHIRO

IPC: A61B5/145 ,  A61B5/1455 ,  G01N21/17

Abstract: PROBLEM TO BE SOLVED: To obtain a photometric apparatus in which the position and the combination of light sending points and/or light receiving points operated simultaneously in the measurement of a plurality of parts on a specimen are changed without changing the connection of a light source of a wiring, of which measuring time is shortened and of which S/N ratio is enhanced. SOLUTION: In this photometric apparatus, a specimen 10 is irradiated with light, and light which is emitted to the outside after being transmitted through the specimen and/or after being reflected by the specimen is measured. The photometric apparatus is constituted in such a way that it is provided with a light sending and receiving part 11 which is provided with a plurality of light sending parts 12 used to shine the light at the specimen and which is provided with a plurality of light receiving parts 13 used to receive the emitted light and that it is provided with a computing and control part which controls the sending and receiving operation of the light with reference to the light sending and receiving parts 11. The computing and control part is provided with a plurality of control tables which decide the combination and the order of the light sending parts and/or the light receiving parts used to perform the sending and receiving operation of the light, and it controls the sending and receiving operation of the light according to the combination and the order of the light sending parts and/or the light receiving parts in the selected control tables.

公开(公告)号：JPH0678942B2

公开(公告)日：1994-10-05

申请号：JP31326086

申请日：1986-12-29

Applicant: SHIMADZU CORP

Inventor： TSUNASAWA YOSHIO ,  GOTO SEIJI ,  SATO TATSUMI

IPC: G01J3/18

公开(公告)号：JPH0484959A

公开(公告)日：1992-03-18

申请号：JP19986090

申请日：1990-07-27

Applicant: SHIMADZU CORP

Inventor： TSUNASAWA YOSHIO ,  TAMURA TOMOMI ,  EDA HIDEO

IPC: A61B10/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/01

Abstract: PURPOSE:To constitute the standard so that it has the same transmission characteristic as a biological body, has the same light attenuation factor as a target sample and scarcely causes time aging, and the absorbance measuring origin which does not depend on a patient is derived by providing a light input part and a light output part consisting of a light scattering body, and a coupling part of both the parts having an extinction function. CONSTITUTION:When a light input part 2 in which the inside of a spherical body is painted in white is irradiated with light from a light sending side light guide 4, an irradiated light 6 is scattered on the inside surface of the spherical body. A light output part 8 also consists of a spherical body of the same size, its inside is painted in white, and a diffused light 12 scattered in the inside concerned is made incident on a light receiving side light guide 10. Between both parts 2, 8, a cylindrical coupling part 14 is provided, extinction partition plates 16, 18 are inserted, and a hole for controlling the degree of extinction is made on the partition plates 16,18. In such a way, since light radiated to a patient is diffusive, and also, the light input part 2 and the light output part 8 consist of a light scattering body, the irradiated light having an ununiform angle distribution is also averaged and becomes the prescribed degree of extinction, and sent to the light receiving side from the output part 2. In this case, in order to obtain the degree of extinction being near a measured sample, the coupling part 14 is adjusted by executing the adjustment by a size and the number of holes of the coupling part 14.

公开(公告)号：JPH03202773A

公开(公告)日：1991-09-04

申请号：JP34237389

申请日：1989-12-29

Applicant: SHIMADZU CORP

Inventor： TSUNASAWA YOSHIO ,  TAMAI TETSUO

IPC: G01N35/10

Abstract: PURPOSE:To prevent the mutual contamination between reagents and to simplify an apparatus by mounting tips to a pipetting nozzle sucking and emitting reagents with respect to a plurality of reagents at ever reagent bottles to use the same in common. CONSTITUTION:Reagent bottles 55a - 55h and tip holders 56 are mounted on a reagent table 54 by the number of reagents. At first, the table 54 is rotated so as to bring the indicated reagent to the place directly under a nozzle 51 and the nozzle 51 falls to be inserted in a chip 53. Next, the nozzle 51 rises and falls and the reagent is collected in the tip 53 by a syringe 52. Thereafter the nozzle 51 rises and the arm of a pipetting nozzle mechanism 50 is rotated toward a reaction line and the reagent is pipetted to reaction tubes 4. After pipetting the tip 53 is returned to the original position of the tip holder 56. Next, the pawl 60 of a tip removing apparatus 58 is moved to become the state grasping the nozzle 51 and the nozzle 51 rises in this state and the chip 53 is left in the holder 56 to complete one cycle of the pipetting of the reagent. By this method, the mutual contamination between reagents can be prevented.

公开(公告)号：JPH03188356A

公开(公告)日：1991-08-16

申请号：JP32893589

申请日：1989-12-18

Applicant: SHIMADZU CORP

Inventor： TSUNASAWA YOSHIO

IPC: G01N33/53 ,  G01N21/75 ,  G01N21/77 ,  G01N33/536

Abstract: PURPOSE:To correct the error caused by dilution by using two kinds of raw liquids of standard solutions having the compositions close to a sample, and preparing the calibrating liquids in multiple stages. CONSTITUTION:First raw liquid of standard solution 52 and second raw liquid of standard solution 54 are prepared for each item. Then, the number of the raw liquids of standard solutions is (item-number X 2) even if calibrating liquids for multiple stages are prepared for each item. The first raw liquid of standard solution 52 is commonly used for each item, and the second raw liquid of standard solution 54 is prepared for each item. Then, the number of the raw liquids of standard solutions to be prepared is (item-number + 1) even if the calibrating liquids in multiple stages are prepared. When the concentration of the calibrating liquid which is obtained by mixing the first and second raw liquids of standard solutions 52 and 54 is made to be an effective value, a matrix effect can be incorporated in the effective value.

公开(公告)号：JPH03156372A

公开(公告)日：1991-07-04

申请号：JP34237589

申请日：1989-12-29

Applicant: SHIMADZU CORP

Inventor： TSUNASAWA YOSHIO ,  TAMAI TETSUO

IPC: G01N35/02 ,  G01N33/543

Abstract: PURPOSE:To realize a random access system by feeding a reaction tube to a reaction line for every measuring item through a reaction tube feeder. CONSTITUTION:A reaction tube feeder 6 successively feeds reaction tubes 4 of selected measuring items to a reaction line one at a time and the position where the reaction tubes 6 is fed is set as a start point. At first, the reaction tube 4 of an indicated item is inserted in the reaction tube holder of the line 2 from the feeder 6 and a specimen is distributed to the reaction tube 4 in a specimen distribution part 8 while a diluent and an enzyme standard solution are distributed to the reaction tube 4 in a reagent distribution part 10. Thereafter, antigen-antibody reaction is carried out for 43min before reaching a washing mechanism 12 and the reaction tube 4 is washed by the mechanism 12. Further, a substrate solution is distributed in a substrate solution distribution part 14 and color reaction is carried out for 16min until absorbancy is measured in an absorbancy measuring part 16 and absorbancy is measured in the absorbancy measuring part 16. Thereafter, the residual solution is disposed and the reaction tube 4 is discharged. In this one-step method, one analysis is completed within 60min of one round.