公开(公告)号：JPH11246482A

公开(公告)日：1999-09-14

申请号：JP5303498

申请日：1998-03-05

Applicant: TORAY INDUSTRIES

Inventor： ONO TAKAE ,  IMAMURA SHINZO

IPC: B01J27/06 ,  C07B61/00 ,  C07C67/313 ,  C07C69/716

Abstract: PROBLEM TO BE SOLVED: To readily obtain the subject compound useful for an agrochemical, etc., in a high yield without a specific apparatus and without light irradiation, by oxidizing an α-hydroxycarboxylic acid with hydrogen peroxide in a specific solvent in the presence of a bromine catalyst at a prescribed temperature. SOLUTION: (A) A compound of the formula [R is a (cyclo)alkyl, a (substituted) aryl or an aralkyl; R is a 1-4C alkyl] is oxidized with (D) hydrogen peroxide in (B) a water-immiscible solvent (e.g. an aliphatic or aromatic hydrocarbon) in the presence of (C) bromine or hydrogen bromide at 30 deg.C (preferably 30-80 deg.C). Preferably the reaction is carried out by using 0.05-0.4 time mol of the component C and 0.7-1.5 times mol of the component D based on 1 mol of the component A, feeding the components B and C, heating the components to a fixed temperature, feeding 10% of the component A, then supplying the component A and the component D for 1-3 hours so as to approximately simultaneously finish the supply and aging the reaction product to complete the reaction.

公开(公告)号：JPH11228480A

公开(公告)日：1999-08-24

申请号：JP5582798

申请日：1998-02-20

Applicant: SODA AROMATIC ,  TORAY INDUSTRIES

Inventor： TAKAOKA HIDEAKI ,  ITO NOBUHIKO ,  HASEBE AKIO ,  MURAOKA HIDEO ,  IMAMURA SHINZO

IPC: C07C45/81 ,  C07C49/17 ,  C07C51/43 ,  C07C55/02 ,  C07C55/18 ,  C07C55/20 ,  C07C55/21 ,  C07C59/215

Abstract: PROBLEM TO BE SOLVED: To separate and recover the subject compounds useful as an important intermediate of a perfume by selectively crystallizing out an alkali metal salt of ω-hydroxy-(ω-3)-ketofatty acid from a mixture containing an alkali metal salt of a long chain dicarboxylic acid, and then performing a solid-liquid separation. SOLUTION: This alkali metal salt of ω-hydroxy-(ω-3)-ketofatty acid of formula I [(k) is 9-13 integer; M is an alkali metal], useful as an important intermediate of a large cyclic lactone-based perfume, is separated and recovered by selectively crystallizing the compound of formula I from a mixture containing the compound of formula I and an alkali metal salt of a long chain dicarboxylic acid of formula II [(m) is 9-13 integer], and then performing a solid liquid separation to a cake and a filtrate liquid.

公开(公告)号：JP2507465B2

公开(公告)日：1996-06-12

申请号：JP20994987

申请日：1987-08-24

Applicant: TORAY INDUSTRIES

Inventor： SATO HARUYO ,  ITO NORIKO ,  IMAMURA SHINZO

IPC: C12P41/00 ,  C12R1/01 ,  C12R1/05 ,  C12R1/185 ,  C12R1/20 ,  C12R1/38 ,  C12R1/40 ,  C12R1/425 ,  C12R1/645 ,  C12R1/72 ,  C12R1/78 ,  C12R1/84 ,  C12R1/88

公开(公告)号：JPH06178691A

公开(公告)日：1994-06-28

申请号：JP33463592

申请日：1992-12-15

Applicant: TORAY INDUSTRIES

Inventor： MIYATA REIKO ,  YONEHARA TORU ,  IMAMURA SHINZO

IPC: C12P7/22 ,  C12R1/01 ,  C12R1/06 ,  C12R1/13 ,  C12R1/15 ,  C12R1/365 ,  C12R1/465 ,  C12R1/645 ,  C12R1/72 ,  C12R1/78 ,  C12R1/84 ,  C12R1/85 ,  C12R1/88

Abstract: PURPOSE:To profitably obtain the subject compound useful as a raw material for medicines, etc., by treating 2,2,2-trihalogenoacetophenone with a microorganism belonging to the genus Apiotrichum, etc., and having an ability to convert the 2,2,2-trihalogenoacetophenone into the optically active alcohol. CONSTITUTION:2,2,2-Trihalogenoacetophenone is treated with a microorganism belonging to the genus Apiotricbmt, Candida, Torulopsis, Rhodotorula, Trichosporon, Rhodosporidium, Pichia, Hansenula, Saccharomyces, Klebsiella, Rhodococcus, Microbacterium, Brevibacterium, Corynebacterium, Arthrobacter, Enterobacter, Amycolasetopsis, Streptomyces, Nocardioides, etc., its treated product or its cultured product, followed by isolating the treating product from the reaction solution to provide the objective optically active compound.

公开(公告)号：JPH0247471B2

公开(公告)日：1990-10-19

申请号：JP3993381

申请日：1981-03-19

Applicant: TORAY INDUSTRIES

Inventor： SATO HARUYO ,  IMAMURA SHINZO

IPC: C08K5/00 ,  C07D207/267 ,  C07D487/08 ,  C08K5/36 ,  C08L21/00

公开(公告)号：JPH0269490A

公开(公告)日：1990-03-08

申请号：JP22061688

申请日：1988-09-02

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASATO ,  HANADA SATORU

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07C211/65 ,  C07F15/00

Abstract: NEW MATERIAL:The compound of formula I. USE:A remedy for malignant tumor. PREPARATION:The objective compound can be produced by reacting a dinitrato(1,2-diaminocyclohexane)platinum(II) or disulfato(1,2-diaminocyclohexane)platinum(II) of formula II [R is (ONO2)2 or OSO3] with a compound of formula IV in the presence of an alkali metal or alkaline-earth metal hydroxide or reacting dihydroxo-(1,2-diaminocyclohexane)platinum(II) of formula III with the compound of formula IV.

公开(公告)号：JPH01272592A

公开(公告)日：1989-10-31

申请号：JP10193888

申请日：1988-04-25

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: C07C235/76 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I [R represents -CH2CO2R or formulae II or III (R represents 1-4C alkyl)]. EXAMPLE:A monohydrate of a platinum-containing compound of N-(ethoxycarbonylmethyl)maleamidonato-hydroxo(trans-l-1,2-diaminocyclo hexane). USE:A remedy for malignant tumor. PREPARATION:A dinitrato(1,2-diaminocyclohexane)platinum (II) or disulfato(1,2- diaminocyclohexane)platinum (II) expressed by formula IV [R represents (ONO2)2 or OSO3] is reacted with a maleimide compound expressed by formula V in the presence of an alkali hydroxide.

公开(公告)号：JPH01163191A

公开(公告)日：1989-06-27

申请号：JP32230087

申请日：1987-12-18

Applicant: TORAY INDUSTRIES

Inventor： HASEGAWA SAKIE ,  IMAMURA SHINZO ,  MUTOU MASANORI ,  SAWAHATA TADASHI

IPC: A61K33/24 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I (R represents 1-17C alkyl). EXAMPLE:5-Acetyl-2,2-dimethyl-1,3-dioxan-4,6-dione-hydroxo(trans-l-1,2- diaminocyclohexane) platinum(II). USE:A remedy for malignant tumor, which is administrated at 0.01-50mg per day.adult body weight. PREPARATION:Dinitrato(1,2-diaminocyclohexane)platinum(II) expressed by formula II is reacted with a 5-acyl-2,2-dimethyl-1,3-dioxane-4,6-dione expressed by formula III in the presence of an alkali hydroxide normally at ordinary temperature under ordinary pressure.

公开(公告)号：JPH01104194A

公开(公告)日：1989-04-21

申请号：JP26202487

申请日：1987-10-16

Applicant: TORAY INDUSTRIES

Inventor： SATOU HARUYO ,  IMAMURA SHINZO

IPC: C12P41/00 ,  C12R1/22 ,  C12R1/645

Abstract: PURPOSE:To produce D-(-)-tartaric acid with industrially advantage by culturing a microorganism which is capable of assimilating L-(+)-tartaric acid, but substantially not assimilating D-(-)-tartaric acid in a medium containing DL-tartaric acid. CONSTITUTION:A microorganism in Cryptococcus, Trichosporon, or Klebsiella, capable of assimilating L-(+)-tartaric acid, but substantially not assimilating D-(-)-tartaric acid, is cultured in a medium containing DL-tartaric acid to effect asymmetric decomposition of L-(+)-tartaric acid. Then, remaining D-(-)- tartaric acid is isolated and collected from the culture mixture. An example of the microorganism is Cryptococcus laurentii ATCC 36832. The concentration of DL-tartaric acid in the medium is usually 1-300g/l, preferably 30-150g/l.

公开(公告)号：JPH0120150B2

公开(公告)日：1989-04-14

申请号：JP7724481

申请日：1981-05-21

Applicant: TORAY INDUSTRIES

Inventor： SATO HARUYO ,  IMAMURA SHINZO

IPC: C07D211/88