公开(公告)号：JPH0311090A

公开(公告)日：1991-01-18

申请号：JP14386689

申请日：1989-06-06

Applicant: TORAY INDUSTRIES

Inventor： MATSUNAGA KEIICHI ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07C49/733 ,  C07C211/65 ,  C07F15/00

Abstract: NEW MATERIAL:2-Acetylindane-1,3-dionyl-monohydroxo(trans-l- diaminocyclohexane)platinum of formula I. USE:A remedy for malignant tumor. PREPARATION:The objective compound can be produced by reacting dinitrato(1,2-diaminocyclohexano)platinum(II) or sulfato(1,2-diaminocyclohexane)platinum(II) of formula II [R is (NO3)2 or SO4] with 2-acetylindane-1,3-dione of formula III in the presence of an alkali metal or alkaline-earth metal hydroxide (preferably sodium hydroxide, potassium hydroxide or barium hydroxide) or reacting dihydroxo(1,2-diaminocyclohexane)platinum(II) of formula IV with the compound of formula III.

公开(公告)号：JPH049393A

公开(公告)日：1992-01-14

申请号：JP10992290

申请日：1990-04-25

Applicant: TORAY INDUSTRIES

Inventor： NAMITA TAKESHI ,  KANEKO TATSUYA ,  MUTOU MASANORI ,  OKAMOTO YUTAKA

IPC: C07F15/00

Abstract: NEW MATERIAL:A compound shown by formula I {R is group shown by formula II or formula III [R and R are 2-6C aliphatic hydrocarbon or R and R may be bonded to form -(CH2)n-(n is 3-5)]]. EXAMPLE:A compound shown by formula IV. USE:A remedy for tumors. PREPARATION:A compound shown by formula V is reacted with a compound shown by formula VI.

公开(公告)号：JPH02286694A

公开(公告)日：1990-11-26

申请号：JP10851189

申请日：1989-04-27

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07C211/65 ,  C07F15/00

Abstract: NEW MATERIAL:Bis-[3-(4-hydroxyphenyl)propionato]-(trans-l-1,2 diaminocyclohexane)platinum (II) complex shown by formula I. USE:A remedy against malignant tumor having low toxicity. PREPARATION:A dinitorato(1,2-diaminocyclohexane)platinum (II) shown by formula II [R is (NO3)2 or SO4] or sulfato(1,2-diaminocyclohexane)platinum (Il) is reacted with 3-(4-hydroxyphenyl)propionic acid shown by formula III in the presence of an alkaline (earth) metal hydroxide or dihydroxo (1,2- diaminocyclohexane)platinum (II) is reacted with a compound shown by formula III.

公开(公告)号：JPH01311089A

公开(公告)日：1989-12-15

申请号：JP14221688

申请日：1988-06-09

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASANORI ,  OKAMOTO YUTAKA

IPC: A61K33/24 ,  A61K31/28 ,  A61K31/282 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound of formula I. USE:An malignant tumor remedy. PREPARATION:A dinitrato (1,2-diaminocyclohexane)platinum (II) or sulfato (1,2-diaminocyclohexane)platinum (II) of formula II [R is (NO2)2 or OSO3] is reacted with a compound of formula III in the presence of an alkali hydroxide (preferably sodium hydroxide, potassium hydroxide or barium hydroxide) to provide the compound of formula I. The compound of formula II can be pre pared by reacting a compound of formula IV with K2PtCl4 and subsequently reacting the prepared compound of formula V with AgNO3.

公开(公告)号：JPH01128991A

公开(公告)日：1989-05-22

申请号：JP28496887

申请日：1987-11-11

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASAMITSU ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  OKAMOTO YUTAKA

IPC: C07F15/00 ,  A61K31/555 ,  A61P35/00

Abstract: NEW MATERIAL:The compound of formula I. USE:A remedy for malignant tumors. PREPARATION:Coumarinic acid of formula III is allowed to react with an aqueous solution of dihydroxodiaminocyclohexane Pt(II) to give the compound of formula I. The compound of formula II is obtained by allowing K2ptcl4 to react with a compound of formula IV to give a compound of formula V, then allowing the product to react with silver nitrate into the compound of formula VI, then passing the product through an OH-type anion-exchange resin.

公开(公告)号：JPH01272592A

公开(公告)日：1989-10-31

申请号：JP10193888

申请日：1988-04-25

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: C07C235/76 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I [R represents -CH2CO2R or formulae II or III (R represents 1-4C alkyl)]. EXAMPLE:A monohydrate of a platinum-containing compound of N-(ethoxycarbonylmethyl)maleamidonato-hydroxo(trans-l-1,2-diaminocyclo hexane). USE:A remedy for malignant tumor. PREPARATION:A dinitrato(1,2-diaminocyclohexane)platinum (II) or disulfato(1,2- diaminocyclohexane)platinum (II) expressed by formula IV [R represents (ONO2)2 or OSO3] is reacted with a maleimide compound expressed by formula V in the presence of an alkali hydroxide.

公开(公告)号：JPH01246245A

公开(公告)日：1989-10-02

申请号：JP7298288

申请日：1988-03-25

Applicant: TORAY INDUSTRIES

Inventor： HASEGAWA SAKIE ,  MATSUNAGA KEIICHI ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: C07C211/65 ,  A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07C45/00 ,  C07C49/403 ,  C07C67/00 ,  C07C209/00 ,  C07F15/00

Abstract: NEW MATERIAL:A platinum(II) complex shown by formula I (R is 1-17C alkyl). EXAMPLE:2-Acetyl-5,5-dimethylcyclohexane-1,3-dione-hydroxo(trans-l-1, 2- diaminocyclohexane)platinum(II) complex. USE:Useful as a remedy for malignant tumors. Showing strongly antitumor activity. When the complex is used, the complex is blended with a pharmaceutically acceptable excipient and administered in the form of tablet, pill, troche, injection, suppository, etc. The content of the compound shown by the formula in the remedy is 0.001-85wt.%, preferably 0. 005-60wt.%. PREPARATION:A platinum(Il) compound shown by formula II [ (R ) is (ONO2) or (OSO3)] is reacted with a compound shown by formula III and an alkali hydroxide to give a compound shown by formula I.

公开(公告)号：JPH0311091A

公开(公告)日：1991-01-18

申请号：JP14386789

申请日：1989-06-06

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: C07D307/33 ,  A61K31/555 ,  A61K33/24 ,  A61P35/00 ,  C07C211/65 ,  C07F15/00

Abstract: NEW MATERIAL:The compound containing spiculisporato-(trans-l-1,2- diaminocyclohexane)platinum expressed by formula I. USE:A remedy for malignant tumor. PREPARATION:The objective compound can be produced by reacting dinitrato(1,2-diaminocyclohexane)platinum(II) or sulfato(1,2-diaminocyclohexane)platinum(II) of formula II [R is (NO3)2 or SO4] with spiculisporic acid of formula III in the presence of an alkali metal or alkaline-earth metal hydroxide (preferably sodium hydroxide, potassium hydroxide or barium hydroxide) or reacting dihydroxo(1,2-diaminocyclohexane)platinum(II) of formula IV with the compound of formula III.

公开(公告)号：JPH02311489A

公开(公告)日：1990-12-27

申请号：JP13077889

申请日：1989-05-24

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07C211/65 ,  C07C233/84 ,  C07F15/00

Abstract: NEW MATERIAL:Bis-(N-acetyltranexamato)-(trans-1,2-diaminocyclohexane) platinum (II)-containing compound shown by formula I. USE:A treating agent for malignant tumor. PREPARATION:A dinitrato(1,2-diaminocyclohexane) platinum (II) or sulfato(1,2- diaminocyclohexane) platinum (II) shown by formula II [R is (NO3)2 or SO4] or a platinum (II) compound shown by formula III is reacted with a compound shown by formula IV in the presence of an alkaline (earth) metallic hydroxide.

公开(公告)号：JPH01163192A

公开(公告)日：1989-06-27

申请号：JP32230187

申请日：1987-12-18

Applicant: TORAY INDUSTRIES

Inventor： HASEGAWA SAKIE ,  IMAMURA SHINZO ,  MUTOU MASANORI ,  OKAMOTO YUTAKA

IPC: A61K33/24 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I (R represents 1-17C alkyl). EXAMPLE:5-Acetyl-2,4,6(1H,3H,5H)-pyrimidine-trione-hydroxo(trans-l-1,2- diaminocyclohexane)platinum(II) complex.monohydrate. USE:A remedy for malignant tumor, which is administrated at 0.01-50mg per day.adult body weight. PREPARATION:Dinitrato(1,2-diaminocyclohexane)platinum (II) expressd by formula II is reacted with a 5-acyl-2,4,6(1H,3H,5H)-pyrimidine-trione in the presence of an alkali hydroxide normally at ordinary temperature under ordinary pressure.