MULTIPLE-LABEL FLUORESCENCE IMAGING USING EXCITATION-EMISSION MATRICES
    41.
    发明申请
    MULTIPLE-LABEL FLUORESCENCE IMAGING USING EXCITATION-EMISSION MATRICES 审中-公开
    使用激发排放矩阵的多标签荧光成像

    公开(公告)号:WO2006014494A2

    公开(公告)日:2006-02-09

    申请号:PCT/US2005/023994

    申请日:2005-07-06

    Abstract: Methods and devices are disclosed which apply an excitation-emission matrix (EEM) to a heterogeneous, two-dimensional sample, allowing a considerably larger number of emitting, e.g. fluorescent, labels to be used simultaneously. This may be accomplished by employing a spectroscopic method of excitation-emission matrices which allows discrimination of species with similar emission spectra, and also allows positive identification of energy transfer between emitting species. The methods and devices may employ a novel excitation-light scanning technique which allows imaging of the emission from the heterogeneous sample both in two spatial dimensions (length and width) and in two spectral dimensions (excitation and emission wavelength). This light scanning technique maximizes the throughput of excitation light, increasing the sensitivity and hence the reading speed of the instrument.

    Abstract translation: 公开了将激发发射矩阵(EEM)施加到异质二维样品的方法和装置,允许相当大量的发射,例如, 荧光,标签同时使用。 这可以通过采用激发发射矩阵的光谱方法来实现,其允许区分具有相似发射光谱的物质,并且还允许阳性鉴定发射物质之间的能量转移。 所述方法和装置可以采用新的激发光扫描技术,其允许在两个空间维度(长度和宽度)和两个光谱尺寸(激发和发射波长)中成像异质样品的发射。 这种光扫描技术使激发光的吞吐量最大化,从而提高了仪器的灵敏度和读取速度。

    OPTICAL METROLOGY SYSTEM FOR SPECTRAL IMAGING OF A SAMPLE
    42.
    发明公开
    OPTICAL METROLOGY SYSTEM FOR SPECTRAL IMAGING OF A SAMPLE 审中-公开
    OPTISCHES METROLOGIESYSTEM ZUR SPEKTRALEN ABBILDUNG EINER PROBE

    公开(公告)号:EP3074755A1

    公开(公告)日:2016-10-05

    申请号:EP14800193.6

    申请日:2014-10-29

    Abstract: An optical metrology device is capable of detection of any combination of photoluminescence light, specular reflection of broadband light, and scattered light from a line across the width of a sample. The metrology device includes a first light source that produces a first illumination line on the sample. A scanning system may be used to scan an illumination spot across the sample to form the illumination line. A detector spectrally images the photoluminescence light emitted along the illumination line. Additionally, a broadband illumination source may be used to produce a second illumination line on the sample, where the detector spectrally images specular reflection of the broadband illumination along the second illumination line. The detector may also image scattered light from the first illumination line. The illumination lines may be scanned across the sample so that all positions on the sample may be measured.

    Abstract translation: 光学测量装置能够检测光致发光的任何组合,宽带光的镜面反射以及穿过样品宽度的线的散射光。 测量装置包括在样品上产生第一照明线的第一光源。 扫描系统可以用于扫描样品上的照明点以形成照明线。 检测器对沿着照明线发射的光致发光进行光谱成像。 此外,宽带照明源可以用于在样本上产生第二照明线,其中检测器对第二照明线的宽带照明进行光谱反射。 检测器还可以对来自第一照明线的散射光进行成像。 可以在样品上扫描照明线,使得可以测量样品上的所有位置。

    Optischer Sensor und Verfahren zur optischen Inspektion von Oberflächen
    45.
    发明公开
    Optischer Sensor und Verfahren zur optischen Inspektion von Oberflächen 审中-公开
    Optischer传感器和Verfahren zur optischen Inspektion vonOberflächen

    公开(公告)号:EP1850119A1

    公开(公告)日:2007-10-31

    申请号:EP07105607.1

    申请日:2007-04-04

    Abstract: Ein Optischer Sensor wird zur Erfassung von punktförmigen, linienförmigen oder flächigen Defekten eingesetzt, die an glatten Oberflächen wie Glas auftreten können. Der Sensor bestehend aus:
    a) einem telezentrischen Laserscanner (12) mit
    - einem Laser (1) zur annähernd senkrechten Beleuchtung einer glatten Oberfläche (5),
    - einem Scannspiegel (2),
    - einer telezentrischen Optik (4) zur Führung von Beleuchtungs- und Detektionsstrahlen,

    b) einer Erfassungseinheit (11) mit
    - einer Detektoroptik (8),
    - einer zentralen Blende (9), die konzentrisch in der Nähe der Detektoroptik von dieser aus in Richtung auf den telezentrischen Laserscanner (4) positioniert ist,
    - einem hochempfindlichen Photomultiplier (6) zur Erfassung von Streulicht, das von Defekten auf glatten Oberflächen (5) ausgeht,
    - einer dem Photomultiplier (6) vorgeschalteten Schlitzblende (7).


    Anwendung/Produkt: Prüfanlage zur optischen Inspektion von Oberflächen

    Abstract translation: 传感器具有远心激光扫描器(12),其包括用于平坦表面区域(5)近似垂直点亮的激光器(1),用于引导照明和检测光束的扫描反射器(2)和远中心光学器件(4)。 检测单元(11)具有检测器光学系统(8)和中心狭缝(9),该中心狭缝(9)通过远程中心激光扫描仪的方向上的检测器光学系统同心地定位。 检测单元还具有超敏感光电倍增器,用于收集从平面表面积上的缺陷和光电倍增器(6)上游狭缝光阑(7)延伸的散射光。 还包括用于在平面表面积处收集点状,线形或层状缺陷的方法的独立权利要求。

    CONFOCAL FLUORESCENCE SLIDE SCANNER WITH PARALLEL DETECTION
    47.
    发明申请
    CONFOCAL FLUORESCENCE SLIDE SCANNER WITH PARALLEL DETECTION 审中-公开
    共焦荧光扫描仪并行检测

    公开(公告)号:US20130015370A1

    公开(公告)日:2013-01-17

    申请号:US13550291

    申请日:2012-07-16

    Abstract: An instrument and method for scanning a large specimen supported on a specimen holder has a plurality of illumination sources with each illumination, source being focused on a different focus spot of the specimen simultaneously. There are a plurality of spectrally resolved detectors to receive light reflected or emitted from the different focus spots simultaneously with each spectrally resolved detector receiving light from one illumination source only.

    Abstract translation: 用于扫描支撑在样本保持器上的大样本的仪器和方法具有多个照明源,每个照明源同时聚焦在样本的不同聚焦点上。 存在多个光谱分辨检测器,用于接收来自不同焦点的反射或发射的光,同时每个光谱分辨检测器仅接收来自一个照明源的光。

    Multiple-label fluorescence imaging using excitation-emission matrices
    48.
    发明授权
    Multiple-label fluorescence imaging using excitation-emission matrices 失效
    使用激发发射矩阵的多标记荧光成像

    公开(公告)号:US07532326B2

    公开(公告)日:2009-05-12

    申请号:US11175955

    申请日:2005-07-06

    Abstract: Methods and devices are disclosed which apply an excitation-emission matrix (EEM) to a heterogeneous, two-dimensional sample, allowing a considerably larger number of emitting, e.g. fluorescent, labels to be used simultaneously. This may be accomplished by employing a spectroscopic method of excitation-emission matrices which allows discrimination of species with similar emission spectra, and also allows positive identification of energy transfer between emitting species. The methods and devices may employ a novel excitation-light scanning technique which allows imaging of the emission from the heterogeneous sample both in two spatial dimensions (length and width) and in two spectral dimensions (excitation and emission wavelength). This light scanning technique maximizes the throughput of excitation light, increasing the sensitivity and hence the reading speed of the instrument.

    Abstract translation: 公开了将激发发射矩阵(EEM)施加到异质二维样品的方法和装置,允许相当大量的发射,例如, 荧光,标签同时使用。 这可以通过采用激发发射矩阵的光谱方法来实现,其允许区分具有相似发射光谱的物质,并且还允许阳性鉴定发射物质之间的能量转移。 所述方法和装置可以采用新的激发光扫描技术,其允许在两个空间维度(长度和宽度)和两个光谱尺寸(激发和发射波长)中成像来自异质样品的发射。 这种光扫描技术使激发光的吞吐量最大化,从而提高了仪器的灵敏度和读取速度。

    Optical spot grid array scanning system
    49.
    发明授权
    Optical spot grid array scanning system 有权
    光斑阵列扫描系统

    公开(公告)号:US07468507B2

    公开(公告)日:2008-12-23

    申请号:US11339044

    申请日:2006-01-25

    Abstract: A method for scanning a surface, consisting of focusing an array of optical beams using optics having an axis, so as to illuminate a region of the surface intercepted by the axis, such that each optical beam illuminates a portion of a respective sub-region within the region. The method further includes moving at least one of the array and the surface so as to cause a translation of the surface relative to the axis in a first direction. During the translation in the first direction, each of the optical beams is scanned over the respective sub-region in a second direction, which is different from the first direction.

    Abstract translation: 一种用于扫描表面的方法,其包括使用具有轴的光学器件聚焦光束阵列,以便照亮由所述轴线截取的表面的区域,使得每个光束照亮所述光束中的相应子区域的一部分 该区域。 所述方法还包括移动所述阵列和所述表面中的至少一个,以使所述表面相对于所述轴线在第一方向上平移。 在第一方向的平移期间,每个光束在与第一方向不同的第二方向上在相应的子区域上被扫描。

    System and method for multimode imaging
    50.
    发明申请
    System and method for multimode imaging 失效
    多模成像系统和方法

    公开(公告)号:US20070206192A1

    公开(公告)日:2007-09-06

    申请号:US11363938

    申请日:2006-03-01

    Abstract: A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved elative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.

    Abstract translation: 公开了一种用于至少一个样品的多模成像的系统和方法。 该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。 使用选自步骤样品移动和连续样品移动的样品移动技术将至少一个样品移动到光学系统。 该方法包括以下步骤:(1)选择成像系统的操作模式; (2)从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; (3)使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和(4)用检测器选择性地读取像素。

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