公开(公告)号：MX2017002333A

公开(公告)日：2017-08-28

申请号：MX2017002333

申请日：2015-08-21

Applicant: ACADEMIA SINICA

Inventor： HSIN-YU LEE ,  CHUNG-YI WU ,  CHI-HUEY WONG

IPC: C07K14/33 ,  C07K14/34

Abstract: Esta divulgación incluye una composición inmunogenica que contiene (a) a un conjunto de glicano que incluye un portador y uno o más glicanos, en donde cada uno de los uno o más glicanos se conjugan con el portador mediante un enlazador, y opcionalmente (b) un adyuvante. Los uno o más glicanos son cada uno un derivado de Globo H.

公开(公告)号：ES2623545T3

公开(公告)日：2017-07-11

申请号：ES12172956

申请日：2009-05-01

Applicant: ACADEMIA SINICA

Inventor： YU SU-MAY ,  KO SWEE-SUAK ,  HSING YUE-IE C ,  HO TUAN-HUA DAVID ,  LO SHUEN-FANG

IPC: C12N15/82 ,  A01H5/00

Abstract: Un procedimiento para aumentar el tamaño el tamaño de la semilla en una planta al transformar una planta anfitriona o células de la planta anfitriona con un montaje de ADN recombinado que contiene una secuencia activadora operativamente unida a un polinucleótido que codifica un polipéptido que tiene una secuencia de aminoácidos al menos 80% idéntica a la secuencia SEQ. ID. nº: 103, siendo funcional la secuencia activadora en una célula de la planta anfitriona o en las células de la planta anfitriona.

公开(公告)号：AU2016207112A1

公开(公告)日：2017-06-15

申请号：AU2016207112

申请日：2016-01-18

Applicant: ACADEMIA SINICA

Inventor： CHANG TSE-WEN ,  CHU HSING-MAO ,  CHEN JOU-HAN ,  LIN CHUN-YU ,  LIN CHIEN-JEN

IPC: C07K16/46 ,  A61K39/395 ,  C12P21/08

Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

公开(公告)号：AU2015339463A1

公开(公告)日：2017-06-08

申请号：AU2015339463

申请日：2015-10-27

Applicant: ACADEMIA SINICA ,  LIANG CHI-MING ,  CHEN YET-RAN ,  CHEN YING-LAN ,  TSENG MEI-CHUN

Inventor： CHEN YET-RAN ,  CHEN YING-LAN ,  TSENG MEI-CHUN

IPC: A61K38/00 ,  C12N5/00

Abstract: The present invention relates to a novel plant defense signaling peptide and applications thereof.

公开(公告)号：BR112014011601A2

公开(公告)日：2017-05-30

申请号：BR112014011601

申请日：2012-10-27

Applicant: ACADEMIA SINICA

Inventor： LEE-TIAN CHANG ,  WEN-CHIN YANG

IPC: A61K36/00 ,  A01N25/08 ,  A23K20/195

Abstract: resumo “bidens pilosa e compostos poliacetilênicos para a prevenção e para o tratamento de coccidiose” é divulgada uma composição para uso na prevenção, na inibição e/ou no tratamento de coccidiose em um animal. a composição compreende uma quantidade eficiente de bidens pilosa, um constituinte ativo da mesma ou um composto ativo isolado da mesma. em outro aspecto, é divulgada uma composição para uso na prevenção e/ou no tratamento de coccidiose e/ou no aprimoramento do crescimento em um animal, a composição compreendendo um alimento para animais e uma quantidade eficiente de bidens pilosa ou um constituinte ativo isolado que compreende um composto poliacetilênico.

公开(公告)号：IL250957D0

公开(公告)日：2017-04-30

申请号：IL25095717

申请日：2017-03-06

Applicant: ACADEMIA SINICA

IPC: C07H20060101

Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.

公开(公告)号：CA2723095C

公开(公告)日：2016-12-13

申请号：CA2723095

申请日：2009-05-01

Applicant: ACADEMIA SINICA

Inventor： YU SU-MAY ,  KO SWEE-SUAK ,  HSING YUE-IE C ,  HO TUAN-HUA DAVID ,  LO SHUEN-FANG

IPC: C12N15/29 ,  A01H1/00 ,  A01H5/00 ,  C07K14/415 ,  C12N15/82

Abstract: A method of making a transgenic plant by transforming into a host plant a recombinant DNA construct that expresses in the transgenic plant a rice polypeptide and the transgenic plant thus produced.

公开(公告)号：IL215430A

公开(公告)日：2016-11-30

申请号：IL21543011

申请日：2011-09-27

Applicant: ACADEMIA SINICA ,  CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

Inventor： CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

IPC: A61K20060101

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：AU2013370009B2

公开(公告)日：2016-11-17

申请号：AU2013370009

申请日：2013-12-31

Applicant: ACADEMIA SINICA ,  DCB USA LLC ,  DEV CT BIOTECHNOLOGY

Inventor： LAI JIANN-SHIUN ,  WANG HUNG-LING ,  HUANG CHAO-YANG ,  LOK YING-YUNG ,  CHEN YUAN-TSONG ,  CHAN WOAN-ENG ,  HU CHIH-YOUNG

IPC: C07K16/18 ,  A61K39/395

Abstract: An anti-granulysin antibody, or an scFv or Fab fragment thereof, capable of binding to an epitope region from R64 to R113 of granulysin and capable of neutralizing an activity of granulysin. The antibody may contain a sequence selected from the sequences of SEQ ID NO:82 to SEQ ID NO: 195, or the antibody may contain a sequence selected from the sequences of SEQ ID NO:39 to SEQ ID NO:76. The antibody may be a monoclonal antibody. A method for treating or preventing an unwanted immune response disorder includes administering to a subject in need thereof an effective amount of an anti-granulysin antibody capable of neutralizing the activity of granulysin. The unwanted immune response disorder may be SJS, TEN, or GVHD.

公开(公告)号：SG11201607046VA

公开(公告)日：2016-10-28

申请号：SG11201607046V

申请日：2015-06-16

Applicant: ACADEMIA SINICA

Inventor： CHEN JIUN-BO ,  SHIUNG YU-YU ,  CHANG TSE-WEN

IPC: C07K16/00 ,  A61K39/00 ,  C12P21/08

Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.