公开(公告)号：EP0299661A3

公开(公告)日：1990-08-29

申请号：EP88306089.9

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Geiselman, Theodore S. ,  Rasmussen, James

IPC: G01N35/08

CPC classification number: G01N35/085

Abstract: A liquid handling system includes flow network module structure that defines a contained array of flow channels and a plurality of valves for controlling liquid flow through the flow channel array. The flow network module structure is adapted to be connected to an external source for applying a pressure differential to the flow network array to produce liquid flow within passages of the array. Also incorporated in the flow network module is chamber structure that is connected to the flow channel array and that has port structure in an outer surface of the module structure. Valve structure on the module structure is movable between a first position in which the port structure is closed and a second position in which the port structure is opened, the valve structure including actuator structure for moving a valve member between the first and second positions. Liquid transfer structure, including transport structure and probe structure carried on the transport structure, is adapted to cause movement of the valve structure from its first position to its second position concurrently with the movement of the probe structure into alignment with the chamber port structure for delivery of a quantity of sample material to the sample chamber and subsequent flow through the flow network array for interaction with an auxiliary fluid and transfer to an associated utilization device under the influence of an external pressure source.

公开(公告)号：EP0299659A3

公开(公告)日：1990-08-22

申请号：EP88306086.5

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Geiselman, Theodore S.

IPC: G01N35/08 ,  G01N35/06 ,  G01N1/00

CPC classification number: G01N35/085 ,  G01N35/10 ,  G01N2035/00326

Abstract: An analysis system includes analysis station structure, sample station structure spaced from the analysis station structure along a straight line path, support shaft structure disposed along an axis parallel to the straight line path, and a transport carriage with probe structure mounted on the carriage. The transport carriage is mounted on the support shaft structure for movement along that shaft and is keyed thereto for pivoting movement in response to rotation of the shaft. A first drive includes a drive motor and cable structure coupled between the carriage and the drive motor for moving the transport carriage along the shaft to selectively position the probe structure at the sample and analysis stations, and a second drive rotates the shaft for inserting the probe into and withdrawing the probe from chamber structure at the sample and analysis stations. Metering means coupled to the probe flows liquid into and discharges liquid from the probe.

公开(公告)号：EP0354604A3

公开(公告)日：1990-08-01

申请号：EP89201744.3

申请日：1989-06-29

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Premoli, Pietro

IPC: G01N27/416

CPC classification number: G01N27/4162

Abstract: A system is disclosed for measuring the partial pressure of a gas, and in particular of carbon dioxide (p CO ). The system uses an electrolytic solution of weak ionic strenght which is circulated between an ion-selective electrode and a membrane permeable to gases but not to the ions and substantially distant from the electrode. The partial pressure of the gas is measured after a fraction of the electrolytic solution has been permeated by the gas present in the sample and subsequently has been transferred on the sensible portion of the electrode.

公开(公告)号：EP0299658A3

公开(公告)日：1990-05-16

申请号：EP88306085.7

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Qureshi, Humayun ,  Liffman, Stanley M. ,  Webster, Milo E. ,  Geiselman, Theodore S.

IPC: G01N35/08

CPC classification number: G01N35/085 ,  G01N1/14 ,  G01N35/1097 ,  G01N2001/382 ,  G01N2035/00237 ,  Y10T436/117497

Abstract: An analysis system includes sample insertion module structure with structure defining a reduced pressure reservoir, structure defining a sample region, and structure defining a reagent circuit that includes metering chamber structure in series with the reagent circuit. First transfer valve structure is arranged to couple the sample region to the reagent circuit on one side of the metering chamber structure, and second transfer valve structure is arranged to couple the reagent circuit to the reduced pressure reservoir structure on the side of the metering chamber structure remote from the first transfer valve structure for inserting an intact metered quantity of sample liquid into a reagent stream.

公开(公告)号：EP0321032A1

公开(公告)日：1989-06-21

申请号：EP88202827.7

申请日：1988-12-09

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Zaccai, Gianfranco

IPC: A61B5/14

CPC classification number: A61B5/154 ,  A61B5/15003 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150732

Abstract: In a single-use device for collecting and holding blood samples, provision is made for an evacuated tube (10) with a closure (stopper) (11) that can be pierced by the tip of a needle (13), the other tip (14) of which is intended to be inserted into a vein of a patient. Disposed below the said pierceable stopper (11), and in the tube (10), is a diaphragm (16) intended to be passed through by the needle-tip (13) that pierces the stopper (11), so as to form a supplementar barrier between the interior of the tube (10) and the environment when the pierceable stopper (11) is removed.

Abstract translation: 在用于收集和保持血液样品的单次使用装置设置为，在真空管（10）具有一个封闭件（止动器）（11）也可通过针（13），另一个端头的尖端（刺穿制成 14的所有其目的）被插入到病人的静脉中。 设置在所述针刺止栓（11）的下方，并且在所述管（10）旨在是通过由针尖通过膜片（16）（13）做了刺穿塞子（11），以便形成一个 supplementar所述管（10）和所述环境当针刺止栓（11）被移除的内部之间的屏障。

公开(公告)号：EP0304151A2

公开(公告)日：1989-02-22

申请号：EP88306087.3

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Musacchio, John ,  Premoli, Pietro ,  Manzoni, Angelo ,  Bergkuist, Carolyn

IPC: G01N33/84

CPC classification number: G01N33/84

Abstract: A method for determining the concentrations of total calcium and at least one monovalent ion in a sample includes the steps of mixing the sample with a diluent that has a pH within the range pH 6.5 to 7.0 and includes 2-amino-2-hydroxymethyl-1,3 propanediol phosphate and is free of the monovalent ion. An aliquot of the diluted sample is concurrently contacted with a calcium-specific ion selective electrode and an ion selective electrode specifically responsive to the monovalent ion, the response of the calcium-specific ion selective electrode is measured as an indication of the concentration of total calcium in the sample, and the response of the monovalent ion specific ion selective electrode is measured as an indication of the concentration of the monovalent ion in the sample.

Abstract translation: 用于确定样品中总钙和至少一种一价离子浓度的方法包括以下步骤：将样品与pH在6.5至7.0范围内的pH值的稀释剂混合并包括2-氨基-2-羟甲基-1 ，3丙二醇磷酸酯，不含一价离子。 稀释的样品的等分试样同时与钙离子选择性电极和对单价离子特异性响应的离子选择性电极同时接触，测量钙离子选择性电极的响应作为总钙浓度的指示 在样品中，并且测量一价离子特异性离子选择电极的响应作为样品中一价离子浓度的指示。

公开(公告)号：EP0123178A2

公开(公告)日：1984-10-31

申请号：EP84103733.6

申请日：1984-04-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio

IPC: G01N21/07 ,  B04B5/04

CPC classification number: G01N21/07

Abstract: Analytical photometer for the practically simultaneous determination of the presence of different substances in a certain number of discrete samples. The photometer (10) is equipped with a centrifugal type rotor (16), already known in the art, containing a large number of chambers with inlet holes (20, 22) for the sample/samples and reagents and with axially aligned transparent windows, thereby forming a system of rotating cuvettes (18). The rotor compartments (16) serve as receptacles for the solutions and are designed and dimensioned as already known in the art, such as to retain the liquid when said rotor (16) is at rest and to transfer said liquid into the cuvettes (18) when the rotor (16) rotates. A single or multiple light source (L) is provided, which is transmitted in a novel manner through a system of suitable means, in particular, optical fibres (30-35) to various photodetector units (60 to 65), suitably aligned with the transparent windows of the cuvettes (18) by means of the same number of interference filters (50to 55) and appropriate holes (40 to 45) situated in the base (15) of the rotor (16). Thus it is possible to determine for the first time, concentrations of chemical solutions through the absorbance in the sample/samples plus reagent/reagents contained in the cuvettes (18) at various wave lengths, with wave energy being delivered from source (L).
Hence it is possible to examine more than one cuvette (18) almost simultaneously and singly, each one for a different analytical parameter, and consequently to examine the transmittance and/or absorbance of the samples contained in the cuvettes at optimum wave length.

Abstract translation: 分析光度计不同物质在离散样本的特定数目的存在的几乎同时测定。 光度计（10）配备有离心式转子（16），在本领域中已经公知的，含有用于样品/试样和试剂，并与轴向对准的透明窗口的大量具有入口孔腔（20，22）， 从而形成旋转的比色皿（18）的系统。 转子隔室（16）用作容器的解决方案，并且被设计和尺寸如在本领域中，颜色已经公知：如保留液体，当所述转子（16）是静止的，并与所述液体转移到比色皿（18） 当转子（16）旋转。 单个或多个光源（L）设置，其全部是以新颖的方式反mitted通过合适的装置的一个系统，特别是，光纤（30-35），以各个光电检测器单元（60至65），适当地与对齐的 试管（18）由相同数量的干涉滤光器（50至55）和适当的孔（40至45）位于所述转子（16）的基部（15）的手段的透明窗口。 因此，有可能为第一次确定的矿井，通过包含在在不同波长的比色皿（18）中，用波浪能抽样/样品加试剂/试剂的吸光度的化学溶液的浓度是从源（L）递送。 ... 因此，它可以检查一个以上的样本池（18）大致同时且单独地，每一个用于一个不同的分析参数，因此检查在最佳包含在比色杯中样品的透射率和/或吸光 波长。

公开(公告)号：EP2259071A2

公开(公告)日：2010-12-08

申请号：EP10180205.6

申请日：1999-04-20

Applicant: Instrumentation Laboratory S.p.A.

Inventor： Nebuloni, Luigi ,  Lattuada, Elena

IPC: G01N35/02 ,  G01N21/07 ,  G01N35/04

CPC classification number: G01N35/04 ,  G01N21/07 ,  G01N21/13 ,  G01N21/253 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/025 ,  G01N2035/0462 ,  Y10T436/111666

Abstract: The present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, in which the rotors are loaded automatically.
In particular, the present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, characterised in that it has a devices for loading the rotors (3) onto analysis apparatus (5) automatically, the device comprising a hopper (2) for supplying the rotors, the hopper (2) comprising asymmetric means for locating the rotors (3) positively in the hopper.

Abstract translation: 本发明涉及使用盘形转子的类型的光度分析装置，其中转子被自动加载。 特别地，本发明涉及使用盘形转子的类型的光度分析装置，其中它具有用于将转子（3）自动装载到分析装置（5）上的装置，该装置包括用于 供应转子，料斗（2）包括用于将转子（3）积极地定位在料斗中的不对称装置。

公开(公告)号：EP1046916A1

公开(公告)日：2000-10-25

申请号：EP99830228.5

申请日：1999-04-20

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Nebuloni, Luigi ,  Lattuada, Elena

IPC: G01N35/02 ,  G01N21/07

CPC classification number: G01N35/04 ,  G01N21/07 ,  G01N21/13 ,  G01N21/253 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/025 ,  G01N2035/0462 ,  Y10T436/111666

Abstract: The present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, in which the rotors are loaded automatically.
In particular, the present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, characterized in that it has a device for loading the rotors (3) onto analysis apparatus (5) automatically, the device comprising a hopper (2) for supplying the rotors, the hopper (2) comprising asymmetric means for locating the rotors (3) positively in the hopper.

Abstract translation: 转子精确地定位在料斗（2）中。 料斗供给用于自动加载到光度分析装置（1）上的转子（3）。 钳子（4）自动从转盘旁边的拾取位置传送转子。 对于用于光度分析装置的盘形转子，包括独立权利要求。

公开(公告)号：EP0872726A1

公开(公告)日：1998-10-21

申请号：EP97830175.2

申请日：1997-04-15

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Manzoni, Angelo ,  Daglio, Roberto ,  Frontini, Dario

IPC: G01N27/00 ,  G01N33/49 ,  G01N33/96 ,  G01N33/00

CPC classification number: G01N33/4925 ,  G01N33/0006 ,  G01N33/96 ,  G01N2496/70 ,  Y10T436/102499

Abstract: The present invention relates to a method for calibrating an instrument for the analysis of blood gases which possesses ion-sensitive electrodes and gas-sensitive electrodes and is used for the determination, in a biological fluid, of the concentration of electrolytes and metabolites in solution, and of the pH, pO 2 and pCO 2 , the said calibration being carried out with at least one buffered solution containing O 2 , a known or tonometer-measured amount of CO 2 and known concentrations of the electrolytes and metabolites to be determined, in which calibration the pO 2 titre is determined beforehand using atmospheric oxygen as reference.

Abstract translation: 本发明涉及一种用于校准的方法在溶液中具有仪器哪个离子敏感电极和气敏电极和用于测定血液气体的分析，在生物流体，电解质和代谢物的浓度， 和pH值，氧分压和二氧化碳分压的，所述的校准被执行与至少一个缓冲溶液包含O 2，公知的或CO 2的眼压计测量的量和已知的电解质和代谢物的浓度是确定的开采在哪个校准氧分压 滴度确定性开采预先使用大气中的氧作为参考。