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公开(公告)号:US11444605B2
公开(公告)日:2022-09-13
申请号:US17408599
申请日:2021-08-23
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor: Takeaki Yajima
Abstract: A spike generation circuit includes a first CMOS inverter connected between a first power supply and a second power supply, an output node of the first CMOS inverter being coupled to a first node that is an intermediate node coupled to an input terminal to which an input signal is input, a switch connected in series with the first CMOS inverter, between the first power supply and the second power supply, a first inverting circuit that outputs an inversion signal of a signal of the first node to a control terminal of the switch, and a delay circuit that delays the signal of the first node, outputs a delayed signal to an input node of the first CMOS inverter, and outputs an isolated output spike signal to an output terminal.
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公开(公告)号:US20220282294A1
公开(公告)日:2022-09-08
申请号:US17631407
申请日:2020-07-31
Applicant: Japan Science and Technology Agency
Inventor: Hiroshi Abe , Naoko Abe , Kosuke Nakamoto , Hiroki Murase , Yasuaki Kimura
Abstract: A primer for amplifying a nucleic acid having a structure represented by the formula (1): where B represents a base, R1 represents a decomposable protecting group, and R2 represents hydrogen or a hydroxyl group, and the symbol * represents a bond to a sugar of an adjacent nucleotide. A device for producing double-stranded DNA, includes: a forward primer and a reverse primer, having a structure represented by formula (1); a PCR device for forming double-stranded DNA with 3′-recessed ends by performing multiple cycles of PCR by using a template DNA as a template; and a photoirradiation unit for deprotecting R1 and forming a sticky end with a 3′-protruding end.
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公开(公告)号:US20220269968A1
公开(公告)日:2022-08-25
申请号:US17629718
申请日:2020-02-28
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor: Atsushi NOGUCHI , Yasunobu NAKAMURA
Abstract: A quantum gate device includes a first superconducting circuit which resonates at a first resonance frequency, second superconducting circuit which resonates at a second resonance frequency, and connector which connects these circuits. The first superconducting circuit includes a single first Josephson device, second Josephson device group, and first capacitor. The second Josephson device group includes n Josephson devices connected by a line made of a superconductor. The Josephson energy possessed by each of the n Josephson devices is greater than n times that of the first Josephson device. The quantum gate device further includes a magnetic field applier which applies a static magnetic field to the partial superconducting circuit, and an electromagnetic wave irradiator (first electromagnetic wave irradiator) which irradiates the first superconducting circuit and/or second superconducting circuit with an electromagnetic wave having a difference frequency which is equal to the difference between the first and second resonance frequencies.
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54.
公开(公告)号:US20220241754A1
公开(公告)日:2022-08-04
申请号:US17597101
申请日:2020-07-01
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor: Masaaki KITANO , Hideo HOSONO , Toshiharu YOKOYAMA , Kayato OOYA , Kiya OGASAWARA , Ryu TAKASHIMA
Abstract: The invention provides a method of producing a metal oxyhydride, capable of synthesizing the metal oxyhydride under reaction conditions close to atmospheric pressure, and excellent in productivity and cost. The method of producing a metal oxyhydride of the present invention includes reacting an oxide with a metal hydride in a hydrogen atmosphere. A non-oxygen element constituting the oxide comprises only one kind of non-oxygen element. A pressure condition of the reaction is 0.1 to 0.9 MPa, and a temperature of the reaction is 500 to 1000° C.
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公开(公告)号:US11384107B2
公开(公告)日:2022-07-12
申请号:US17050655
申请日:2019-04-26
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor: Takumi Konno , Satoshi Yamashita , Yasuhiro Nakazawa , Nobuto Yoshinari
Abstract: Provided is an easy-to-process thermoelectric conversion device whose shape can be freely changed. The device is provided containing electrodes and an ionic solid, wherein the ionic solid has: an anionic heterometal complex aggregated to form a crystal lattice; and a cationic species present in interstices of the crystal lattice, and wherein the anionic heterometal complex includes: a metal M1 selected from the group consisting of the elements of Groups 8, 9 and 10 of the Periodic Table and Cr and Mn; a metal M2 selected from the group consisting of the elements of Groups 11 and 12 of the Periodic Table; and a ligand.
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公开(公告)号:US20220204569A1
公开(公告)日:2022-06-30
申请号:US17601174
申请日:2020-04-09
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor: Yasushi OKADA , Daisuke INO , Kazuho IKEDA
IPC: C07K14/195 , C12N15/62 , C12N15/85 , C12N15/88 , C12Q1/6876 , C07K19/00 , A01K67/027 , A01K67/033 , G01N21/64
Abstract: The present invention provides a novel modified protein which is to be used, as a novel detection tool relating to gene expression, for detecting a chromatin open structure more easily at a higher sensitivity than by the conventional technique. The present invention relates to: a nucleic acid binding fluorescent protein, said protein containing a DNA binding domain in which 3 or more TAL-repeats are repeatedly connected, characterized by binding independently from base sequences; and a method for fluorescent labeling of an open chromatin in a vital cell, said method comprising a step for transferring a gene encoding a nucleic acid binding protein into the vital cell, characterized in that the nucleic acid binding protein is a protein comprising a DNA binding domain, in which 3 or more TAL-repeats are repeatedly connected, and a fluorescent protein directly or indirectly bound thereto and the DNA binding domain binds to a nucleic acid independently from base sequences.
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公开(公告)号:US11367824B2
公开(公告)日:2022-06-21
申请号:US16082476
申请日:2017-03-09
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor: Teppei Yamada , Hongyao Zhou , Nobuo Kimizuka
IPC: H01L35/28 , H01L35/24 , G01K7/02 , H01M14/00 , G01J5/12 , H01L35/04 , H01L35/14 , H01L35/34 , H01M6/36
Abstract: The present invention provides a thermoelectric conversion material having a considerably increased Seebeck coefficient, and a thermoelectric conversion device, a thermo-electrochemical cell and a thermoelectric sensor which include the material. The thermoelectric conversion material of the present invention includes a redox pair and a capture compound which captures only one of the redox pair selectively at low temperature and releases at high temperature.
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公开(公告)号:US20220177948A1
公开(公告)日:2022-06-09
申请号:US17299018
申请日:2019-12-03
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor: Yasushi OKADA , Tetsuro ARIYOSHI
IPC: C12Q1/6806 , C12Q1/6825 , C12Q1/6876
Abstract: The present invention provides a fluorogenic RNA capable of visualizing mRNA in cells, particularly, living mammalian cells, and a target RNA fluorescent labeling method using the fluorogenic RNA. The present invention provides a fluorogenic nucleic acid molecule containing a base sequence having two or more fluorescent molecule-binding regions linked via a linker sequence, in which one or more fluorescent molecule-binding aptamer sequences are inserted into a scaffold sequence of each of the fluorescent molecule-binding regions.
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公开(公告)号:US11352652B2
公开(公告)日:2022-06-07
申请号:US16976222
申请日:2019-03-04
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor: Naoki Takaya , Shunsuke Masuo , Yukie Kawasaki , Hajime Minakawa
IPC: C12P13/00
Abstract: Provided is a novel method for producing 4-aminocinnamic acid from 4-nitrophenylalanine. This method comprises: converting 4-nitrophenylalanine into 4-nitrocinnamic acid; and converting 4-nitrocinnamic acid into 4-aminocinnamic acid.
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公开(公告)号:US11320639B2
公开(公告)日:2022-05-03
申请号:US15920824
申请日:2018-03-14
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor: Masanori Matsuzaki , Shin-Ichiro Terada
Abstract: Describes herein are a microscope optical module, a microscope, a control device for the microscope optical module, and multiphoton excitation microscope, which can switch the observation field of view at high speed and observe a large field of view. The microscope optical module includes an optical-axis-shifting optical system having an optical element, an optical-axis-shifting optical system support for positioning the optical-axis-shifting optical system with respect to the objective light flux of the microscope, and a rotator arranged on the optical-axis-shifting optical system support, the rotator rotatably supporting the optical-axis-shifting optical system with respect to the optical axis of the objective light flux, wherein the microscope optical module is added to an objective light flux side of a microscope.
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