公开(公告)号：GB0916816D0

公开(公告)日：2009-11-04

申请号：GB0916816

申请日：2009-09-25

Applicant: PEARSON STUART A

公开(公告)号：GB0916503D0

公开(公告)日：2009-10-28

申请号：GB0916503

申请日：2009-09-21

Applicant: ECKERSLEY STUART A

公开(公告)号：DE3588239T3

公开(公告)日：2007-03-08

申请号：DE3588239

申请日：1985-06-17

Applicant: KAUFFMAN STUART A

Inventor： BALLIVET MARC ,  KAUFFMAN STUART A

IPC: C12N15/11 ,  G01N33/50 ,  A61K38/02 ,  A61K39/00 ,  A61K39/29 ,  C07H21/02 ,  C07H21/04 ,  C07K2/00 ,  C07K14/02 ,  C07K14/485 ,  C12N1/21 ,  C12N9/38 ,  C12N15/00 ,  C12N15/09 ,  C12N15/10 ,  C12N15/64 ,  C12N15/66 ,  C12N15/68 ,  C12N15/70 ,  C12P21/00 ,  C12Q1/68 ,  C12R1/19 ,  G01N33/15 ,  G01N33/48 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577

Abstract: Microbiologicale prodn. of peptides or polypeptides (I) comprises first producing, simultaneously in the same medium, many genes (A) composed at least partly of stochastic, synthetic polynucleotides, and introducing these genes into host cells. The (A)-contg. strains are cultured so as to clone (A) and induce expression of proteins coded by (A). The modified strains are screened/selected to identify those which produce the required (I), according to a particular property. These strains are then isolated and cultured to produce (I). In modification, the (A)-contg. transformants are selected for presence of a particular stochastic DNA or RNA sequence, and such sequences recovered from cultures of the appropriate strains.

公开(公告)号：GB0511607D0

公开(公告)日：2005-07-13

申请号：GB0511607

申请日：2005-06-07

Applicant: KING STUART A

IPC: G06F17/22

公开(公告)号：DE69816043T2

公开(公告)日：2004-04-22

申请号：DE69816043

申请日：1998-03-06

Applicant: BUSSE STUART A

Inventor： BUSSE STUART A

IPC: B60R19/00 ,  B60B7/00 ,  B60B30/00 ,  B60R20060101 ,  B60R19/42 ,  B60R21/34

公开(公告)号：GB0228276D0

公开(公告)日：2003-01-08

申请号：GB0228276

申请日：2002-12-04

Applicant: UNIV HERIOT WATT ,  MCNEILL STUART A ,  UNIV EDINBURGH

IPC: A61B5/103

Abstract: The present invention provides an apparatus suitable for use in investigating multi-phase biological tissue histology, which apparatus comprises a trans-ductally deployable probe mounting a periodically displaceable body of at least one tactile sensing device, said periodically displaceable body having an excitation frequency bandwidth in the range of from 1 Hz to 500 KHz, a maximum stroke length of less than 1 mm and a displacement force in the range from 0.01 N to 1 N, said displaceable body being provided with a displacement device having a displacement controller fro controlling at least said excitation frequency, said displaceable body being coupled to a displacement monitoring device and a displacement force monitoring device, for monitoring the viscoelastic response of said biological tissue to periodic compression by said displacement force applied to said tissue by periodic displacement of said periodically displaceable body. The present invention also includes a method for producing a histological profile of a biological tissue adjacent a body duct, and a diagnostic method, using the apparatus of the invention.

公开(公告)号：DE3588239T2

公开(公告)日：2003-01-02

申请号：DE3588239

申请日：1985-06-17

Applicant: KAUFFMAN STUART A

Inventor： BALLIVET MARC ,  KAUFFMAN STUART A

IPC: G01N33/50 ,  A61K39/00 ,  A61K39/29 ,  C07H21/02 ,  C07H21/04 ,  C07K14/02 ,  C07K14/485 ,  C12N1/21 ,  C12N9/38 ,  C12N15/00 ,  C12N15/09 ,  C12N15/10 ,  C12N15/64 ,  C12N15/66 ,  C12N15/68 ,  C12N15/70 ,  C12P21/00 ,  C12Q1/68 ,  C12R1/19 ,  G01N33/15 ,  G01N33/48 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577 ,  C12N15/11 ,  C07K2/00 ,  A61K38/02

Abstract: Microbiologicale prodn. of peptides or polypeptides (I) comprises first producing, simultaneously in the same medium, many genes (A) composed at least partly of stochastic, synthetic polynucleotides, and introducing these genes into host cells. The (A)-contg. strains are cultured so as to clone (A) and induce expression of proteins coded by (A). The modified strains are screened/selected to identify those which produce the required (I), according to a particular property. These strains are then isolated and cultured to produce (I). In modification, the (A)-contg. transformants are selected for presence of a particular stochastic DNA or RNA sequence, and such sequences recovered from cultures of the appropriate strains.

公开(公告)号：AU6205200A

公开(公告)日：2001-01-22

申请号：AU6205200

申请日：2000-06-30

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: C07D401/04 ,  A61K31/00 ,  A61K31/424 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/00 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/06 ,  A61P39/02 ,  A61P43/00 ,  C07D401/14 ,  C07D413/04 ,  C07D471/04 ,  C07D513/04 ,  A61K31/40 ,  A61K31/44 ,  A61K31/415

Abstract: The invention relates to a method of reducing neuronal injury or apoptosis including administering to a patient in need thereof an effective amount of a p38 mitogen-activated protein kinase (MAPK) inhibitor. Methods of treating an HIV-mediated dementia, glaucoma, or other neurodegenerative disorders are also disclosed.

公开(公告)号：DE69033668D1

公开(公告)日：2001-01-04

申请号：DE69033668

申请日：1990-01-30

Applicant: RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  C07K1/22 ,  C07K7/06 ,  C07K7/08 ,  C12N5/00 ,  C12N15/00 ,  G01N33/536

Abstract: Discoveries are disclosed that show particular aspect or recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as product of antibodies. Means are described fro determining the level of expression of genes for the KGF protein, for example by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

公开(公告)号：BR9808829A

公开(公告)日：2000-07-04

申请号：BR9808829

申请日：1998-03-06

Applicant: STUART A BUSSE

Inventor： BUSSE STUART A

IPC: B60R19/00 ,  B60B7/00 ,  B60B30/00 ,  B60R20060101 ,  B60R19/42 ,  B60R21/34