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公开(公告)号：KR101252338B1
公开(公告)日：2013-04-08
申请号：KR1020090132555
申请日：2009-12-29
Applicant: (주)아모레퍼시픽
Inventor： 나용주
Abstract: 본 발명은 검버섯 발생 진단 키트 및 검버섯 발생 진단 방법에 관한 것으로서, 구체적으로는 검버섯 발생에 따라 발현 패턴이 변화되는 유전자를 확인하여 검버섯 발생을 진단하기 위하여, 상기 유전자 서열의 폴리뉴클레오티드와 혼성화하는 프로브로서 하나 이상의 폴리뉴클레오티드 또는 그의 상보적 폴리뉴클레오티드; 상기 유전자 서열의 폴리뉴클레오티드의 프라이머 쌍; 또는 상기 유전자에 의하여 코딩되는 폴리펩티드에 대한 모노클로날 항체를 하나 이상 포함하는 검버섯 발생 진단 키트 및 그를 이용하는 검버섯 발생 진단 방법에 관한 것이다. 본 발명에 따르면 검버섯 발생에 따라 피부세포에서 정상치 이상으로 발현이 증가되는 64종의 유전자 및 발현이 감소되는 118종의 유전자를 검버섯 발생 마커 유전자로 하여 피부에서의 검버섯 발생을 빠르게 진단할 수 있다.
검버섯, 피부, 키트, 유전자 발현-
公开(公告)号：KR1020130022471A
公开(公告)日：2013-03-07
申请号：KR1020110084701
申请日：2011-08-24
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A cosmetic composition for containing a green tea ingredient is provided to concentration-dependently increase collagen biosynthesis and to basically treat aged skin. CONSTITUTION: A cosmetic composition contains one or more kinds selected from a group consisting of green tea saponin and green tea polyphenol as active ingredients. The composition further contains a culture product of green tea stem cells. The green tea polyphenol is EGCG(epigallicatechin gallate) extracted from green tea leaves. [Reference numerals] (AA) Control group; (BB) Green tea stem cell; (CC) Green tea saponin; (DD) Green tea EGCG; (EE) Green tea stem cell + green tea saponin; (FF) Green tea stem cell + green tea EGCG; (GG) Green tea saponin + green tea EGCG; (HH) Green tea stem cell + green tea saponin + green tea EGCG; (II) Fillagrin; (JJ) Catalase
Abstract translation: 目的：提供含有绿茶成分的化妆品组合物，以浓缩依赖地增加胶原蛋白生物合成，并基本治疗老化皮肤。 构成：化妆品组合物含有选自绿茶皂素和绿茶多酚作为活性成分的一种或多种。 该组合物还含有绿茶干细胞的培养物。 绿茶多酚是绿茶叶提取的EGCG（没食子没食子酸）。 （附图标记）（AA）对照组; （BB）绿茶干细胞; （CC）绿茶皂素; （DD）绿茶EGCG; （EE）绿茶干细胞+绿茶皂素; （FF）绿茶干细胞+绿茶EGCG; （GG）绿茶皂素+绿茶EGCG; （HH）绿茶干细胞+绿茶皂苷+绿茶EGCG; （II）Fillagrin; （JJ）过氧化氢酶
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公开(公告)号：KR1020120095296A
公开(公告)日：2012-08-28
申请号：KR1020120009404
申请日：2012-01-31
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/22 , A61K8/965 , A61K8/9706 , A61Q19/02 , A61Q19/08
Abstract: PURPOSE: A cosmetic composition for enhancing skin tone and elasticity is provided to maximally increase regeneration and purification abilities of the skin cells. CONSTITUTION: A cosmetic composition includes oxygen dissolved water as an active ingredient. The vegetable extract containing seaweeds extract or sulforaphane are included as an active ingredient. 0.1-80 weight% of the oxygen dissolved water is included based on the total weight. 0.001-10 weight% of the seaweeds extract is included based on the total weight. 0.001-10 weight% of the vegetable extract is included based on the total weight of the composition. The oxygen dissolved water contains 20-200 ppm of dissolved oxygen. The oxygen dissolved water is manufactured by injecting oxygen into deep sea water, glacier, subsurface water, thermal waters or distilled water using an oxygenator for 1-10 times for 10-120 minutes at the pressure of 1-10kg/cm2. The macroalgae is algae, rhodophyta, and fucoxanthin or micro alga. The Macroalgae is horsetail kelp or Spirulina.
Abstract translation: 目的：提供用于增强皮肤色调和弹性的化妆品组合物，以最大限度地增加皮肤细胞的再生和净化能力。 构成：化妆品组合物包含氧溶解水作为活性成分。 含有海草提取物或萝卜硫素的植物提取物作为活性成分。 基于总重量包括0.1-80重量％的氧溶解水。 基于总重量包括0.001-10重量％的海藻提取物。 基于组合物的总重量，包含0.001-10重量％的植物提取物。 氧溶解水含有20-200ppm的溶解氧。 氧气溶解水通过在1-10kg / cm 2的压力下，使用氧合器将氧气注入深海水，冰川，地下水，热水或蒸馏水中1-10次，持续10-120分钟来制造。 大藻类是藻类，紫罗兰色和岩藻黄素或微藻。 大海藻是马尾海螺或螺旋藻。
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公开(公告)号：KR1020120058737A
公开(公告)日：2012-06-08
申请号：KR1020100120161
申请日：2010-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/9706 , A61Q19/08
Abstract: PURPOSE: A cosmetic composition containing red algae is provided to regenerate epidermis and dermis on the skin and to improve anti-wrinkling with high safety. CONSTITUTION: A cosmetic composition for anti-aging contains 0.0001-25 wt% of red algae extract as an active ingredient. The red algae include Gelidium amansii, Gracilaria, gigartina, laver, Acanthopeltis japonica, gracilaria, Ceramium kondoi graphite or Grateloupia Filicina. The cosmetic composition is manufactured in the form of an emulsion, suspension, microemulsion, microcapsule, microgranule, or vesicle dispersion agent of ion type(liposome) and non-ion type.
Abstract translation: 目的：提供含有红藻的化妆品组合物，以再生皮肤上的表皮和真皮，并以高安全性改善抗皱纹。 构成：抗衰老化妆品组合物含有0.0001〜25重量％的红藻提取物作为活性成分。 红藻包括Gel include ii，江ia，g ina，紫菜，j ica，gr ia，ium oi石或花岗丝or。 化妆品组合物以离子型（脂质体）和非离子型的乳液，悬浮液，微乳液，微胶囊，微粒或囊泡分散剂的形式制造。
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公开(公告)号：KR1020120048727A
公开(公告)日：2012-05-16
申请号：KR1020100107001
申请日：2010-10-29
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/025 , C12N5/0698 , G01N33/5044 , C40B30/00 , C40B30/02 , G01N33/15
Abstract: PURPOSE: A method for evaluating skin elasticity enhancement using corium mimic is provided to observe binding force between fibroblast and collagenous fiber. CONSTITUTION: A method or evaluating skin elasticity enhancement using corium mimic comprises: a step of preparing a saccharification collagen control group and a saccharification experimental group; a step of mixing fibroblasts to the control and experimental groups each to prepare gel; a step of constructing three-dimensional form using a culture insert; a step of putting gel of the control and experimental groups inside the culture insert and culturing to prepare corium mimic; a step of imaging the shape of the mimic in a three-dimension; and a step of evaluating elasticity change from the image result.
Abstract translation: 目的：提供使用corium模拟物评估皮肤弹性增强的方法，以观察成纤维细胞和胶原纤维之间的结合力。 构成：使用corium模拟物的方法或评估皮肤弹性增强包括：制备糖化胶原对照组和糖化实验组的步骤; 将成纤维细胞与对照组和实验组混合以制备凝胶的步骤; 使用培养基构建三维形状的步骤; 将对照组和实验组的凝胶放入培养物插入物和培养物中制备ium模拟物的步骤; 在三维中成像模拟物的形状的步骤; 以及从图像结果评估弹性变化的步骤。
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Patent Agency Ranking
公开(公告)号：KR1020120024509A
公开(公告)日：2012-03-14
申请号：KR1020110090161
申请日：2011-09-06
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/19 , A61K8/0245 , A61K8/72 , A61K2800/10 , A61K2800/22 , A61K2800/61 , A61K2800/81 , A61Q19/00
Abstract: PURPOSE: An oxygen-generating cosmetic composition containing micro hydrogel particles and optical catalyst is provided to supply oxygen to skin and to improve anti-aging. CONSTITUTION: An oxygen-generating cosmetic composition contains micro hydrogel particles and optical catalyst which is conjugated to the hydrogel particles. The size of the hydrogel particles is 0.1-100 um. The hydrogel particle contains acryl-based hydrophilic monomers or polymers. The hydrogel particles are polyethylene glycol diacrylate, polyethylene glycol methacrylate, poly(N-isopropylacrylamide), or polymethylmethacrylate(PMMA).
Abstract translation: 目的：提供含有微水凝胶颗粒和光学催化剂的产氧化妆品组合物，以向皮肤供氧并改善抗老化性能。 构成：发氧化妆品组合物含有与水凝胶颗粒结合的微水凝胶颗粒和光学催化剂。 水凝胶颗粒的大小为0.1-100μm。 水凝胶颗粒含有基于丙烯酸的亲水单体或聚合物。 水凝胶颗粒是聚乙二醇二丙烯酸酯，聚乙二醇甲基丙烯酸酯，聚（N-异丙基丙烯酰胺）或聚甲基丙烯酸甲酯（PMMA）。
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公开(公告)号：KR1020110048738A
公开(公告)日：2011-05-12
申请号：KR1020090105435
申请日：2009-11-03
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A method for generating a skin wrinkles index and a method for providing beauty information for a skin are provided to create the skin wrinkles index and supply beauty information by the skin wrinkles index. CONSTITUTION: Values related to skin wrinkles is measured from a skin(S1). The skin is divided into a plurality of groups by the values(S2). A weighted value about values is determined using the number of groups(S4). A wrinkles index is created using the values and the weighted values(S5). The value comprises the average height of the wrinkles, the maximum height of protrusion, and the maximum distance between the protrusion and the concave.
Abstract translation: 目的：提供一种生成皮肤皱纹指数的方法和用于提供皮肤美容信息的方法，以产生皮肤皱纹指数并通过皮肤皱纹指数提供美容信息。 构成：与皮肤有关的值是从皮肤测量的（S1）。 通过值（S2）将皮肤分成多个组。 使用组数确定关于值的加权值（S4）。 使用值和加权值创建皱纹指数（S5）。 该值包括皱纹的平均高度，突起的最大高度以及突起和凹部之间的最大距离。
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公开(公告)号：KR1020080096026A
公开(公告)日：2008-10-30
申请号：KR1020070040859
申请日：2007-04-26
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
CPC classification number: C12Q1/6834 , G01N33/563
Abstract: A kit for predicting chloasma is provided to predict rapidly and sensitively potentialities of forming chloasma from skin by 23 kinds of genes highly revealed and 5 kinds of genes lowly revealed near the chloasma region. A kit for predicting chloasma comprises one or more monoclonal antibodies having the amino acid sequence coded by a gene selected from a group consisting of PCOLCE2, GFPT2, CCL21, WIF1 and H19 as a variable region. If an amount of the antigen combined in the antibody is less than a normal value, it is diagnose as the skin in which the chloasma is easily formed.
Abstract translation: 提供了一种用于预测黄褐斑的试剂盒，用于预测23种高度显示的基因和5种在黄褐斑区域附近低度显露的基因，从而快速灵敏地形成皮肤形成黄褐斑的潜力。 用于预测黄褐斑的试剂盒包含一种或多种具有由选自由PCOLCE2，GFPT2，CCL21，WIF1和H19组成的组的基因编码的氨基酸序列作为可变区的单克隆抗体。 如果抗体中组合的抗原量少于正常值，则诊断为容易形成黄褐斑的皮肤。
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公开(公告)号：KR1020070074090A
公开(公告)日：2007-07-12
申请号：KR1020060001810
申请日：2006-01-06
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/02 , A61K8/4926 , A61K8/4946
Abstract: A composition comprising a benzimidazole amine derivative or an aminoquinoline derivative is provided to inhibit signaling of a cell in melanocyte with which a c-kit protein is involved so as to control the function of the melanocyte, thereby providing skin-whitening effect. The composition for inhibiting c-kit protein or skin-whitening comprises 0.0001-10 wt.% of a benzimidazole amine derivative such as 1-(4-methoxyphenyl)-N-(1-naphthalenylmethal)-1H-benzimidazole-5-amine represented by the formula(1) or an aminoquinoline derivative such as 2-amino-3-(3,4-dimethoxyphenyl)-quinoline represented by the formula(2).
Abstract translation: 提供包含苯并咪唑胺衍生物或氨基喹啉衍生物的组合物以抑制黑素细胞的细胞的信号传导，其中涉及c-kit蛋白质以控制黑素细胞的功能，从而提供皮肤美白效果。 用于抑制c-kit蛋白或皮肤美白的组合物包含0.0001-10重量％的苯并咪唑胺衍生物，例如1-（4-甲氧基苯基）-N-（1-萘基甲基）-1H-苯并咪唑-5-胺，其代表 通式（1）表示的氨基喹啉衍生物或由式（2）表示的2-氨基-3-（3,4-二甲氧基苯基） - 喹啉。
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公开(公告)号：KR102200016B1
公开(公告)日：2021-01-08
申请号：KR1020170136562
申请日：2017-10-20
Applicant: (주)아모레퍼시픽
IPC: A61K8/9789 , A61K36/82 , A23L33/105 , A61Q19/00
Abstract: 본명세서에는녹차추출물을유효성분으로포함하는조성물로서, 미세먼지에의해발현량이영향을받는피부세포내 유전자인 KRT 1, CLDN 1, CLDN 4, 및 OCLN로이루어진군에서선택되는하나이상의발현량을정상수준으로조절하는미세먼지에의한피부손상케어용조성물이개시된다. 본발명에의한조성물을이용함으로써, 미세먼지에의해변화되는유전자발현량을정상수준으로되돌려피부세포의손상을케어할수 있다.
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