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公开(公告)号：KR1020140062615A
公开(公告)日：2014-05-26
申请号：KR1020120128530
申请日：2012-11-14
Applicant: 재단법인대구경북과학기술원
CPC classification number: A61K9/5123 , A61K9/1682 , A61K47/20 , A61K47/22
Abstract: The present invention relates to molecularly imprinted metal nanoparticles for binding with a serum amyloid P component protein and, more specifically, to metal nanoparticles for binding specifically with a serum amyloid P component protein (SAP) having a structure in which an azide-terminated self-assembled molecular layer is formed on the metal nanoparticle and a molecularly imprinted layer is formed on the azide-terminated self-assembled molecular layer. The nanoparticles bound with SAP of the present invention has an effect of inhibiting SAP binding to amyloid fibrils and mitigates the onsel of Alzheimer′s disease. The particles manufactured in the present invention can be used for SAP detection and concentration measurement together with an ability for inhibiting SAP binding to the amyloid fibrils.
Abstract translation: 本发明涉及用于与血清淀粉样蛋白P成分蛋白结合的分子印迹金属纳米粒子，更具体地说，涉及与具有结构的血清淀粉样蛋白P成分蛋白（SAP）特异性结合的金属纳米粒子， 在金属纳米粒子上形成组装的分子层，在叠氮化物封端的自组装分子层上形成分子印迹层。 与本发明的SAP结合的纳米颗粒具有抑制SAP与淀粉样蛋白原纤维结合并减轻阿尔茨海默病症状的作用。 本发明中制造的颗粒可与SAP检测和浓度测量一起用于抑制SAP结合淀粉样蛋白原纤维的能力。
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公开(公告)号：KR101334420B1
公开(公告)日：2013-11-29
申请号：KR1020110120209
申请日：2011-11-17
Applicant: 재단법인대구경북과학기술원
IPC: C08F290/06 , C08G83/00 , A61K9/127 , A61K47/48
Abstract: 내부에 약물이 봉입함으로써 약물의 독성으로 인한 부작용을 최소화 하고, 약물의 용해도를 증가시켜 치료 효과를 극대화 하며, 다양한 생리 조건에서 균일한 구형 구조를 유지함으로써 체내 안정성을 유지할 수 있는, 약물 전달체를 제공한다.
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公开(公告)号：KR101328141B1
公开(公告)日：2013-11-13
申请号：KR1020110109855
申请日：2011-10-26
Applicant: 재단법인대구경북과학기술원
Abstract: 셀룰로오스 에스테르와 폴리알킬렌글리콜을 주재로 포함하되, 상기 주재의 전체 중량에 대해 상기 셀룰로오스 에스테르는 50 내지 90 중량%, 상기 폴리알킬렌글리콜은 10 내지 50 중량%를 함유하는 안경테용 셀룰로오스 에스테르계 복합소재가 제공된다.
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公开(公告)号：KR101164138B1
公开(公告)日：2012-07-11
申请号：KR1020090130454
申请日：2009-12-24
Applicant: 재단법인대구경북과학기술원
IPC: C07D487/22 , A61K31/409 , A61P35/00
Abstract: 하기 화학식 1로 표시되는 수용성 포르피린 유도체를 포함하는 광역학치료용 수용성 나노구조체가 제공된다.
상기 식 중,
R
1 및 R
2 는 각각 독립적으로 -H 또는 -CH
3 이고,
R
3 및 R
4 는 각각 독립적으로 -OH, -OCH
3 , -NH
2 , -NHCH
3 , -NH(CH
3 )
2 , -NHCOCH
3 , -N(COCH
3 )
2 , -COR
5 , 또는 -CH
2 COR
5 (여기서, R
5 =-OH, -OCH
3 , -NH
2 , -NHCH
3 , 또는 -NH(CH
3 )
2 )이고,
m 및 n은 각각 독립적으로 21 내지 226의 정수이다.-
Patent Agency Ranking56.发明公开
公开(公告)号：KR1020120049057A
公开(公告)日：2012-05-16
申请号：KR1020100110626
申请日：2010-11-08
Applicant: 재단법인대구경북과학기술원
CPC classification number: C01B33/12 , B82Y30/00 , B82Y40/00 , C01B33/18 , C01P2004/64
Abstract: PURPOSE: A metal hydroxide based flame retardant-silica nanostructure, a manufacturing method thereof, and a flame-resistant insulating material including thereof are provided to improve dispersibility within a polymer resin of the metal hydroxide based flame retardant. CONSTITUTION: A manufacturing method of a metal hydroxide based flame retardant-silica nanostructure comprises next steps: forming an emulsion solution; dispersing the metal hydroxide based flame retardant into basic silicate aqueous solution; and reacting silicate solution with the emulsion solution. The basic silicate includes more than one kind which is selected from lithium silicate, sodium silicate, potassium silicate, magnesium silicate and sodium silicate potassium. The metal hydroxide based flame retardant includes more than one kind which is selected from magnesium hydroxide, calcium hydroxide, and aluminium hydroxide. A content amount of the metal hydroxide based flame retardant is 4-40 parts by weight based on 100.0 parts by weight of the basic silicate solution. The metal hydroxide based flame retardant-mixing silica nanostructure includes 1-60 parts by weight of the metal-hydroxide group flame retardant based on 100.0 parts by weight of silica nanoparticle.
Abstract translation: 目的：提供一种金属氢氧化物系阻燃二氧化硅纳米结构体及其制造方法以及包含其的阻燃绝缘材料，以提高金属氢氧化物系阻燃剂的聚合物树脂的分散性。 构成：金属氢氧化物基阻燃二氧化硅纳米结构的制造方法包括下列步骤：形成乳液; 将金属氢氧化物基阻燃剂分散在碱性硅酸盐水溶液中; 并使硅酸盐溶液与乳液溶液反应。 碱性硅酸盐包括选自硅酸锂，硅酸钠，硅酸钾，硅酸镁和硅酸钠钾中的一种以上。 金属氢氧化物类阻燃剂包括选自氢氧化镁，氢氧化钙和氢氧化铝中的一种以上。 基于100.0重量份的碱性硅酸盐溶液，金属氢氧化物基阻燃剂的含量为4-40重量份。 基于金属氢氧化物的阻燃混合二氧化硅纳米结构包括基于100.0重量份二氧化硅纳米颗粒的1-60重量份的金属氢氧化物阻燃剂。
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公开(公告)号：KR1020120048724A
公开(公告)日：2012-05-16
申请号：KR1020100105854
申请日：2010-10-28
Applicant: 재단법인대구경북과학기술원
Abstract: PURPOSE: A hydrogel is provided to give stimulation reaction by including negative polymers and positive ions and to maintain gel persistence. CONSTITUTION: A hydrogel comprises a hydrophilic or amphipathic polymer including two or more of phosphate(PO4 ^2) groups and polyhydric cation corresponding with negative charged phosphate (PO4^2). The polyhydric cation is selected from low molecular weight compound or polycation including more than 2 cations selected from -NH3 and -N2(CH3)3, and positive charged metal ion having more than bivalent, and combinations thereof. The hydrogel additionally includes 0-20 parts by weight of additive selected from NaCl, CaCl2, NaCSN, PEG and a combination thereof based on 100.0 parts by weight of membranous polymers.
Abstract translation: 目的：提供水凝胶，通过包括负性聚合物和阳离子进行刺激反应并保持凝胶持久性。 构成：水凝胶包含亲水或两亲性聚合物，其包括磷酸盐（PO4）2基团和对应于负电荷磷酸盐（PO 4 -2）的多羟基阳离子）的两种或多种。 多羟基阳离子选自低分子化合物或聚阳离子，包括多于2个选自-NH 3和-N 2（CH 3）3的阳离子，以及具有多于二价的带正电荷的金属离子及其组合。 基于100.0重量份膜聚合物，水凝胶另外包含0-20重量份的选自NaCl，CaCl 2，NaCSN，PEG及其组合的添加剂。
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公开(公告)号：KR1020120048236A
公开(公告)日：2012-05-15
申请号：KR1020100109773
申请日：2010-11-05
Applicant: 재단법인대구경북과학기술원 , (재)한국안광학산업진흥원
CPC classification number: Y02P20/542 , C08B1/02 , C08B1/003 , C08B3/06 , C08B3/26
Abstract: PURPOSE: A manufacturing method of cellulose ester is provided to improve substitution efficiency of a substituent, by using ionic liquid/dimethyl sulfoxide co-solvent system, and to effectively controlling reactivity, by stabilizing viscosity of reaction system. CONSTITUTION: A manufacturing method of cellulose ester comprises: a step of preparing a first solution comprising cellulose dissolved into ionic liquid; a step of preparing a second solution comprising a cyclic ester based monomer dissolved into dimethyl sulfoxide; and a step of esterificating the cellulose through ring opening-graft polymerization of reactive solution which is formed by mixing the first solution and the second solution. The volume ratio of the ionic liquid to the dimethyl sulfoxide is 1:0.5 - 1:4.
Abstract translation: 目的：提供一种纤维素酯的制备方法，通过使用离子液体/二甲基亚砜共溶剂系统，通过稳定反应体系的粘度，有效控制反应性，提高取代基的取代效率。 构成：纤维素酯的制造方法包括：制备包含溶解在离子液体中的纤维素的第一溶液的步骤; 制备包含溶解在二甲基亚砜中的基于环酯的单体的第二溶液的步骤; 以及通过将第一溶液和第二溶液混合形成的反应性溶液的开环接枝聚合来使纤维素酯化的步骤。 离子液体与二甲基亚砜的体积比为1:0.5-1:4。
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公开(公告)号：KR1020110075223A
公开(公告)日：2011-07-06
申请号：KR1020090131608
申请日：2009-12-28
Applicant: 재단법인대구경북과학기술원
CPC classification number: C08B5/00 , C08F251/02
Abstract: PURPOSE: A method for manufacturing thermoplastic cellulose polyester is provided to prepare cellulose ester having various thermal characteristics satisfying heat resistance of end-products and environmental-friendliness. CONSTITUTION: A method for manufacturing thermoplastic cellulose polyester comprises the steps of: acetylating at least a part of a hydroxyl group of the cellulose in ionic liquid to form cellulose acetate; and consecutively performing the ring opening graft polymerization of cyclic ester to a residual hydroxyl group of the cellulose acetate without the separation of the cellulose acetate from the ionic liquid. The acetylation is performed so that the cellulose is 1.0 ~ 2.9 per glucose unit.
Abstract translation: 目的：提供一种制备热塑性纤维素聚酯的方法，以制备具有满足最终产品耐热性和环境友好性的各种热特性的纤维素酯。 构成：制造热塑性纤维素聚酯的方法包括以下步骤：在离子液体中乙酰化纤维素的至少一部分羟基以形成乙酸纤维素; 并且将环状酯的开环接枝聚合连续地进行到乙酸纤维素的残留羟基，而不会从离子液体中分离出乙酸纤维素。 进行乙酰化，使纤维素为每个葡萄糖单位1.0〜2.9。
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公开(公告)号：KR1020100051163A
公开(公告)日：2010-05-17
申请号：KR1020080110187
申请日：2008-11-07
Applicant: 재단법인대구경북과학기술원
Abstract: PURPOSE: A method for manufacturing a nanostructure for photodynamic therapy is provided to ensure dispersion stability and generation efficiency of singlet oxygen. CONSTITUTION: A nanostructure for photodynamic therapy contains titania(TiO_2) nanoparticles and photosensitizer adsorbed on the surface of titania nanoparticle. A polymer dispersing agent is adsorbed on the surface of titania nanoparticles. The polymer dispersing agent is selected from polymethacrylic acid sodium salt, glycol chitosan, polyvinyl alcohol, polyethyleneimine, and polyethylene glycol. The photosensitizer is a phthalocyanine derivative containing copper phthalocyanine, zinc phthalocyanine, and aluminum phthalocyanine, and a porphyrin derivative containing protoporphyrin IX, aminolevulinic acid, and hematoporphyrin. A method for manufacturing the nanostructure comprises: a step of preparing titania sol; a step of inputting polymer dispersing agent to the titania sol to adsorb on the titania surface; and a step of inputting the photosensitizer to titania sol.
Abstract translation: 目的：提供一种用于制造光动力学治疗纳米结构的方法，以确保单线态氧的分散稳定性和发生效率。 构成：用于光动力学治疗的纳米结构包含二氧化钛（TiO_2）纳米颗粒和吸附在二氧化钛纳米颗粒表面上的光敏剂。 聚合物分散剂被吸附在二氧化钛纳米颗粒的表面上。 聚合物分散剂选自聚甲基丙烯酸钠盐，乙二醇壳聚糖，聚乙烯醇，聚乙烯亚胺和聚乙二醇。 光敏剂是含有酞菁铜，酞菁锌和铝酞菁的酞菁衍生物和含有原卟啉IX，氨基乙酰丙酸和血卟啉的卟啉衍生物。 制造纳米结构体的方法包括：制备二氧化钛溶胶的步骤; 将聚合物分散剂输入到二氧化钛溶胶中以吸附在二氧化钛表面上的步骤; 以及将光敏剂输入二氧化钛溶胶的步骤。
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