公开(公告)号：CA1328608C

公开(公告)日：1994-04-19

申请号：CA579269

申请日：1988-10-04

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  PLATTNER JACOB J ,  CROWLEY STEVEN R

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K37/64 ,  A61K31/00 ,  A61K37/02

Abstract: GLAUCOMA TREATMENT A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent: W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：AU3780393A

公开(公告)日：1993-09-13

申请号：AU3780393

申请日：1993-02-26

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  HALLAS ROBERT

IPC: C07D471/04 ,  A61K31/435 ,  A61K31/535 ,  A61K31/54 ,  A61P35/00 ,  C07D455/03 ,  C07D471/06 ,  C07D498/04 ,  C07D498/06 ,  C07D498/16 ,  C07D513/04 ,  C07D513/06 ,  A61K37/02 ,  C07K15/12

公开(公告)号：AU611953B2

公开(公告)日：1991-06-27

申请号：AU2330888

申请日：1988-09-30

Applicant: ABBOTT LAB

Inventor： STEIN HERBERT H ,  PLATTNER JACOB J ,  CROWLEY STEVEN R

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K37/64

Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha,alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：CA2001318A1

公开(公告)日：1990-04-25

申请号：CA2001318

申请日：1989-10-24

Applicant: ABBOTT LAB

Inventor： NORBECK DANIEL W ,  ROSEN TERRY J ,  PARIZA RICHARD J ,  SOWIN THOMAS J ,  PLATTNER JACOB J ,  GARMAISE DAVID L ,  HANNICK STEVEN M

IPC: C07D251/18 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  C07C61/04 ,  C07C67/347 ,  C07C69/635 ,  C07C215/42 ,  C07C271/18 ,  C07C271/20 ,  C07C271/24 ,  C07C275/50 ,  C07C321/24 ,  C07D213/69 ,  C07D239/10 ,  C07D239/46 ,  C07D239/47 ,  C07D239/54 ,  C07D251/16 ,  C07D253/06 ,  C07D253/065 ,  C07D403/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/02 ,  C07D473/18 ,  C07D473/26 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07F7/18 ,  C07F9/38 ,  C07F9/6561

Abstract: CARBOCYCLIC NUCLEOSIDE ANALOGS A compound of the formula: wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, OH, -CH2OH, -CH2OR20 wherein R20 i8 C1 to C6 alkyl, -CH20C(O)R21 wherein R21 is C1 to C10 alkyl, -CH20C(O)CH(R22)(NHR23) wherein R22 is tha side chain of any of the naturally occuring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein R24 is the side chain of any of the naturally occuring amino acids, -CH2SH, -CH2C1, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -CO)2R1, -CH2OH2OH, -CH2CH2OR20 R20 is as defined above, -CH2CH20C(O)R21 wherein R21 is as defined above, -CH2CH20C(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above, -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to 10 alkyl and R3 is hydrogen, C1 to C10 alkyl, carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof. (11-1088P)

公开(公告)号：DK529289D0

公开(公告)日：1989-10-24

申请号：DK529289

申请日：1989-10-24

Applicant: ABBOTT LAB

Inventor： NORBECK DANIEL W ,  ROSEN TERRY J ,  PARIZA RICHARD J ,  SOWIN THOMAS J ,  PLATTNER JACOB J ,  GARMAISE DAVID L ,  HANNICK STEVEN M

IPC: C07D251/18 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  C07C61/04 ,  C07C67/347 ,  C07C69/635 ,  C07C215/42 ,  C07C271/18 ,  C07C271/20 ,  C07C271/24 ,  C07C275/50 ,  C07C321/24 ,  C07D213/69 ,  C07D239/10 ,  C07D239/46 ,  C07D239/47 ,  C07D239/54 ,  C07D251/16 ,  C07D253/06 ,  C07D253/065 ,  C07D403/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/02 ,  C07D473/18 ,  C07D473/26 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07F7/18 ,  C07F9/38 ,  C07F9/6561 ,  C07C87/34 ,  C07C91/14 ,  C07C125/063 ,  C07C147/06 ,  C07C149/40 ,  C07F9/65

Abstract: A compound of the formula: wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, -OH, -CH2OH, -CH2OR20 wherein R20 is C1 to C6 alkyl, -CH2OC(O)R21 wherein R21 is C1 to C10 alkyl, -CH2OC(O)CH(R22)(NHR23) wherein R22 is the side chain of any of the naturally occuring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein R24 is the side chain of any of the naturally occuring amino acids, -CH2SH, -CH2Cl, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -CO2R1, -CH2CH2OH, -CH2CH2OR20 wherein R20 is as defined above, -CH2CH2OC(O)R21 wherein R21 is as defined above -CH2CH2OC(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to C10 alkyl and R3 is hydrogen, C1 to C10 alkyl carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof.

公开(公告)号：HRP20060276B1

公开(公告)日：2014-04-25

申请号：HRP20060276

申请日：2006-08-11

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  MA ZHENKUN ,  PLATTNER JACOB J ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/00

Abstract: Antimikrobni spojevi formulekao i njihove farmaceutski prihvatljive soli, njihovi esteri ili njihovi pred-lijekovi; farmaceutski sastavi koji sadrže te spojeve; metode za liječenje bakterijskih infekcija davanjem tih spojeva; i postupci za pripravljanje tih spojeva.

公开(公告)号：HRP20060278B1

公开(公告)日：2014-04-11

申请号：HRP20060278

申请日：2006-08-11

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  MA ZHENKUN ,  PLATTNER JACOB J ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/00

Abstract: Antimikrobni spojevi formule kao i njihove farmaceutski prihvatljive soli, njihovi esteri ili njihovi pred-lijekovi; farmaceutski sastavi koji sadrže te spojeve; metode za liječenje bakterijskih infekcija davanjem tih spojeva; i postupci za pripravljanje tih spojeva.

公开(公告)号：HRP20060277B1

公开(公告)日：2014-04-11

申请号：HRP20060277

申请日：2006-08-11

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  MA ZHENKUN ,  PLATTNER JACOB J ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/00

Abstract: Antimikrobni spojevi formulekao i njihove farmaceutski prihvatljive soli, njihovi esteri ili njihovi pred-lijekovi; farmaceutski sastavi koji sadrže te spojeve; metode za liječenje bakterijskih infekcija davanjem tih spojeva; i postupci za pripravljanje tih spojeva.

公开(公告)号：HRP20060275B1

公开(公告)日：2014-04-11

申请号：HRP20060275

申请日：2006-08-11

Applicant: ABBOTT LAB

Inventor： YAT SUN OR ,  CHU DANIEL T ,  MA ZHENKUN ,  PLATTNER JACOB J ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/00

Abstract: Antimikrobni spojevi formulekao i njihove farmaceutski prihvatljive soli, njihovi esteri ili njihovi pred-lijekovi; farmaceutski sastavi koji sadrže te spojeve; metode za liječenje bakterijskih infekcija davanjem tih spojeva; i postupci za pripravljanje tih spojeva.

公开(公告)号：CZ303474B6

公开(公告)日：2012-10-03

申请号：CZ2008589

申请日：1997-09-02

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  MA ZHENKUN ,  CLARK RICHARD F ,  CHU DANIEL T ,  PLATTNER JACOB J

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04

Abstract: Rešení se týká antimikrobiálních sloucenin 6-O-substituovaných ketolidu majících vzorec IV, stejne jako jejich farmaceuticky prijatelných solí; farmaceutických prostredku obsahujících takové slouceniny; jejich použití pro prípravu lécivého prípravku pro kontrolu bakteriální infekce u savcu a zpusobu pro prípravu takových sloucenin.