公开(公告)号：DE3853459D1

公开(公告)日：1995-05-04

申请号：DE3853459

申请日：1988-10-04

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  CROWLEY STEVEN R ,  PLATTNER JACOB J

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K38/07

Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha,alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：AT120370T

公开(公告)日：1995-04-15

申请号：AT88116399

申请日：1988-10-04

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  CROWLEY STEVEN R ,  PLATTNER JACOB J

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K38/07

Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha,alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：CA1328608C

公开(公告)日：1994-04-19

申请号：CA579269

申请日：1988-10-04

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  PLATTNER JACOB J ,  CROWLEY STEVEN R

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K37/64 ,  A61K31/00 ,  A61K37/02

Abstract: GLAUCOMA TREATMENT A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent: W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：AU611953B2

公开(公告)日：1991-06-27

申请号：AU2330888

申请日：1988-09-30

Applicant: ABBOTT LAB

Inventor： STEIN HERBERT H ,  PLATTNER JACOB J ,  CROWLEY STEVEN R

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K37/64

Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha,alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：AU624010B2

公开(公告)日：1992-05-28

申请号：AU5913190

申请日：1990-07-17

Applicant: ABBOTT LAB

Inventor： ROSENBERG SAUL H ,  SPINA KENNETH P ,  CROWLEY STEVEN R

IPC: C07D209/14 ,  A61K31/16 ,  A61K31/395 ,  A61K31/397 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/496 ,  A61K38/55 ,  A61P9/12 ,  C07C235/04 ,  C07C237/04 ,  C07C237/22 ,  C07D205/04 ,  C07D207/14 ,  C07D209/18 ,  C07D213/38 ,  C07D213/40 ,  C07D213/42 ,  C07D231/12 ,  C07D233/61 ,  C07D263/26 ,  C07D277/20 ,  C07D277/28 ,  C07D277/30 ,  C07D277/42 ,  C07D295/12 ,  C07D295/14 ,  C07D295/18 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D513/04 ,  C07D521/00 ,  C07K1/02 ,  C07K1/113 ,  C07K5/06 ,  C07K14/81 ,  C07K5/02 ,  A61K31/195 ,  A61K37/64 ,  C07K7/14

公开(公告)号：NZ226479A

公开(公告)日：1991-04-26

申请号：NZ22647988

申请日：1988-10-06

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  PLATTNER JACOB J ,  CROWLEY STEVEN R

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K37/02 ,  A61K9/06

Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha,alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：AU3566089A

公开(公告)日：1989-11-29

申请号：AU3566089

申请日：1989-05-12

Applicant: ABBOTT LAB

Inventor： KEMPF DALE J ,  PLATTNER JACOB J ,  NORBECK DANIEL W ,  BOYD STEVEN A ,  BAKER WILLIAM R ,  ERICKSON JOHN W ,  CROWLEY STEVEN R ,  FUNG ANTHONY K L

IPC: A61K31/16 ,  A61K31/275 ,  A61K31/335 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/365 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/405 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/44 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/54 ,  A61K38/00 ,  A61K38/55 ,  A61P31/12 ,  A61P43/00 ,  C07C233/36 ,  C07C233/47 ,  C07C235/10 ,  C07C235/12 ,  C07C237/10 ,  C07C237/12 ,  C07C237/22 ,  C07C271/22 ,  C07C317/44 ,  C07C323/60 ,  C07D207/12 ,  C07D207/337 ,  C07D213/81 ,  C07D231/12 ,  C07D233/32 ,  C07D233/36 ,  C07D233/64 ,  C07D239/04 ,  C07D239/10 ,  C07D257/04 ,  C07D263/06 ,  C07D263/16 ,  C07D263/20 ,  C07D263/22 ,  C07D263/24 ,  C07D263/26 ,  C07D265/06 ,  C07D265/10 ,  C07D271/10 ,  C07D273/00 ,  C07D277/28 ,  C07D277/64 ,  C07D277/66 ,  C07D295/20 ,  C07D295/205 ,  C07D295/215 ,  C07D307/14 ,  C07D307/28 ,  C07D307/58 ,  C07D307/68 ,  C07D309/04 ,  C07D309/20 ,  C07D317/34 ,  C07D317/36 ,  C07D333/38 ,  C07D407/04 ,  C07D413/04 ,  C07D413/06 ,  C07K5/06 ,  C07K5/065 ,  C07K5/103 ,  C07K5/107 ,  C07K7/02 ,  A61K37/02 ,  C07K7/06 ,  C07K7/08 ,  C07K7/10

公开(公告)号：DK560688A

公开(公告)日：1989-04-07

申请号：DK560688

申请日：1988-10-06

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  PLATTNER JACOB J ,  CROWLEY STEVEN R

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K37/64 ,  A61K31/00

Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha,alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：DK560688D0

公开(公告)日：1988-10-06

申请号：DK560688

申请日：1988-10-06

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  PLATTNER JACOB J ,  CROWLEY STEVEN R

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K37/64 ,  A61K31/00

Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha,alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：DE3853459T2

公开(公告)日：1995-11-09

申请号：DE3853459

申请日：1988-10-04

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  CROWLEY STEVEN R ,  PLATTNER JACOB J

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K38/07

Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha,alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.