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    Novel pyrrolopyrimidine compounds as inhibitors of protein kinases
    51.
    发明专利
    Novel pyrrolopyrimidine compounds as inhibitors of protein kinases 未知

    公开(公告)号：NZ629807A

    公开(公告)日：2017-04-28

    申请号：NZ62980713

    申请日：2013-07-11

    Applicant: ACEA BIOSCIENCES INC

    Inventor： WANG XIAOBO ,  MAO LONG ,  ZHAO LI ,  XI BIAO ,  XU XIAO

    IPC: C07D487/04 ,  A61K31/407 ,  A61K31/519 ,  A61P35/00

    Abstract: Disclosed herein are pyrrolopyrimidine derivatives of formula VIII where the substituents are as defined herein, pharmaceutical compositions containing them, and the use of the compounds in the manufacture of medicaments for the treatment of proliferation disorders and other diseases related to the dysregulation of kinases (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAKl, JAK2, JAK3, TEC and TXK) and/or the respective pathways. Specific examples of the compounds of formula VIII include N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide and N-(3-(2-( 4-(1-(2-fluoroethyl)azetidin-3-ylamino)-2-methoxyphenylamino )-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)phenyl)acrylamide.

    compostos heterocíclicos e usos como agentes anticancerígenos
    52.
    发明专利
    compostos heterocíclicos e usos como agentes anticancerígenos 未知

    公开(公告)号：BR112012020552A2

    公开(公告)日：2016-07-19

    申请号：BR112012020552

    申请日：2011-02-18

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LIU JIA ,  ZHAO LI ,  MAO LONG ,  XU XIAO ,  WANG XIAOBO

    IPC: C07D471/04 ,  A61K31/4188 ,  A61K31/437 ,  A61P35/00 ,  C07D513/04

    Abstract: compostos heterocíclicos e usos como agentes anticancerígenos. novos compostos possuindo um sistema bicíclico fundido de anel heteroaromático substituído com um anel de tiazole são divulgados. os compostos inibem o crescimento de uma variedade de tipos de células cancerosas, e são assim úteis no tratamento do câncer. a eficácia destes compostos é demostrada com um sistema de controle do crescimento/migração celular, o quew mostra que eles são inibidores potentes do crescimento e/ou migração das células cancerosas. além disso, os compostos da invenção foram mostrados para parar o crescimento de tumores in vivo, para reduzir o tamanho de tumores in vivo. as composições que compreendem estes compostos, e métodos para utilizar estes compostos e composições para o tratamento de câncer, são divulgados.

    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL
    57.
    发明专利
    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL 未知

    公开(公告)号：CA2853093A1

    公开(公告)日：2013-04-25

    申请号：CA2853093

    申请日：2012-10-22

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LI NAN ,  WU JIAN ,  CHEN YE ,  WANG TIANXING ,  WANG XIAOBO

    IPC: G01N15/14 ,  G01N15/00

    Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.

    HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS
    58.
    发明专利
    HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS 未知

    公开(公告)号：CA2789249A1

    公开(公告)日：2011-08-25

    申请号：CA2789249

    申请日：2011-02-18

    Applicant: ACEA BIOSCIENCES INC

    Inventor： MAO LONG ,  WANG XIAOBO ,  XU XIAO ,  ZHAO LI ,  LIU JIA

    IPC: C07D471/04 ,  A61K31/4188 ,  A61K31/437 ,  A61P35/00 ,  C07D513/04

    Abstract: Novel compounds having a fused bicyclic hetero aromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.

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