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    OPTICAL ENGINE FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE
    2.
    发明申请
    OPTICAL ENGINE FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE 审中-公开
    流量计，光流量计系统的光学发动机及其使用方法

    公开(公告)号：WO2015077349A2

    公开(公告)日：2015-05-28

    申请号：PCT/US2014066429

    申请日：2014-11-19

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LI NAN ,  CHEN YE ,  CHUNG HYUNSUN ,  LI ZENGQIANG ,  WANG XIAOBO

    IPC: G01N15/14 ,  G01N21/64 ,  G01N33/569

    CPC classification number: G01N21/645 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/6486 ,  G01N33/56972 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1438 ,  G01N2015/1477 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/06113

    Abstract: An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same plane; collection optics for collecting fluorescence from the flow cell; filtration optics that filter the collected fluorescence from the flow cell into different detection channels according to wavelength ranges; and a detector for each detection channel that converts the filtered fluorescence to electrical signals, wherein electrical signals are processed so that the fluorescence from each laser at the different vertical positions is distinguished at the same detector.

    Abstract translation: 一种用于台式流式细胞仪的光学引擎，该光学引擎包括一组激光器; 用于每个激光器的不同组的光束整形光学器件，其中每个组件包括两个透镜，用于可调节地将光沿x轴水平地聚焦到相同的水平位置，并且沿着y轴沿着同一平面垂直地垂直于不同的垂直位置; 用于从流动池收集荧光的收集光学器件; 过滤光学器件，根据波长范围将从流通池收集的荧光过滤到不同的检测通道; 以及用于将滤波后的荧光转换为电信号的每个检测通道的检测器，其中对电信号进行处理，使得来自不同垂直位置处的每个激光的荧光在相同的检测器处被区分。

    HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS
    3.
    发明申请
    HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS 审中-公开
    杂环化合物和作为抗癌剂的用途

    公开(公告)号：WO2009023402A3

    公开(公告)日：2009-04-23

    申请号：PCT/US2008070348

    申请日：2008-07-17

    Applicant: ACEA BIOSCIENCES INC ,  AN HAOYUN ,  XI BIAO ,  ABASSI YAMA ,  WANG XIAOBO ,  XU XIAO

    Inventor： AN HAOYUN ,  XI BIAO ,  ABASSI YAMA ,  WANG XIAOBO ,  XU XIAO

    IPC: C07D275/02

    CPC classification number: C07D487/04 ,  C07D498/04 ,  C07D513/04

    Abstract: Novel compounds having a fused bicyclic hetero aromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.

    Abstract translation: 公开了具有用杂芳基五元环取代的稠合双环杂芳族环系的新型化合物。 这些化合物抑制多种类型癌细胞的生长，因此可用于治疗癌症。 用监测细胞生长/迁移的系统证明了这些化合物的功效，其显示它们是癌细胞生长和/或迁移的有效抑制剂。 另外，本发明的化合物显示出可以停止体内肿瘤的生长，并且减小体内肿瘤的大小。 公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗癌症的方法。

    IMPEDANCE BASED DEVICES AND METHODS FOR USE IN ASSAYS
    6.
    发明申请
    IMPEDANCE BASED DEVICES AND METHODS FOR USE IN ASSAYS 审中-公开
    基于阻抗的设备和用于测量的方法

    公开(公告)号：WO2004010103A2

    公开(公告)日：2004-01-29

    申请号：PCT/US0322557

    申请日：2003-07-18

    Applicant: ACEA BIOSCIENCES INC ,  WANG XIAOBO ,  XU XIAO

    Inventor： WANG XIAOBO ,  XU XIAO

    IPC: G01N27/02 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12N1/00 ,  C12N13/00 ,  C12Q1/00 ,  C12Q1/02 ,  G01N20060101 ,  G01N1/00 ,  G01N27/06 ,  G01N27/12 ,  G01N27/30 ,  G01N27/327 ,  G01N27/416 ,  G01N33/50 ,  G01N33/543 ,  G01N37/00 ,  G01N

    CPC classification number: G01N33/5005 ,  G01N15/12 ,  G01N33/54366 ,  G01N33/5438

    Abstract: A device for detecting cells and/or molecules on an electrode surface is disclosed. The device detects cells and/or molecules through measurement of impedance changes resulting from the cells and/or molecules. A disclosed embodiment of the device includes a substrate having two opposing ends along a longitudinal axis. A plurality of electrode arrays are positioned on the substrate. Each electrode array includes at least two electrodes, and each electrode is separated from at least one adjacent electrode in the electrode array by an expanse of non-conductive material. The electrode has a width at its widest point of more than about 1.5 and less than about 10 times the width of the expanse of non-conductive material. The device also includes electrically conductive traces extending substantially longitudinally to one of the two opposing ends of the substrate without intersecting another trace. Each trace is in electrical communication with at least one of the electrode arrays.

    Abstract translation: 公开了一种用于检测电极表面上的电池和/或分子的装置。 该装置通过测量由细胞和/或分子产生的阻抗变化来检测细胞和/或分子。 所述装置的公开实施例包括具有沿着纵向轴线的两个相对端部的基板。 多个电极阵列位于基板上。 每个电极阵列包括至少两个电极，并且每个电极由电极阵列中的至少一个相邻的电极通过一片非导电材料分开。 电极的最宽点处的宽度大于非导电材料的宽度的大约1.5倍且小于约10倍。 该器件还包括基本上纵向延伸到衬底的两个相对端之一的导电迹线，而不与另一迹线相交。 每个迹线与至少一个电极阵列电连通。

    PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
    7.
    发明申请
    PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS 审中-公开
    吡嗪衍生物作为激酶抑制剂

    公开(公告)号：WO2015006754A3

    公开(公告)日：2015-03-12

    申请号：PCT/US2014046442

    申请日：2014-07-11

    Applicant: ACEA BIOSCIENCES INC

    Inventor： XU XIAO ,  WANG XIAOBO ,  MAO LONG ,  ZHAO LI ,  XI BIAO

    IPC: C07D417/12 ,  A61K31/506 ,  A61P35/00 ,  C07D239/545 ,  C07D239/553 ,  C07D403/12 ,  C07D473/18 ,  C07D487/04 ,  C07D519/00

    CPC classification number: C07D239/545 ,  C07D239/553 ,  C07D403/12 ,  C07D417/12 ,  C07D473/18 ,  C07D487/04 ,  C07D519/00

    Abstract: The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

    Abstract translation: 本发明涉及药物化合物，组合物和方法，特别是因为它们与用于治疗和/或预防增殖病症，癌症，肿瘤，炎性疾病，自身免疫性疾病，银屑病，干性疾病的组合物和方法有关 眼睛或免疫相关疾病，在一些实施方案中，与激酶失调相关的疾病或病症，例如但不限于EGFR（包括HER），Alk，PDGFR，BLK，BMX / ETK，FLT3（D835Y），ITK ，TEC，TXK，BTK或JAK，以及各自的途径。

    Nuevos compuestos de pirrolopirimidina como inhibidores de proteína cinasas
    9.
    发明专利
    Nuevos compuestos de pirrolopirimidina como inhibidores de proteína cinasas 未知

    公开(公告)号：ES2618007T3

    公开(公告)日：2017-06-20

    申请号：ES13745491

    申请日：2013-07-11

    Applicant: ACEA BIOSCIENCES INC

    Inventor： XU XIAO ,  WANG XIAOBO ,  MAO LONG ,  ZHAO LI ,  XI BIAO

    IPC: C07D487/04 ,  A61K31/52 ,  A61P35/00

    Abstract: Un compuesto de Fórmula (VIII):**Fórmula** en la que X1 es O, NH, S, CH2 o CF2; R1 y R2 se seleccionan independientemente de hidrógeno, halo, alquilo C1-6 y haloalquilo C1-6; R3 se selecciona de halo, hidroxilo, alquilo C1-6, alcoxi C1-6, ciano y nitro; n es un número de cero a 4; R4 se selecciona de hidrógeno, alquilo C1-6, cicloalquilo C3-7 y -NR22R23; en donde el alquilo o cicloalquilo no está sustituido o está sustituido con hidroxilo o amino; y cada uno de R22 y R23 se selecciona independientemente de hidrógeno y alquilo C1-6 o R22 y R23 pueden estar ligados para formar un anillo de 3 a 10 miembros; R5 se selecciona de hidrógeno y alquilo C1-6; R6 se selecciona de hidrógeno, halo, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, hidroxilo, ciano y nitro; R7 se selecciona de hidrógeno, halo, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, hidroxilo, ciano y nitro; R8 se selecciona de hidrógeno, halo, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, hidroxilo, ciano y nitro; Q es CR9 o N;~ donde R9 se selecciona de hidrógeno, halo, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, hidroxilo, ciano y nitro; R11 se selecciona de hidrógeno y alquilo C1-6; R12 se selecciona de hidrógeno y alquilo C1-6; R13 se selecciona de hidrógeno, alquilo C1-6, acilo C1-6, SO2-alquilo(C1-6), cicloalquilo C3-7 y arilo C6-20, en donde cada alquilo o arilo no está sustituido o está sustituido con hidroxilo, alcoxi C1-6 o halo; y -NR18R19 es**Fórmula** en donde R10 se selecciona de hidrógeno y alquilo C1-6; R15 es metilo no sustituido o es alquilo C2-4 no sustituido o sustituido con hidroxi, metoxi o halo; y m es 1 o 2; o es (b) donde R19 y R9 tomados juntos forman un anillo heteroarílico de 5 o 6 miembros opcionalmente sustituido con alquilo C1-6 que no está sustituido o está sustituido con amino, hidroxilo o halo; y R18 es hidrógeno o alquilo C1-6 o está ausente para satisfacer la valencia del anillo heteroarílico; con la condición de que ni R6 ni R7 sea metoxi cuando -NR18R19 sea**Fórmula** o una sal farmacéuticamente aceptable del mismo.

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