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    OPTICAL ENGINE FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE
    1.
    发明申请
    OPTICAL ENGINE FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE 审中-公开
    流量计，光流量计系统的光学发动机及其使用方法

    公开(公告)号：WO2015077349A2

    公开(公告)日：2015-05-28

    申请号：PCT/US2014066429

    申请日：2014-11-19

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LI NAN ,  CHEN YE ,  CHUNG HYUNSUN ,  LI ZENGQIANG ,  WANG XIAOBO

    IPC: G01N15/14 ,  G01N21/64 ,  G01N33/569

    CPC classification number: G01N21/645 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/6486 ,  G01N33/56972 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1438 ,  G01N2015/1477 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/06113

    Abstract: An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same plane; collection optics for collecting fluorescence from the flow cell; filtration optics that filter the collected fluorescence from the flow cell into different detection channels according to wavelength ranges; and a detector for each detection channel that converts the filtered fluorescence to electrical signals, wherein electrical signals are processed so that the fluorescence from each laser at the different vertical positions is distinguished at the same detector.

    Abstract translation: 一种用于台式流式细胞仪的光学引擎，该光学引擎包括一组激光器; 用于每个激光器的不同组的光束整形光学器件，其中每个组件包括两个透镜，用于可调节地将光沿x轴水平地聚焦到相同的水平位置，并且沿着y轴沿着同一平面垂直地垂直于不同的垂直位置; 用于从流动池收集荧光的收集光学器件; 过滤光学器件，根据波长范围将从流通池收集的荧光过滤到不同的检测通道; 以及用于将滤波后的荧光转换为电信号的每个检测通道的检测器，其中对电信号进行处理，使得来自不同垂直位置处的每个激光的荧光在相同的检测器处被区分。

    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL
    4.
    发明专利
    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL 未知

    公开(公告)号：CA2853093C

    公开(公告)日：2020-01-14

    申请号：CA2853093

    申请日：2012-10-22

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LI NAN ,  WU JIAN ,  CHEN YE ,  WANG TIANXING ,  WANG XIAOBO

    IPC: G01N15/14 ,  G01N15/00

    Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.

    DEVICE FOR SPLITTING LIGHT INTO COMPONENTS HAVING DIFFERENT WAVELENGTH RANGES AND METHODS OF USE
    5.
    发明专利
    DEVICE FOR SPLITTING LIGHT INTO COMPONENTS HAVING DIFFERENT WAVELENGTH RANGES AND METHODS OF USE 未知

    公开(公告)号：CA2853083C

    公开(公告)日：2020-03-10

    申请号：CA2853083

    申请日：2012-10-19

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LI NAN ,  CHEN YE ,  WANG XIAOBO

    IPC: G02B27/10 ,  G02B5/04

    Abstract: A prism including a substrate faceted to provide a plurality of flat surfaces, wherein at least two of the plurality of surfaces, each including a filter coating, form at least two filter surfaces, wherein each filter surface selectively permits passage of a predetermined wavelength and reflects remaining wavelengths along an optical path towards another of the plurality of surfaces, optionally another filter surface, wherein an angle of incidence of each of the plurality of surfaces along the optical path is equal or nearly equal. An apparatus incorporating the prism and its use for splitting a light spectrum into a plurality of wavelengths or wavelength ranges.

    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL
    7.
    发明专利
    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL 未知

    公开(公告)号：CA2853093A1

    公开(公告)日：2013-04-25

    申请号：CA2853093

    申请日：2012-10-22

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LI NAN ,  WU JIAN ,  CHEN YE ,  WANG TIANXING ,  WANG XIAOBO

    IPC: G01N15/14 ,  G01N15/00

    Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.

    OPTICAL DETECTION SYSTEM FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE
    8.
    发明专利
    OPTICAL DETECTION SYSTEM FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE 未知

    公开(公告)号：CA3030966A1

    公开(公告)日：2018-01-18

    申请号：CA3030966

    申请日：2017-07-15

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LI NAN ,  KONG LINGBO ,  WU JIAN ,  CHENG TINGTING ,  QING YANGDE ,  WANG XIAOBO

    IPC: G01N15/14 ,  G01N21/64

    Abstract: An optical engine its use in a bench top flow cytometer, the optical engine having a set of lasers, each focused horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same excitation plane of a flow cell, a set of optics that separate fluorescence of a same wavelength range into different locations in a focal plane of collection optics according to the different lasers by which the fluorescent light is excited; and a detector that selectively detects light from the different locations thereby distinguishing between fluorescence emitted within the same wavelength range as excited by the different lasers.

    DEVICE FOR SPLITTING LIGHT INTO COMPONENTS HAVING DIFFERENT WAVELENGTH RANGES AND METHODS OF USE
    9.
    发明专利
    DEVICE FOR SPLITTING LIGHT INTO COMPONENTS HAVING DIFFERENT WAVELENGTH RANGES AND METHODS OF USE 未知

    公开(公告)号：CA2853083A1

    公开(公告)日：2013-05-10

    申请号：CA2853083

    申请日：2012-10-19

    Applicant: ACEA BIOSCIENCES INC

    Inventor： LI NAN ,  CHEN YE ,  WANG XIAOBO

    IPC: G02B27/10 ,  G02B5/04

    Abstract: A prism including a substrate faceted to provide a plurality of flat surfaces, wherein at least two of the plurality of surfaces, each including a filter coating, form at least two filter surfaces, wherein each filter surface selectively permits passage of a predetermined wavelength and reflects remaining wavelengths along an optical path towards another of the plurality of surfaces, optionally another filter surface, wherein an angle of incidence of each of the plurality of surfaces along the optical path is equal or nearly equal. An apparatus incorporating the prism and its use for splitting a light spectrum into a plurality of wavelengths or wavelength ranges.

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