公开(公告)号：DK382785A

公开(公告)日：1986-02-26

申请号：DK382785

申请日：1985-08-23

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  LITTMANN WOLFGANG ,  PAUST JOACHIM

IPC: C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/27 ,  C07C255/30 ,  C07D239/42 ,  C07C ,  C07D

Abstract: alpha -(o-Chlorophenyl)-aminomethylene- beta -formylaminopropionitrile, process for its preparation by reacting a metal salt of alpha -formyl- beta -formylaminopropionitrile with a salt of o-chloroaniline in an aqueous medium, and use of the product to prepare the compound of the formula by reaction with acetamidine. The pyrimidine thus obtained is an intermediate for the preparation of vitamin B1.

公开(公告)号：DK32884A

公开(公告)日：1984-07-27

申请号：DK32884

申请日：1984-01-25

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  SCHMIDT WOLFRAM ,  PAUST JOACHIM

IPC: C07D475/14 ,  C07D475/02 ,  C07D

公开(公告)号：DK32884D0

公开(公告)日：1984-01-25

申请号：DK32884

申请日：1984-01-25

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  SCHMIDT WOLFRAM ,  PAUST JOACHIM

IPC: C07D475/14 ,  C07D475/02 ,  C07D475

公开(公告)号：PT1197483E

公开(公告)日：2005-06-30

申请号：PT01122344

申请日：2001-09-19

Applicant: BASF AG

Inventor： MULLER THOMAS ,  JOHANNES GRIMMER ,  ERNST HANSGEORG

IPC: C07D317/46 ,  A61K31/045 ,  A61K31/12 ,  C07C45/00 ,  C07C45/62 ,  C07C49/743 ,  C07C49/753 ,  C07C403/08 ,  C07D317/00 ,  C07D317/12 ,  C07D317/48 ,  C07F7/18

Abstract: A process is provided for the preparation of cyclohexene derivatives of general formula I or II:in which the substituents R and R independently of one another are defined as follows:R isR is OH or a protective group convertible to a hydroxyl group by hydrolysis;R and R are hydrogen or C1-C4-alkyl; andR is hydrogen or C1-C4-acyl,by the reduction of alkyne compounds of general formula III or IV:in which the substituents R and X are as defined above, wherein the reducing agent used is a mixture of zinc and at least one compound B selected from the group consisting of ammonium salts, copper salts and alkali metal and alkaline earth metal salts.

公开(公告)号：CA2542052A1

公开(公告)日：2005-05-12

申请号：CA2542052

申请日：2004-10-15

Applicant: BASF AG

Inventor： HENRICH KLAUS ,  ERNST HANSGEORG

IPC: C07C1/00 ,  C07C1/34 ,  C07C11/21 ,  C07C45/51 ,  C07C45/59 ,  C07C45/60 ,  C07C47/21

Abstract: The invention relates to a process for preparing phytofluene of the formula I, where a) a phosphonium salt of the formula II is condensed with an aldehyde of the formula III in a Wittig reaction to give an acetal of the formula IV b) the condensation product of the formula IV is subjected to an acid-catalyzed acetal hydrolysis to give the aldehyde of the formula V c) and V is condensed in a further Wittig reaction with a phosphonium salt of the formula VI to give phytofluene where the radicals R 1 , R 2 and R 7 , and X - and Y - have the meaning sated in the description.

公开(公告)号：DE10145223A1

公开(公告)日：2003-04-03

申请号：DE10145223

申请日：2001-09-13

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  HENRICH KLAUS ,  DITRICH KLAUS

IPC: A61K31/045 ,  C07B61/00 ,  C07C29/74 ,  C07C35/17 ,  C07C35/18 ,  C07C43/196 ,  C07C47/21 ,  C07C47/225 ,  C07C69/013 ,  C07C69/14 ,  C07C69/16 ,  C07C69/63 ,  C07C69/65 ,  C07C403/08 ,  C07C403/24 ,  C07C29/09 ,  C07C29/78

Abstract: Preparation of meso-zeaxanthin (A) involves separating a racemic mixture of 1-ethynyl-2,2,6-trimethyl-cyclohexane-1,4-diols (I) into the R- and S-antipodes, then converting them into sterically uniform (A) by four further stages including two Wittig reactions. Several classes of intermediate compounds are new. Preparation of meso-zeaxanthin of formula (A) involves: (a) separating a racemic mixture of acetylenic diols of formulae R-(I) and S-(I) into its antipodes; (b) converting R-(I) and S-(I) into the corresponding 15C phosphonium salts of formulae R-(II) and S-(II) respectively; (c) subjecting R-(II) or S-(II) to Wittig reaction with a 10C dial monoacetal of formula (III), to give a 25C acetal of formula R-(IV) or S-(IV); (d) converting R-(IV) or S-(IV) into the 25C aldehyde of formula R-(V) or S-(V) respectively; and (e) subjecting R-(V) and S-(II) or S-(V) and R-(II) to Wittig reaction to give sterically uniform (A). Ar = aryl; X = 1 equivalent of an anion of an (in)organic acid; R1, R2 = 1-8C alkyl, or R1 + R2 = CH2CR3R4CH2 or CHR5CH2, and R3-R5 = H or 1-4C alkyl. Independent claims are also included for: (i) the production of optically pure R-(I) and S-(I), by conversion of a racemic mixture of R-(I) and S-(I) into a diastereomer mixture using an optically active auxiliary reagent (AR), separating the diastereomers and cleaving AR, and (ii) S-(I), protected S-(I) derivatives of formula S-(XI), cyclohexane derivatives of formulae R-(VI) and S-(VI) and acetylene compounds of formula S-(VII) as new compounds. R6 = optically active urethane, carbonate, sulfonate or acyl residue; R7 = H, 1-12C acyl or a hydrolytically cleavable acetal or ether protecting group; R8 = H or C(Me)(OR9)-CH-CH2; R9 = H or Li, and R10 = non-chiral 1-12C acyl or a hydrolytically cleavable acetal or ether protecting group.

公开(公告)号：DE10105799A1

公开(公告)日：2002-08-08

申请号：DE10105799

申请日：2001-02-07

Applicant: BASF AG

Inventor： KLEIN DANIELA ,  ERNST HANSGEORG ,  KOPPENHOEFER JUERGEN

IPC: C07C51/09 ,  C07C67/343 ,  C07C51/353 ,  C07C57/03

Abstract: Cis-6-hexadecenoic acid is prepared by reacting a triphenylphosphonium salt with decanal or other aldehyde in a Wittig reaction, and saponifying the resulting ester. Preparation of cis-6-hexadecenoic acid of formula COOH-(CH2)4-CH=CH-(CH2)8-CH3 involves: (a) reacting either: (i) a triphenylphosphonium salt of formula R1>OOC-(CH2)5-P(R2>)3+>X-> with decanal of formula CH3-(CH2)8-CH=O, or (ii) a triphenylphosphonium salt of formula CH3-(CH2)9-P(R2>)3+>X-> with an aldehyde of formula R1>OOC-(CH2)4-CH=O in a Wittig reaction; and (b) saponifying the resulting ester of formula R1>OOC-(CH2)4-CH=CH-(CH2)8-CH3. R1>1-12C alkyl or aryl; R2>aryl; X->anion equivalent of (in)organic acid.

公开(公告)号：DK169327B1

公开(公告)日：1994-10-10

申请号：DK234687

申请日：1987-05-08

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  LEININGER HARTMUT ,  PAUST JOACHIM

IPC: C07B61/00 ,  B01J25/00 ,  B01J25/02 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C215/10 ,  C07C215/16 ,  C07C215/68 ,  C07H5/04

Abstract: N-(D)-ribitylxylidine (I) is prepared by reacting (D)-ribose (II) with 3,4-dimethylaniline (III) or 3,4-dimethyl-1-nitrobenzene (IV) in aqueous or aqueous/organic solution or in solution in a water-soluble organic solvent under an elevated hydrogen pressure and in the presence of a hydrogenation catalyst and of a boric acid compound, (a) using the boric acid compound in a catalytic amount of from about 6 to 35 mmol, preferably from 6 to 20 mmol, per mol of ribose, (b) carrying out the reaction under a hydrogen pressure of from 1 to 20, preferably from 2 to 9, bar and (c) carrying out the hydrogenation at from 40 DEG to 80 DEG C. over Raney nickel as hydrogenation catalyst.

公开(公告)号：ES2015098B3

公开(公告)日：1990-08-01

申请号：ES88104304

申请日：1988-03-18

Applicant: BASF AG

Inventor： KRIEG WOLFGANG ,  ERNST HANSGEORG ,  BUSCHMANN ERNST ,  FRANCKE WITTKO ,  ENGELS WOLF

IPC: A01N27/00 ,  A01N49/00 ,  C07C1/00 ,  C07C9/22 ,  C07C67/00

公开(公告)号：DK433689D0

公开(公告)日：1989-09-01

申请号：DK433689

申请日：1989-09-01

Applicant: BASF AG

Inventor： PAUST JOACHIM ,  ERNST HANSGEORG

IPC: C07D239/42

Abstract: In an improved process for the preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine of the formula I I by reacting butyramidine II II with alpha -methoxymethyl- beta -methoxyacrylonitrile III III the butyramidine II is reacted with a 0.4-5 molar excess of alpha -methoxymethyl- beta -methoxyacrylonitrile III at from -10 DEG to +20 DEG C.