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公开(公告)号：ZA200107978B
公开(公告)日：2003-03-26
申请号：ZA200107978
申请日：2001-09-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , C12N9/99 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078 , C07K , C07D , A61K , A61P
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号：HU0203167A2
公开(公告)日：2003-02-28
申请号：HU0203167
申请日：2000-03-28
Applicant: BASF AG
Inventor： HAUPT ANDREAS , HILLEN HEINZ , KLING ANDREAS , MACK HELMUT , SCHMIDT MARTIN , SEITZ WERNER , ZECHEL JOHANN-CHRISTIAN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号：CA2411549A1
公开(公告)日：2002-12-05
申请号：CA2411549
申请日：2001-06-06
Applicant: BASF AG
Inventor： SUBKOWSKI THOMAS , HORNBERGER WILFRIED , GRAEF CLAUDIA ISABELLA , SEITZ WERNER , LAUTERBACH ARNULF , LANGE UDO , KLING ANDREAS , GENESTE HERVE
IPC: C07D223/10 , A61K31/55 , A61K31/5513 , A61K45/00 , A61K45/06 , A61P3/10 , A61P5/18 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07D263/48 , C07D277/08 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07K5/023
Abstract: The invention relates to the use of cyclic compounds as ligands of integrin receptors, in particular as ligands of the .alpha.v.szlig.3 integrin recepto r. The invention also relates to the novel compounds, to the use thereof and to pharmaceutical preparations which contain said compounds. Examples of said compounds include benzazepines, benzodiazepines and thieno[3,2-b]azepines, used for treating arteriosclerosis, rheumatoid arthritis, restenosis after vessel damage or stent implantation, angioplasty, acute kidney failure, microangiopathy associated with angiogenesis, diabetic angiopathy, thrombocy te- mediated vascular occlusion, arterial thrombosis, congestive heart-failure, myocardial infarct, apoplexy, cancer, osteoporosis, hypertension, psoriasis or viral, parasitic or bacterial diseases, inflammation, wound healing, hyperparathyroidism, Paget's bone disease, malignant hypercalcemia, or metastatic osteolytic lesions.
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公开(公告)号：BG63697B1
公开(公告)日：2002-09-30
申请号：BG10183597
申请日：1997-08-15
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HOEFFKEN HANS W , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The description relates to compounds of formula in which A, B, D, R' and R have the meanings given in the specification. the compounds am suitable for the treatment of diseases The novel compounds are produced via compounds of the formula H2N-CH2.G-M in which G and M have the meanings given in the specification. 3 claims
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公开(公告)号：CZ20013577A3
公开(公告)日：2002-07-17
申请号：CZ20013577
申请日：2000-03-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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Patent Agency Ranking
公开(公告)号：BG105986A
公开(公告)日：2002-06-28
申请号：BG10598601
申请日：2001-10-05
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065 , A61K38/05
Abstract: The invention relates to prodrugs of pharmaceutically active, five-membered heterocyclic amidines from which in vivo compounds are obtained, these compounds being competitive inhibitors of trypsin-type serin proteases, especially thrombin and kininogenases such as kallikrein, as well as to their preparation and utilization as medicamentous means. The invention also relates to the production of these prodrugs and to their use as medicaments, to pharmaceutical compositions that contain the prodrugs of the active compounds as components, and to the use of the compounds as thrombin inhibitors, anti-coagulants and anti-inflammatory agents. 10 claims
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公开(公告)号：BG105985A
公开(公告)日：2002-06-28
申请号：BG10598501
申请日：2001-10-05
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065 , A61K31/4427
Abstract: The present invention relates to prodrugs of general formula (I) given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds, which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments. 10 claims
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公开(公告)号：SK14232001A3
公开(公告)日：2002-06-04
申请号：SK14232001
申请日：2000-03-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , C12N9/99 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号：DE10027514A1
公开(公告)日：2002-01-03
申请号：DE10027514
申请日：2000-06-06
Applicant: BASF AG
Inventor： GENESTE HERVE , KLING ANDREAS , LANGE UDO , LAUTERBACH ARNULF , SEITZ WERNER , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HORNBERGER WILFRIED
IPC: C07D223/10 , A61K31/55 , A61K31/5513 , A61K45/00 , A61K45/06 , A61P3/10 , A61P5/18 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07D263/48 , C07D277/08 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07K5/023 , C07D405/12
Abstract: The invention relates to the use of cyclic compounds as ligands of integrin receptors, in particular as ligands of the alpha vss3 integrin receptor. The invention also relates to the novel compounds, to the use thereof and to pharmaceutical preparations which contain said compounds.
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公开(公告)号：AU8574801A
公开(公告)日：2001-12-24
申请号：AU8574801
申请日：2001-06-15
Applicant: BASF AG
Inventor： GENESTE HERVE , KLING ANDREAS , LANGE UDO , LAUTERBACH ARNULF , SEITZ WERNER , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HORNBERGER WILFRIED
IPC: A61K45/06 , A61P9/00 , C07D223/16 , C07D403/12 , A61K31/55
Abstract: The invention relates to novel compounds which bind to integrin receptors, their use as ligands of integrin receptors, in particular as ligands of the αv&bgr;3 integrin receptor, and pharmaceutical preparations comprising these compounds.
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